Lack of mutagenic activity of dimethylformamide

Antoine, J.L.; Arany, J.; Léonard, A.; Henrotte, J. G.; Jenar-Dubuisson, G.; Decat, G.

doi:10.1016/0300-483x(83)90082-3

Cited by 21 publications

(9 citation statements)

References 5 publications

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“…Our previous study was unable to demonstrate any association between DMF exposure and SCE frequency alteration in peripheral lymphocytes from DMF-exposed workers (Cheng et al 1999). Evidence from a comprehensive mutagenicity study, including an Ames test, indicates DMF is not a mutagen (Antoine et al 1983). …”

Section: Study Subjects and Epidemiological Datamentioning

confidence: 95%

XRCC1 , CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers

Wong

Wang

Hsieh

et al. 2003

Archives of Toxicology

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Vinyl chloride monomer (VCM) is a known human carcinogen, which may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2), and glutathione S-transferase T1 (GSTT1). A DNA-repair gene, X-ray repair cross-complementing group 1 ( XRCC1, exon 10), may also be implicated in the process of VCM-related carcinogenesis. Thus, VCM-exposed workers with inherited susceptible metabolic and DNA-repair genotypes may experience an increased risk of genotoxiciy. This study was designed to investigate whether metabolic and DNA-repair genotypes affected sister chromatid exchange (SCE) frequency in occupationally VCM-exposed workers from polyvinyl chloride (PVC) manufacturing plants. Study subjects comprised 61 male workers having experienced VCM exposure, and 29 male controls. Questionnaires were administered to obtain detailed histories of cigarette-smoking habits, alcohol consumption behavior, and occupation. The frequency of SCE in peripheral lymphocytes was determined using a standardized method, and genotypes of CYP2E1, ALDH2, GSTT1 and XRCC1 were identified by the polymerase chain reaction (PCR) procedure. Our results demonstrated that smoking, age and VCM exposure and XRCC1 ( P=0.03), CYP2E1 ( P=0.04), and ALDH2 ( P=0.08) were significantly associated with an increased SCE frequency. Further analysis of gene combinations, including CYP2E1, ALDH2 and XRCC1, revealed an increased trend for these genotypes to influence SCE frequencies for the low VCM-exposure group ( P<0.01), but not so for the high VCM-exposure group ( P=0.29) or for controls ( P=0.49). These results suggest that workers with susceptible metabolic and DNA-repair genotypes, may experience an increased risk of DNA damage elicited by VCM exposure.

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Section: Study Subjects and Epidemiological Datamentioning

confidence: 95%

XRCC1 , CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers

Wong

Wang

Hsieh

et al. 2003

Archives of Toxicology

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“…Developmental effects included reduced fetal weight; increases in the litter incidence of total external, skeletal, and visceral malformations and skeletal variations; and increased number and percentage of dead implants (BASF 1974a,b,c;Kimmerle and Machemer 1975;BASF 1989;Hellwig et al 1991;Lewis et al 1992). Genotoxicity testing of DMF has generally been negative (Antoine et al 1983;NTP 1992). One study found no evidence of carcinogenicity when mice and rats inhaled DMF up to 400 ppm for 2 years (E.I.…”

Section: Discussionmentioning

confidence: 99%

“…DMF failed to induce chromosomal aberrations or sister chromatid exchanges in vitro in lymphocytes from a healthy male donor (Antoine et al 1983).…”

Section: Genotoxicitymentioning

confidence: 92%

Acute Exposure Guideline Levels for Selected Airborne Chemicals

2013

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The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the National Research Council.

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“…In vitro chromosomal aberration studies with human lymphocytes produced both negative (Antoine et al 1983) and positive (Koudela and Spazier 1979) results (Table 9).…”

Section: Mammalian Cell Culturesmentioning

confidence: 99%

“…The dimethylformamide exposure was also significantly concentrations in groups 2 and 3 were close as were those in group 2 and those for two persons from group 1. In the discussion, the authors drew attention to the contradiction between the increased incidences of SCE and chromosomal aberrations in persons exposed to dimethylformamide (Berger et al 1985, Koudela andSpazier 1979) and the negative results of experimental studies (Antoine et al 1983, Mortelmans et al 1986.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Dimethylformamide [MAK Value Documentation, 1997]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 8 (1997) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute and subacute toxicity Subchronic and chronic toxicity Reproductive and Developmental Toxicity Genotoxicity Microbial test systems Mammalian cell cultures In vivo Carcinogenicity Other Effects Manifesto (MAK value, classification)

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Lack of mutagenic activity of dimethylformamide

Cited by 21 publications

References 5 publications

XRCC1 , CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers

XRCC1 , CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Dimethylformamide [MAK Value Documentation, 1997]

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