2019
DOI: 10.1007/s00429-019-01860-6
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Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system

Abstract: The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The Xlinked gene MECP2, associated to several neurodevelopmental disorders such as Rett Syndrome, encodes the protein methyl-CpG-binding protein 2 (MeCP2), a regulatory protein that has been implicated in neuronal maturation and refinement of olfactory circuits. Here we explored doublecortin immunoreactivity in the brain of young-adult female Mecp2-heterozygous and male Mecp2-null mice and their wild-type littermates. T… Show more

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Cited by 10 publications
(15 citation statements)
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“…Immunoreactivity to DCX, a marker of immature neurons, shows that lack of Mecp2 leads to an increase in the density of immature neurons at the Pir and the OT, similar to that we previously reported at early adulthood, 8 weeks of age ( Martínez-Rodríguez et al, 2019 ). Further, MS uncovers an increase in the density of immature neurons at other regions, including the hippocampus, of adolescent Mecp2 -null mice.…”
Section: Discussionsupporting
confidence: 89%
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“…Immunoreactivity to DCX, a marker of immature neurons, shows that lack of Mecp2 leads to an increase in the density of immature neurons at the Pir and the OT, similar to that we previously reported at early adulthood, 8 weeks of age ( Martínez-Rodríguez et al, 2019 ). Further, MS uncovers an increase in the density of immature neurons at other regions, including the hippocampus, of adolescent Mecp2 -null mice.…”
Section: Discussionsupporting
confidence: 89%
“…Maternal separation exacerbates the increase in the density of doublecortin -ir neurons caused by lack of Mecp2, and both maternal separation and lack of Mecp2 decrease reelin-ir in a region dependent manner Immunoreactivity to DCX, a marker of immature neurons, shows that lack of Mecp2 leads to an increase in the density of immature neurons at the Pir and the OT, similar to that we previously reported at early adulthood, 8 weeks of age (Martínez-Rodríguez et al, 2019). Further, MS uncovers an 10.3389/fnbeh.2022.974692 increase in the density of immature neurons at other regions, including the hippocampus, of adolescent Mecp2-null mice.…”
Section: Neuronal Activation Pattern In Anxiety/stress-related Brain ...supporting
confidence: 87%
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“…In this strain, hemizygous males (Mecp2-null) are infertile, so the breeding pairs are established with Mecp2-heterozygous (Mecp2-het) females paired to WT males. This impedes the production of Mecp2-null females in this strain, and hence, in this study, we compare males and females separately, as we did in a previous study (Martínez-Rodríguez et al 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Ultimately, the complex of mental and communicative disorders resembles Kanner's syndrome with signs of oligophrenia [32,33]. Etiologically, the disease develops due to a mutation in the MECP2 gene located on the X chromosome [34,35].…”
mentioning
confidence: 99%