Lack of Insight in Psychiatric Illness: A Critical Appraisal

Ms, Reddy

doi:10.4103/0253-7176.183080

Cited by 12 publications

(23 citation statements)

References 13 publications

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“…The ethical dilemma in emergency psychiatry continues to remain debatable [8][9][10][11][12][13][14][15][16][17]. The general principle of autonomy, which permits patients to refuse or accept treatment, is frequently called into question when patients present with presentations that are clouded by impaired decision-making capacity and presenting with common symptoms like acute psychomotor agitation, suicidal ideations, homicidal ideations, threats of self-harm or violence to caretakers, and self-neglect [17][18].…”

Section: Emergency Approaches To Medication Administration In Patient...mentioning

confidence: 99%

Approaches to Medication Administration in Patients With Lack of Insight

Okobi¹,

Agazie²,

Ayisire³

et al. 2022

Cureus

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Lack of insight typically complicates psychiatric presentations, necessitating careful thought and planning to choose the best course of treatment. Exploring methods of medication administration techniques in the context of a lack of insight is crucial to achieving the ultimate goal of overcoming the insight barrier as rapidly as possible, which will result in therapeutic benefit. This study's objective was to systematically review the evidence on medication administration techniques in a backdrop of lack of insight and how that evidence was curated in the scientific literature. This study used the literature search strategy, which entails retrieving and analyzing the existing scientific literature pertinent to medication administration techniques for individuals with no insight between 2010 and 2022. Accessing online databases, such as PubMed, Google Scholar, and Medline was utilized in this study's literature search strategy. In our findings, in the primary evidence search, no randomized control trial (RCT) comparing the various models of medication administration with a lack of insight was found. No study provided data on the superiority of utility, quality of life, or efficacy outcome. Some 17 scientific papers were identified that cited various trials about lack of insight and medication use and met the inclusion criteria. We concluded that it could be challenging to administer medication to patients who lack insight.Nonetheless, progress has been made to mitigate this obstacle. Common moral values, common sense, medicolegal support, person-centered integrated care, and cutting-edge medication techniques may play a role. However, these models of medication administration are still evolving, along with the ethical concerns accompanying them. Hopefully, the available models discussed in this analysis will serve as a foundation for future developments. Nonetheless, much remains to be done. We encourage contemporary research to investigate safer and more dynamic methods that can alleviate this condition.

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Section: Emergency Approaches To Medication Administration In Patient...mentioning

confidence: 99%

Approaches to Medication Administration in Patients With Lack of Insight

Okobi¹,

Agazie²,

Ayisire³

et al. 2022

Cureus

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“…In this disorder, patients think they can completely do everything. Proper functioning of the brain based on a complex set of brain calculations and any defects or failure or dysregulation of these mechanisms caused psychiatric illnesses 143 . It involves a pathological mechanism in it, and this condition interferes with motivational, cognitive, and emotional brain systems lead to dysregulation of the brain systems underlying insight regulation.…”

Section: Lack Of Awareness Into Psychiatric Illness: a Critical Reviementioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynurenine pathway, and excessively produced neurotoxic substances. These uncontrolled happenings in the etiology of psychiatric disorders initiate further changes in neurotransmitter metabolism, pathologic microglial, cell activation, and impaired neuroplasticity. Inflammatory cytokines, the outcome of dysfunctional mitochondria, dysregulation of the immune system, and under stress functions of the brain are leading biochemical factors for depression and anxiety. Nanoscale drug delivery platforms, inexpensive diagnostics using nanomaterials, nano-scale imaging technologies, and ligand-conjugated nanocrystals used for elucidating the molecular mechanisms and foremost cellular communications liable for such disorders are highly capable features to study for efficient diagnosis and therapy of the mental illness. These theranostic tools made up of multifunctional nanomaterials have the potential for effective and accurate diagnosis, imaging of psychiatric disorders, and are at the forefront of leading technologies in nanotheranostics openings field as they can collectively and efficiently target the stimulated territories of the cerebellum (cells and tissues) through molecular-scale interactions with higher bioavailability, and bio-accessibility. Specifically, the nanoplatforms based neurological changes are playing a significant role in the diagnosis of psychiatric disorders and portraying the routes of functional restoration of mental disorders by newer imaging tools at nano-level in all directions. Because of these nanotherapeutic platforms, the molecules of nanomedicine can penetrate the Blood-Brain Barrier with an increased half-life of drug molecules. The discoveries in nanotheranostics and nanotherapeutics inbuilt unique multi-functionalities are providing the best multiplicities of novel nanotherapeutic potentialities with no toxicity concerns at the level of nano range.

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“…O motivo principal destas mudanças consiste no crescente número de evidências que apontam para uma estrutura heterogênea do insight De Assis Da Silva, Mograbi, Bifano, Santana, & Cheniaux, 2016), que passou a ser tratado como uma variável multidimensional ao invés de binária (De Assis . No entanto, o curso da evolução do conceito de insight não se restringe à mudança do entendimento entre sua presença/ausência ou dimensões (Reddy, 2016). Em uma fase intermediária, concebeu-se que esta função possuiria uma dimensão que poderia variar da completa negação (grau 1) até um verdadeiro insight emocional (grau 6).…”

Section: Insightunclassified

“…Em uma fase intermediária, concebeu-se que esta função possuiria uma dimensão que poderia variar da completa negação (grau 1) até um verdadeiro insight emocional (grau 6). Este modelo incorporava o entendimento da sua causação devido à fatores internos ou externos (Reddy, 2016).…”

Section: Insightunclassified

“…Do ponto de vista da evolução do debate, independente da crítica estabelecida pela visão mais antropológica do tema, a ideia de uma multidimensionalidade desta função tem sido a mais empregada Mograbi & Morris, 2013a;Reddy, 2016;De Assis Da Silva et al, 2016). A raiz desta mudança de tratamento deriva-se de dois fatores: (1) da abordagem do insight como um conceito relacional ou "intencional", sendo sempre possível compreendê-lo em relação a algo e, portanto, este 'algo' é o objeto do insight .…”

Section: Insightunclassified

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Insight Implícito No Transtorno Bipolar

NASCIMENTO¹

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Ao meu orientador Prof. Daniel Mograbi, gostaria de agradecer profundamente pelo voto de confiança e por todo o suporte ao longo de todo este projeto. Sua orientação e conselhos foram indispensáveis para que esse trabalho tenha sido concluído com êxito. Ao Professor J. Landeira-Fernandez, o meu muito obrigado pelas contribuições teóricas fornecidas ao longo do projeto. Ao Prof. Elie Cheniaux, os meus agradecimentos pelo suporte oferecido no atendimento aos pacientes bipolares e por compartilhar o conhecimento da área de forma tão precisa. Ao Prof. Felipe Sudo, pela gentil colaboração no projeto. Ao Dr. Rafael Assis, pelo apoio oferecido ao longo desta pesquisa assim como pelos conhecimentos compartilhados acerca da população estudada. Ao CNPq e à PUC-Rio, pelo auxílios concedidos, sem os quais este trabalho não poderia ter sido realizado. Aos funcionários PUC-Rio, os meus sinceros agradecimentos, em especial aos funcionários do Departamento de Psicologia. Sem o auxílio deles, essa caminhada seria muito mais difícil. Aos amigos do Mograbilab, o meu muito obrigado por compartilharem um espírito científico de pesquisa inspirador e excitante. Em especial gostaria de agradecer por toda a ajuda da Drª Elodie Bertrand que teve uma contribuição inestimável para que este projeto fosse concluído de forma satisfatória e aos integrantes da equipe de pesquisa, Pâmela Indeli, Ticiana Sampaio, Fernanda Alves e Camila Garbin. À Drª Elizabeth Vallier, o meu agradecimento por ter me ajudado com o suporte médico necessário ao longo desta jornada. Palavras-chave insight; insight implícito; autoconsciência; transtorno bipolar; mania; depressão; teste de associação implícita.

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Lack of Insight in Psychiatric Illness: A Critical Appraisal

Cited by 12 publications

References 13 publications

Approaches to Medication Administration in Patients With Lack of Insight

Approaches to Medication Administration in Patients With Lack of Insight

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Insight Implícito No Transtorno Bipolar

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