Lack of influence of thyroid antibodies on thyroid function in the newborn infant and on a mass screening program for congenital hypothyroidism

Dussault, J H; Letarte, Jacques; Guyda, H.; Laberge, Claude

doi:10.1016/s0022-3476(80)80677-9

Cited by 73 publications

(27 citation statements)

References 14 publications

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“…No goitre was seen, confirming previous suggestions that the thyroid antibodies per se do not induce goitre and -in atrophic thyroiditis -might inhibit thyroid growth [10][11][12],…”

Section: Discussionsupporting

confidence: 86%

Atrophic, Autoimmune Thyroiditis in Infancy

Østergaard

Jacobsen²

1989

Horm Res

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Autoimmune thyroiditis in infancy is a very rare condition. Only 1 case has been reported previously. In the present patient an aquired primary hypothyroidism with high titers of thyroid microsomal antibodies was diagnosed at the age of 7 months. The patient died at 9 months of age in a sepsis-like condition. Autopsy revealed an atrophic thyroiditis. The more severe and complex clinical picture of autoimmune thyroiditis in infancy compared to that later in childhood is discussed.

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“…No goitre was seen, confirming previous suggestions that the thyroid antibodies per se do not induce goitre and -in atrophic thyroiditis -might inhibit thyroid growth [10][11][12],…”

Section: Discussionsupporting

confidence: 86%

Atrophic, Autoimmune Thyroiditis in Infancy

Østergaard

Jacobsen²

1989

Horm Res

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“…The presence of thyroid peroxidase antibodies (TPOAb) is frequent associated to thyroiditis in women of childbearing age; TPOAb have been found in 10% of women during or shortly after pregnancy [11]. Dussault et al reported that there is no correlation between the presence of maternal antimicrosomal antibodies and congenital hypothyroidism[12]; a further study conducted in Quebec in 1999 demonstrated an increased prevalence of transient congenital hypothyroidism associated with maternal autoimmune thyroid disease, particularly antimicrosomal autoantibodies were found in 77% of mothers of infants with transient congenital hypothyroidism[13]. Furthermore, the presence of maternal TPOAb with normal maternal thyroid function has been described in association with impaired neuropsychological development during early childhood [14].…”

Section: Introductionmentioning

confidence: 99%

Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life

et al. 2010

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Backgroundevaluation of thyroid function in neonates born from mothers affected by autoimmune thyroiditis in order to define if a precise follow-up is necessary for these children. The influence of maternal thyroid peroxidase antibody (TPOAb) and L-thyroxine therapy during pregnancy on neonatal thyroid function was also investigated.Methods129 neonates were tested for thyroid function by measurement of free thyroxine (FT4) and thyroid stimulating hormone (TSH) in 3th day, 15th day and at one month of life. TPOAb were measured in all patients; periodical control of thyroid function were performed until 6 months of life if Ab were positive. Data concerning etiology of maternal hypothyroidism and maternal replacement therapy with L-thyroxine during pregnancy were retrospectively collected.Results28% neonates showed at least a mild increase of TSH value at the different determinations. In the majority of them, a spontaneous completely normalisation of TSH value was observed within the first month life. L-thyroxine replacement therapy was started in 3 neonates. TPOAb titer and maternal L-thyroxine replacement therapy were not related to alteration of thyroid hormone function in our study population.Conclusionstransient mild elevation of serum TSH above the normal reference value for age is frequently observed in the first month of life in infants born from mothers affected by autoimmune thyroiditis. Persistent hyperthyrotropinemia requiring replacement therapy is observed in 2.2% of these neonates. According to our experience, follow-up is recommended in these newborns; the most accurate and not invasive way to carefully monitor these infants after neonatal screening for CH seems to be serum-testing TSH between 2ndand 4th week of life.

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“…miana przeciwciał ATPO i ATG nie korelowały ze stężeniem TSH, występowały u 2/3 dzieci wymagających leczenia LT4. Jest to kolejne potwierdzenie, że zarówno przeciwciała ATPO, jak i ATG nie mają wpływu na funkcję tarczycy płodu i noworodka [21][22][23]. Z drugiej strony Weber i wsp.…”

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Hashimoto thyroiditis in mother and thyroid function in offspring – a prospective study

Zubkiewicz‐Kucharska¹,

Chrzanowska²,

Noczyńska³

2015

Pediatr. Endocrinol.

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Autoimmune thyroid disease (AITD) is diagnosed in 5-20% of pregnant women. Autoimmune thyroid disease in mother may be a cause of thyroid dysfunction in child. Hypothyroidism induced by thyrotropin receptor blocking antibodies (TRBAb) is present in 1-2% of children with congenital hypothyroidism. The aim of this paper was to evaluate thyroid function and presence of antithyroid antibodies in children of mothers with Hashimoto thyroiditis in the first year of life. Material and methods. 367 children were included into the study (185 boys, 182 girls, two twin pregnancies) of mothers with Hashimoto thyroiditis. The first visit in endocrinology out-patient clinic was done in 1 st -2 nd month of life, the follow-up visit at 6 th -9 th month of life. Anthropometrics were taken as well as blood samples for TSH, fT3, fT4, ATPO and ATG. Mothers had all proper thyroid function during the whole pregnancy. Results. 339 children (92,4%) were born on term, 281 (76,6%) with normal vaginal delivery, in good condition and with proper body mass. In three patients trisomy 21 was diagnosed. The neurological development of all children was not concerning. Thyroid function was proper (mean TSH 5,41±0,90 μIU/ml, fT3 8,00±1,24 pg/ml, fT4 16,89±2,09 pmol/l). None of the observed child had elevated titer of antithyroid antibodies. Conclusions. 1. Malfunction of the thyroid gland in children of mothers with Hashimoto thyroiditis is rare, therefore no further diagnostic procedures except screening test is required. 2. In preterm babies as well as in children presenting chaSłowa kluczowe choroba Hashimoto, autoimmunizacyjna choroba tarczycy, wrodzona niedoczynność tarczycy StreszczenieAutoimmunizacyjną chorobę tarczycy (AITD, autoimmune thyroid disease) rozpoznaje się u 5-20% ciężarnych. AITD u matki może być przyczyną dysfunkcji tarczycy u dziecka. Niedoczynność tarczycy wywołana przez przeciwciała blokujące receptor TSH (TRBAb, thyrotropin receptor blocking antibodies) występuje u 1-2% dzieci z wrodzoną niedoczynnością tarczycy. Celem pracy była ocena funkcji tarczycy oraz obecności przeciwciał przeciwtarczycowych u dzieci matek chorujących na przewlekłe limfocytarne zapalenie tarczycy typu Hashimoto w pierwszym roku ich życia. Materiał i metody. Badaniem objęto 367 dzieci (185 chłopców oraz 182 dziewczynki, dwie ciąże bliźniacze) urodzonych przez matki chorują-ce na chorobę Hashimoto. Odbyły się dwie wizyty w poradni endokrynologicznej: w 1-2 miesiącu życia i w 6-9 miesiącu życia. Wykonano pomiary antropometryczne oraz pobrano krew w celu oceny stężenia TSH, fT3, fT4, ATPO, ATG. Funkcja tarczycy u matek była wyrównana w czasie całej ciąży. Wyniki. 339 dzieci (92,4%) było urodzonych o czasie, 281 (76,6%) siłami natury, wszystkie w stanie dobrym i z prawidło-wą masą ciała. U trojga rozpoznano trisomię 21. Rozwój psychomotoryczny w czasie obserwacji nie budził niepokoju. Funkcja tarczycy u wszystkich dzieci była prawidłowa (średnie TSH 5,41±0,90 μIU/ml, fT3 8,00±1,24 pg/ml, fT4 16,89±2,09 pmol/l). U żadne-go dziecka nie stwierdzono ...

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Lack of influence of thyroid antibodies on thyroid function in the newborn infant and on a mass screening program for congenital hypothyroidism

Cited by 73 publications

References 14 publications

Atrophic, Autoimmune Thyroiditis in Infancy

Atrophic, Autoimmune Thyroiditis in Infancy

Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life

Hashimoto thyroiditis in mother and thyroid function in offspring – a prospective study

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