Lack of Increased P15<sup>INK4B</sup>Protein Expression in Basal Cell Carcinomas

Moad, Ahmed Ismail Hassan; Tan, Mei Lan; Kaur, Gurjeet; Mabruk, Mohamed

doi:10.7314/apjcp.2012.13.12.6239

Cited by 2 publications

(2 citation statements)

References 37 publications

(37 reference statements)

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“…BCC is well known for its slow growing feature within the epidermis of skin (Moad et al, 2012). BCC is locally invasive and rarely metastatic with a high rate of recurrence.…”

Section: Introductionmentioning

confidence: 99%

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

Rajabpour

Raoofian²,

Youssefian³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC). However, BMI1, TWIST1 and SNAI2 expression levels in basal cell carcinomas (BCCs) have not been elucidated. We hypothesized BCC could be a good model system to decipher mechanisms which inhibit processes that drive tumor metastasis. The aim of this study was to examine the mRNA expression level of BMI1, TWIST1, and SNAI2 in BCCs. Materials and Methods: Thirty-five fresh non-metastatic BCC tissue samples and seven fresh normal skin tissue samples were evaluated by real-time RT-PCR. Results: BMI1 and TWIST1 demonstrated marked down-regulation (p<0.00l, p=0.00l respectively), but SNAI2 showed no significant change (p=0.12). Conclusions: Previous literature has clearly demonstrated a positive association between BMI1 and TWIST1 expression and metastatic BCC, aggressive SCC and melanoma. Here, we demonstrated a negative association between BMI1 and TWIST1 mRNA expression level and BCC.

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“…BCC is well known for its slow growing feature within the epidermis of skin (Moad et al, 2012). BCC is locally invasive and rarely metastatic with a high rate of recurrence.…”

Section: Introductionmentioning

confidence: 99%

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

Rajabpour

Raoofian²,

Youssefian³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Increasingly, factors are found implicated in cancers concerning their aberrant expression or therapeutic intervention (Moad et al, 2012;Zheng, 2013). However they were mostly inspceted in isolation while new insights on complicated gene regulated network may light on novel strategies for the diagnosis, therapy and prognosis (Xie, 2013).…”

Section: Introductionmentioning

confidence: 99%

Systematical Analysis of Cutaneous Squamous Cell Carcinoma Network of microRNAs, Transcription Factors, and Target and Host Genes

Wang

Xu²,

Wang³

2015

Asian Pacific Journal of Cancer Prevention

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Background: MicroRNAs (miRNAs) are small non-coding RNA molecules found in multicellular eukaryotes which are implicated in development of cancer, including cutaneous squamous cell carcinoma (cSCC). Expression is controlled by transcription factors (TFs) that bind to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to messenger RNA. Interactions result in biological signal control networks. Materials and Methods: Molecular components involved in cSCC were here assembled at abnormally expressed, related and global levels. Networks at these three levels were constructed with corresponding biological factors in term of interactions between miRNAs and target genes, TFs and miRNAs, and host genes and miRNAs. Up/down regulation or mutation of the factors were considered in the context of the regulation and significant patterns were extracted. Results: Participants of the networks were evaluated based on their expression and regulation of other factors. Sub-networks with two core TFs, TP53 and EIF2C2, as the centers are identified. These share self-adapt feedback regulation in which a mutual restraint exists. Up or down regulation of certain genes and miRNAs are discussed. Some, for example the expression of MMP13, were in line with expectation while others, including FGFR3, need further investigation of their unexpected behavior. Conclusions: The present research suggests that dozens of components, miRNAs, TFs, target genes and host genes included, unite as networks through their regulation to function systematically in human cSCC. Networks built under the currently available sources provide critical signal controlling pathways and frequent patterns. Inappropriate controlling signal flow from abnormal expression of key TFs may push the system into an incontrollable situation and therefore contributes to cSCC development.

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Lack of Increased P15^INK4BProtein Expression in Basal Cell Carcinomas

Cited by 2 publications

References 37 publications

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

Systematical Analysis of Cutaneous Squamous Cell Carcinoma Network of microRNAs, Transcription Factors, and Target and Host Genes

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Lack of Increased P15INK4BProtein Expression in Basal Cell Carcinomas

Cited by 2 publications

References 37 publications

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

Systematical Analysis of Cutaneous Squamous Cell Carcinoma Network of microRNAs, Transcription Factors, and Target and Host Genes

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Lack of Increased P15^INK4BProtein Expression in Basal Cell Carcinomas