Lack of Increased FDG Uptake in the Lacrimal and Salivary Glands in Patients With Sarcoidosis and Potential Underlying Mechanism

Shim, Hunbo; Joo, Junghyun; Choi, Hyung Jin; Hyun, Hyewon; Gerbaudo, Victor H.; Kim, Chun Ki

doi:10.1097/rlu.0000000000001127

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…FDG PET CT’s main advantage is that it is a single whole-body examination that can detect various extrapulmonary sites of sarcoidosis [ 66 ]. In FDG PET CT and in Gallium-67 scintigraphy lambda sign and panda signs are used as characteristic signs [ 67 , 68 ] for diagnosis of sarcoidosis. Moreover, other sites of FDG intake can also be helpful for diagnosis by indicating locations for accessible biopsies [ 66 , 69 ] (Fig.…”

Section: Diagnostic Modalitiesmentioning

confidence: 99%

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Bazewicz,

Heissigerova,

Pavesio

et al. 2023

J Ophthal Inflamm Infect

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Sarcoidosis-associated uveitis, is the predominant ocular sarcoidosis presentation, which affects both adults and children. For adults, international ocular sarcoidosis criteria (IWOS) and sarcoidosis-associated uveitis criteria (SUN) are defined. However, for children they are not yet established internationally. Due to the specificity of pediatric manifestations of sarcoidosis, this task is even more challenging. In children, sarcoidosis is subdivided into Blau syndrome and early-onset sarcoidosis (BS/EOS) affecting younger children (< 5 years) and the one affecting older children with clinical presentation resembling adults. Differential diagnosis, clinical work-up as well as diagnostic criteria should be adapted to each age group. In this article, we review the clinical manifestation of sarcoidosis-associated uveitis in adults and children and the sensitivity and specificity of various ocular sarcoidosis diagnostic modalities, including chest X-ray and CT, FDG PET-CT, gallium-67 scintigraphy, bronchoalveolar lavage fluid, genetic testing for NOD2 mutations and serum biomarkers, such as ACE, lysozyme and IL2R.

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Section: Diagnostic Modalitiesmentioning

confidence: 99%

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Bazewicz,

Heissigerova,

Pavesio

et al. 2023

J Ophthal Inflamm Infect

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“…Furthermore, 67 Ga single-photon emission tomography (SPECT) substantially increases confidence in the diagnosis of head and neck tumours when computed tomography (CT) and/or magnetic resonance imaging (MRI) do not permit differentiation between benign and malignant disease [6]. With the exception of SCC, some authors have reported that 67 Ga scintigraphy is useful in the differentiation of malignant lymphoma [7], sarcoidosis [8][9][10], and other inflammatory diseases [11,12].…”

Section: Introductionmentioning

confidence: 99%

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

Oohashi¹,

Toshima²,

Hayama³

et al. 2020

Pol J Radiol

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The aim of this study was to investigate the gallium-67 ( 67 Ga) single-photon emission-computed tomography (SPECT-CT) for the evaluation of head and neck, especially maximum standardised uptake value (SUV max ) in lesions, and in the parotid and submandibular glands. Material and methods:Fourteen patients with head and neck lesions who underwent SPECT-CT at 72 hours after injection of 67 Ga were included in this study. The 67 Ga SPECT-CT parameters SUV max were compared between the parotid glands and submandibular glands. Statistical analyses for the SUV max were performed by Mann-Whitney U test. A p value lower than 0.05 was considered as statistically significant.Results: Of all 14 patients, 67 Ga SPECT-CT was positive for two cases (one malignant lymphoma and one osteomyelitis). The SUV max for malignant lymphoma and osteomyelitis were 11.21 and 10.95, respectively. Furthermore, SUV max for parotid glands and submandibular glands of all patients were 4.86 ± 1.89 and 4.64 ± 1.64, respectively (p = 0.694). Conclusions:This study investigated the 67 Ga SPECT-CT for the evaluation of head and neck, especially SUV max of lesions, and the parotid and submandibular glands. 67 Ga SPECT-CT may be an effective technique for the evaluation of maxillofacial lesions.

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“…Apart from SCC, some authors have reported that 67 Ga scintigraphy is useful in the differentiation of malignant lymphoma [8], sarcoidosis [9-11], and other inflammatory diseases [12,13]. However, to the best of our knowledge, 67 Ga scintigraphy with multimodal imaging, such as CT and MRI, for the comparison of SCC and inflammatory diseases of the oral and maxillofacial region has not been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Comparison between squamous cell carcinoma and inflammatory diseases of the oral and maxillofacial region using gallium-67 scintigraphy with computed tomography and magnetic resonance imaging

Ogura¹,

Oda²,

Sue³

et al. 2018

Pol J Radiol

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PurposeThis study aimed to compare squamous cell carcinoma (SCC) with inflammatory diseases of the oral and maxillofacial region using gallium 67 (67Ga) scintigraphy with computed tomography (CT) and magnetic resonance imaging (MRI).Material and methodsSeventy patients with SCC and 15 patients with inflammatory diseases of the oral and maxillofacial region underwent 67Ga scintigraphy with CT and MRI. A comparison between imaging features of 67Ga scintigraphy, CT, and MRI and lesions was performed with the Pearson’s chi-squared test.Results67Ga scintigraphy was positive for 25 of 39 patients with SCC positive on CT and/or MRI (64.1%) and for 13 of 15 patients with inflammatory diseases positive on CT and/or MRI (86.7%). The detection of inflammatory diseases with 67Ga scintigraphy was higher than that of SCC (p = 0.104).ConclusionsThis study compared SCC with inflammatory diseases of the oral and maxillofacial region using 67Ga scintigraphy with CT and MRI. 67Ga scintigraphy is an effective technique for detection of inflammatory diseases of the oral and maxillofacial region.

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Lack of Increased FDG Uptake in the Lacrimal and Salivary Glands in Patients With Sarcoidosis and Potential Underlying Mechanism

Cited by 7 publications

References 30 publications

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis

Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands

Comparison between squamous cell carcinoma and inflammatory diseases of the oral and maxillofacial region using gallium-67 scintigraphy with computed tomography and magnetic resonance imaging

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