Lack of Impact of Intravenous Lidocaine on Analgesia, Functional Recovery, and Nociceptive Pain Threshold after Total Hip Arthroplasty

Abstract

Low dose perioperative intravenous lidocaine after total hip arthroplasty offers no beneficial effect on postoperative analgesia and does not modify pressure and tactile pain thresholds.

Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials

“…24 Seven studies originated in the USA, [25][26][27][28][29][30][31] one in Belgium, 32 two in Taiwan, 14,33 three in Germany, 23,34,35 one in New Zealand, 36 three in Sweden, [37][38][39] two in China, 40,41 one in France, 42 three in Canada, [43][44][45] one in Mexico, 24 two in Saudi Arabia, 46,47 one in Israel, 48 one in the Republic of Korea 49 and one in Finland. 50 Studies were conducted in patients undergoing abdominal, cardiac, thoracic, orthopedic, or urologic surgery ( Table 1).…”

“…50 Studies were conducted in patients undergoing abdominal, cardiac, thoracic, orthopedic, or urologic surgery ( Table 1). Source of sponsorship was not mentioned in 11 studies, [23][24][25][26][27]29,42,[45][46][47][48] while other studies received grants from foundations, national councils, or universities. No study reported industry sponsorship.…”

“…51 Twenty-six (90%) studies were placebo-controlled blinded studies. 14,[23][24][25][26][27][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][45][46][47][48][49] Primary outcomes…”

“…Laparoscopic colectomy 57 ± 17 Lidocaine infusion for postoperative analgesia 27 scores, 14,24,26,[31][32][33]35,38,40,42,45,47,48 while five studies presented median pain score. 23,25,34,43,44 The data from the studies reporting medians could not be included in the pooled analyses.…”

“…In the four studies presenting median opioid doses, two studies observed results consistent with these findings 32,40 while two studies observed contradicting results. 25,42 Secondary outcomes…”