Lack of heritability in ovarian germ cell malignancies

Shulman, L.P.; Muram, David; Marina, Neyssa; Jones, Claudette E.; Portera, J.Chris; Wachtel, Stephen S.; Simpson, Joe Leigh; Elias, Sherman

doi:10.1016/s0002-9378(94)70356-6

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…The rarity of these cancers, and the close relationships between affected individuals in these families, suggests that a gene conferring susceptibility to germ cell cancers may be present in at least some of these families. Shulman et al [1994] did not observe any germ cell cancers in mothers, sisters, aunts, or grandmothers of 78 women who had been diagnosed with germ cell malignancies. The authors did not investigate the occurrence of testicular cancers in male relatives of their patients.…”

Section: Discussionmentioning

confidence: 65%

“…1). This family was described briefly by Schink in a discussion following an article by Shulman et al [1994], and they are now presented here after the acquisition and review of pertinent medical records. The proposita, herself diagnosed with an endodermal sinus tumor, was cared for at the University of Wisconsin's Gynecologic Oncology Clinic, and presented for genetics counseling because she had a family history of a maternal aunt and a maternal cousin with germ cell cancers, as well as a mother with early onset breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Familial ovarian germ cell cancer: Report and review

et al. 1999

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Ovarian germ cell cancers are rare malignancies accounting for less than 5% of all ovarian cancers. We present a family in which three closely related women were diagnosed with ovarian germ cell malignancies. This family's cancer history prompted a family history investigation of women treated for ovarian germ cell malignancies in the Gynecologic-Oncology Clinic at the University of Wisconsin. One of the eight patients whose family histories were reviewed had an uncle who had been diagnosed with testicular germ cell cancer. A review found six other previously reported families in which more than one relative had been diagnosed with a malignant ovarian germ cell tumor. Additionally, several cases of families with both males and females diagnosed with germ cell cancers have been documented. The low incidence of ovarian germ cell cancers suggests that multiple occurrences in the same family may not be due to chance. Rather, it is possible that a gene conferring susceptibility to ovarian germ cell cancers, and possibly to germ cell tumors in males as well, is present in at least some of these families.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Familial ovarian germ cell cancer: Report and review

et al. 1999

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“…Dysgerminoma is the only histological type with a high incidence of bilaterality (10–17% [72, 73]). There is a high incidence of malignant GCT developing in a patient with dysgenetic gonads and a Y chromosome [74, 75, 76, 77]and other chromosomal abnormalities have also been described [78]but no hereditary ovarian GCT have been identified [79]. …”

Section: Germ Cell Tumoursmentioning

confidence: 99%

Management of Non-Epithelial Ovarian Tumours

Bridgewater

Rustin²

1999

Oncology

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Ovarian tumours of non-epithelial origin are less common than those of epithelial origin but must be distinguished from these as their natural history and management differ. As these tumours are rare, histological review by an expert in the field is essential. There have been no randomised trials to outline the management of these tumours and therefore this paper represents a review of descriptive data. Non-epithelial ovarian tumours, which represent approximately 50% of all ovarian tumours and approximately 25% of malignant ovarian tumours, are outlined. Lymphomas and metastatic tumours should be treated the same as when found in other sites and will not be discussed further.

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“…The evidence for a heritable component of ovarian GCT (OGCT) is less conclusive. A study of 74 cases of ovarian GCT found none with a family history (Shulman et al , 1994) while other reports have described families with cases of both ovarian GCT and either TGCT or extragonadal GCT (Giambartolomei et al , 2009). Population-based studies of familial aggregation do not exist due to the rarity of the disease.…”

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confidence: 96%