Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients

Saeki, Ayuko; Tamura, Shinji; Ito, Nobuyuki; Kiso, Shinichi; Matsuda, Yasuo; Yabuuchi, Iwao; Kawata, Sumio; Matsuzawa, Yūji

doi:10.1002/(sici)1097-0142(20000301)88:5<1025::aid-cncr11>3.3.co;2-l

Cited by 5 publications

(8 citation statements)

References 15 publications

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“…However, these results might be biased by the use of different marker panels with underrepresentation of mononucleotide repeats that offer the best specificity for MMR deficiency-associated MSI in most series. So far, only few studies with conflicting results tried to assess cMSI in HCC to determine a causative role for MSI in HCC formation [13,[32][33][34]. The growing evidence for an overlap of MSI and CIN pathways in CRC [35] also supports the further analysis of the MSI pathway in hepatocarcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

Casper

Weber

Kloor

et al. 2013

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

Casper

Weber

Kloor

et al. 2013

Scandinavian Journal of Gastroenterology

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“…The most recent genetic studies in HCC included the MMR genes. Although these genes have been extensively investigated by cytogenetic technology, such as genomic hybridization and PCR techniques (10–17), few immunohistochemical studies were reported (18–22).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of mismatch repair genes (hMSH2 and hMLH1) in hepatocellular carcinoma in Egypt

Helal

Khamis

Elsharkawy

et al. 2010

APMIS

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Egypt has the highest prevalence rate of hepatitis C virus (HCV) infection in the world. HCV contributes to the development of about 70% of hepatocellular carcinoma (HCC) cases. Understanding the molecular basis of hepatocarcinogenesis is important for planning the therapeutic regimen for HCC patients. To clarify the possible role of mismatch repair (MMR) genes in HCV-related HCC, we studied 50 HCV-related HCC specimens (28 of which were with adjacent non-cancerous cirrhotic liver tissue, ANCLT) and 30 specimens of chronic liver disease (CLD) with no evidence of HCC. All cases were examined immunohistochemically to demonstrate the protein expression of hMSH2 and hMLH1. Thirty-two (64%) and 35 (70%) of the HCC cases revealed reduced expression of hMSH2 and hMLH1, respectively. Reduced expression of both the proteins was obtained in 26 (52%) of the HCC cases. The expression of hMSH2 and hMLH1 was reduced in 53.6% and 64.3% of ANCLT cases, respectively, with no significant difference between HCC and ANCLT. All 30 specimens of CLD had preserved expression of hMSH2 and hMLH1. Multivariate analysis showed that the reduced expression of hMSH2 or hMLH1 was significantly associated with higher grades of the tumor (p = 0.002 and 0.02, respectively).The relationships of these MMR genes with other clinicopathologic factors were not significant. Reduced expression of hMSH2 and hMLH1 in both HCC and ANCLT suggests that this event occurs at early stages of HCV-related hepatocarcinogenesis. Moreover, the significant association between reduced expression of both MMR genes and poor histologic grades of the tumor claims that these proteins are involved in the process of cancer progression.

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“… 16 found MSI in cirrhotic liver to be almost three times higher than in liver with chronic hepatitis. In contrast, many other studies from Italy, 18,19 Taiwan, 20 Japan, 21 South Africa 22 and the USA 23 found little evidence of MSI in HCC of patients with chronic liver disease.…”

Section: Discussionmentioning

confidence: 85%

“…Kondo et al 16 found MSI in cirrhotic liver to be almost three times higher than in liver with chronic hepatitis. In contrast, many other studies from Italy, 18,19 Taiwan, 20 Japan, 21 South Africa 22 24 as well as five additional markers (one mononucleotide and four dinucleotide repeat markers). High MSI was defined as the presence of a shift in more than 30% of the markers.…”

Section: Discussionmentioning

confidence: 92%

Microsatellite instability in hepatocellular carcinoma in non‐cirrhotic liver in patients older than 60 years

Togni

Bagla

Muiesan

et al. 2009

Hepatology Research

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Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients

Cited by 5 publications

References 15 publications

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicatesSEC63as potential target gene in hepatocarcinogenesis

Immunohistochemical expression of mismatch repair genes (hMSH2 and hMLH1) in hepatocellular carcinoma in Egypt

Microsatellite instability in hepatocellular carcinoma in non‐cirrhotic liver in patients older than 60 years

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