Lack of evidence in neurite growth in the gerbil hippocampal CA1 region 15 days after transient forebrain ischemia

Yoo, Dae Young; Kwon, Hyun Jung; Lee, Kwon Young; Jung, Hyo Young; Kim, Jong Whi; Park, Joon Ha; Choi, Jung Hoon; Yoon, Yeo Sung; Won, Moo‐Ho; Kim, Dae Won; Hwang, In Koo

doi:10.1080/19768354.2016.1226950

Cited by 1 publication

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References 30 publications

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“…It is well-known that extensive neuronal death and dendritic damage occur in the CA1 hippocampal region, commencing 2 to 3 days after transient forebrain ischemia and reaching their maximal effects within 1~2 weeks [27,53,58]. Furthermore, re-generative processes such as neurite growth are lacking in the CA1 hippocampus 15 days after ischemia [59]. Thus, it is likely that the temporal pattern of reactive NG2 glia phenotypes in the stratum radiatum overlaps with the period of ongoing dendrite degeneration observed in pyramidal neurons, resulting from ischemic insults to this layer.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

et al. 2020

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Neuron-glial antigen-2 (NG2) glia undergo proliferation and morphological changes following brain insults. Here, we show that NG2 glia is activated in a characteristic time-and layer-specific manner in the ischemia-vulnerable CA1 region of the rat hippocampus. Resting NG2 glia of the pyramidal cell layer (somatic region) shared morphological features with those of the neighboring dendritic stratum radiatum. During the postischemic period, reactive NG2 glia of the pyramidal cell layer exhibited shortened, scarcely branched processes, while those of the stratum radiatum had multiple branching processes with their arborization being almost indiscernible 7~14 days after reperfusion. Immunoelectron microscopy demonstrated that NG2 immunoreactivity was specifically associated with the plasma membrane and the adjacent extracellular matrix of NG2 glia in the stratum radiatum at 14 days. NG2 glia also exhibited differences in their numbers and proliferation profiles in the two examined hippocampal strata after ischemia. In addition, induced NG2 expression in activated microglia/macrophages exhibited a characteristic strata-dependent pattern in the ischemic CA1 hippocampus. NG2 induction was prominent in macrophage-like phenotypes which were predominantly localized in the pyramidal cell layer, compared with activated stellate microglial cells in the stratum radiatum. Thus, our data demonstrate that activation of NG2 glia and the induction of NG2 expression in activated microglia/macrophages occur in a distinct time-and layer-specific manner in the ischemic CA1 hippocampus. These characteristic profiles of reactive NG2 glia could be secondary to the degeneration processes occurring in the cell bodies or dendritic domains of hippocampal CA1 pyramidal neurons after ischemic insults.

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Section: Discussionmentioning

confidence: 99%

Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

et al. 2020

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Lack of evidence in neurite growth in the gerbil hippocampal CA1 region 15 days after transient forebrain ischemia

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles Lack of evidence in neurite growth in the gerbil hippocampal CA1 region 15 days after transient forebrain ischemia

Cited by 1 publication

References 30 publications

Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

Spatiotemporal Profile and Morphological Changes of NG2 Glia in the CA1 Region of the Rat Hippocampus after Transient Forebrain Ischemia

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