Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms

Jönsson, Erik G.; Mm, Nöthen; Jp, Gustavsson; Neidt, Helge; Brené, Stefan; Tylec, A.; Propping, Peter; Gc, Sedvall

doi:10.1176/ajp.154.5.697

Cited by 111 publications

(2 citation statements)

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“…However, our present study of total, male or female subjects identified no significant association between any of the 3 tested SNPs in the NTR1 gene, which is closely connected to the dopamine system, and NS scores, suggesting that NTR1 is not a defining factor in the NS temperament dimension, at least in the Chinese Han genetic background. In fact, the current results are consistent with those of many previous studies that found no associations between DRD2 [44], DRD4 [44,45,46,47,48], and dopamine transporter 1 [47] gene variants and NS in different healthy populations, and that did not replicate the results that variants in the genes encoding proteins in the dopamine system were related to NS trait scores.…”

Section: Discussionsupporting

confidence: 85%

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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Aims: Neurotensin receptor 1 (NTR1) is a neurotensin (NT) receptor subtype with a high affinity for NT. NT and NTR1 signaling are involved in modulating the dopamine system. Individual variations in the dopamine system have been demonstrated to determine certain dimensions of personality, but no studies have thus far investigated the involvement of the NTR1 in the biological determination of personality. We therefore examined this link in a Chinese Han population. Methods: We genotyped 3 single nucleotide polymorphisms (SNPs) (rs6090453C/G, rs6011914C/G, and rs2427422A/G) of the NTR1 gene and collected the data about the personality traits of novelty seeking (NS), harm avoidance (HA), and reward dependence (RD), as well as their subscales (measured by the Tridimensional Personality Questionnaire), in 575 healthy Chinese Han subjects. Then we examined the association between the 3 NTR1 gene polymorphisms and each personality trait. Results: There were significant differences in the HA2, HA3 and RD1 scores between rs6090453C/G genotypes (F = 3.425, 5.651, 4.054, p = 0.033, 0.004, 0.018, respectively), in the HA2 and total RD scores between rs6011914C/G genotypes (F = 4.080, 3.712, p = 0.017, 0.025, respectively), and in the total RD (χ² = 7.301, p = 0.026) and RD3 (F = 4.119, p = 0.017) scores between the rs2427422A/G genotypes. There were significant male-specific differences in the RD1 scores between the rs6090453C/G genotypes (F = 3.334, p = 0.037), in the total HA (F = 3.043, p = 0.049), HA2 (F = 4.472, p = 0.012) and RD3 (χ² = 6.997, p = 0.030) scores between the rs6011914C/G genotypes, and in the HA2 (F = 3.177, p = 0.043), total RD (χ² = 7.032, p = 0.030), and RD3 (F = 4.563, p = 0.011) scores between the rs2427422A/G genotypes. We also demonstrated a significant female-specific difference in the total RD scores between the rs6011914C/G genotypes (F = 3.677, p = 0.026). There was no significant difference in the total NS and subscale scores between the genotypes of all 3 SNPs (all p > 0.05). Conclusions: The variations in the NTR1 gene were involved in the biological mechanisms of HA and RD personality traits; however, the effect is influenced by gender.

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Section: Discussionsupporting

confidence: 85%

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Huang

Zhang

et al. 2013

Neuropsychobiology

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“…Simultaneously, Benjamine et al5 reported an association between the same DRD4 polymorphism and the excitement-seeking item measured by the NEO PI-R (Revised NEO Personality Inventory) questionnaire. Some further studies have found a relation between the long DRD4 VNTR allele and a higher NS score,6,7 while others have not found such an association 8,9…”

Section: Introductionmentioning

confidence: 95%

Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

Kim

et al. 2006

Yonsei Med J

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Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.

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Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study

et al. 1998

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Although it is well-established that genetic variation is important in causing individual differences in many human personality traits or based on family, twin, and adoption studies, the first reports that specific genetic polymorphisms might influence a normal dimension of personality were only recently published. Specifically, two studies have described significant associations between a dopamine D4 receptor (D4DR) exon III 48-base pair (bp) insertion/deletion polymorphism and the personality traits of novelty-seeking and positive emotional experience [Benjamin et al. (1996): Nat Genet 12: 81-84; Ebstein et al. (1996): Nat Genet 12:78-80]. The present study was undertaken to attempt to replicate these important and heuristic initial findings. Personality questionnaires measuring novelty-seeking and positive emotional experience were administered to 306 male and female young adult twins (monozygotic 92 pairs, dizygotic 61 pairs) from the general population, 281 of whom were genotyped for D4DR exon I and III polymorphisms. No significant associations were observed between novelty-seeking or positive emotional experience and these D4DR polymorphisms. This failure to replicate the initial reports seems unlikely to represent measurement or genetic differences across studies, although environmental differences may be possible. Adequate statistical power in the present study suggests that these results are unlikely to be statistical "false negatives" and instead may reduce confidence in the generality of the initial positive findings.

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Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms

Abstract: The previously reported association between dopamine D4 receptor alleles and novelty seeking was not replicated. Possible reasons for this include differences in personality inventories, ethnicity, and type I or type II errors.

Cited by 111 publications

References 9 publications

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals

Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study

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