Lack of Evidence for a Role of Mast Cell Degranulation in Acute Hypoxia /Reoxygenation-induced Injury in the Isolated Rat Heart

Haaster, Charles M.C.J. van; Engels, W.; Duijvestijn, A. M.; Lemmens, P. J. M. R.; Hornstra, Gerard; Vusse, Ger J.

doi:10.1006/jmcc.1996.0034

Cited by 12 publications

(14 citation statements)

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“…Tumor hypoxia resulted in rapid mast cell degranulation, and this increases the reactive oxygen species, leukocyte adherence/emigration and vascular permeability. 8 Upon degranulation, mediators are released from mast cells including tryptase, chymase, cathepsin G, histamine and VEGF. 1,2,8,27 In this study, histamine, tryptase and VEGF were secreted by activated mast cells.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

“…8 Upon degranulation, mediators are released from mast cells including tryptase, chymase, cathepsin G, histamine and VEGF. 1,2,8,27 In this study, histamine, tryptase and VEGF were secreted by activated mast cells. HIF-1a was upregulated at the early phase of the PCA reaction.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

“…28 Mast cells are an abundant source of angiogenic factors such as VEGF, histamine, chymase and tryptase. 1,8,27 In the tumor microenvironment, histamine-containing mast cells are increased. 8 Histamine enhances angiogenesis in the inflammatory granulation tissue via the induction of VEGF production.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

“…1,8,27 In the tumor microenvironment, histamine-containing mast cells are increased. 8 Histamine enhances angiogenesis in the inflammatory granulation tissue via the induction of VEGF production. In HDC(À/À) mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC (þ/þ) mice.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

“…7 In the tumor microenvironment, histamine-containing mast cells are increased and the increased mast cells contribute to a significant extent to acute hypoxia-induced injury. 8,9 However, although many studies have shown that mast cells promote tumor angiogenesis and tumor growth because of their properties as inflammatory cells, the roles of mast cells in tumor growth have not yet been completely understood.…”

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confidence: 99%

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The critical role of mast cell‐derived hypoxia‐inducible factor‐1α in human and mice melanoma growth

Jeong

Nam

et al. 2012

Intl Journal of Cancer

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Mast cells play an important role in tumorigenesis. Histamine released from mast cells stimulates new vessel formation by acting through the histamine1 (H1) receptor. Despite the evidence of the role of mast cells in tumor growth and angiogenesis, the potential mechanism remains to be elucidated. Therefore, we investigated the role of mast cell-derived HIF-1a in melanoma growth. Here, we identify that the most positive cells for HIF-1a staining are seen in mast cells of human and animal melanoma tissue. The number of the stromal cell types (fibroblasts, macrophages and endothelial cells) was also increased in melanoma tissues. In activated bone marrow-derived mast cells (BMMCs), expressions of HIF-1a and VEGF were increased. Histamine also induced the expressions of HIF-1a and VEGF in BMMCs. H1 receptor antagonists significantly improved overall survival rates and substantially suppressed tumor growth as well as the infiltration of mast cells and levels of VEGF through the inhibition of HIF-1a expression in B16F10 melanoma-bearing mice. Furthermore, the injection of HIF-1a depleted BMMCs markedly inhibited the growth of tumors and migration of mast cells and increased the survival rate of the mice. These findings emphasize that the growth of melanoma can actually be exacerbated by mast cell-derived HIF-1a. In aggregate, our results reveal a novel role for mast cell-derived HIF-1a in the melanoma microenvironment and have important implications for the design of therapeutic strategies.

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Section: Cancer Cell Biologymentioning

confidence: 99%

Section: Cancer Cell Biologymentioning

confidence: 99%

Section: Cancer Cell Biologymentioning

confidence: 99%

Section: Cancer Cell Biologymentioning

confidence: 99%

mentioning

confidence: 99%

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The critical role of mast cell‐derived hypoxia‐inducible factor‐1α in human and mice melanoma growth

Jeong

Nam

et al. 2012

Intl Journal of Cancer

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Ischaemic preconditioning and mast cell histamine release: microdialysis of isolated rat hearts

Davani

Muret

Royer

et al. 2002

Pharmacological Research

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Antigen-evoked mast cell degranulation in the isolated rat heart: No effect on subsequent ischemia-reperfusion induced damage

Engels

Haaster

Vleeming

et al. 1997

Inflammation Research

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In the present study, the possible role of mast cells in ischemia/reperfusion-induced myocardial injury was evaluated in the isolated 'mast cell depleted' rat heart. Hearts isolated from sensitized and non-sensitized rats were perfused according to Langendorff. After 30 min of normoxic perfusion, hearts were challenged with antigen, a procedure which is known to result in a massive mast cell degranulation in sensitized hearts. After another 20 min, both 'mast cell depleted' and control hearts were subjected to 30 min of ischemia followed by 30 min of reperfusion. The release of lactate dehydrogenase (LDH) was determined, to quantitate the extent of irreversible injury of cardiomyocytes. Histamine release was measured to establish mast cell degranulation. Coronary flow (CF) and left ventricular developed pressure (LVDP) were monitored to study the consequences of the procedures on hemodynamic recovery. It was found that both CF and LVDP significantly increased during the first min after antigen challenge. These changes were accompanied by an almost complete degranulation of cardiac mast cells. The increase in CF and LVDP values were rapidly followed by a decrease, reaching minimal values of 159 +/- 4% and 85 +/- 4% of those before administration of antigen, respectively, at 2-3 min after antigen challenge. No effect of antigen challenge on LDH release were found indicating that mast cell degranulation did not compromise myocyte integrity. During reperfusion following 30 min of ischemia both the increase in CF and LVDP in 'mast cell-depleted' hearts were not significantly different from those in control (non-sensitized) hearts. Similarly, at the end of the reperfusion-phase, CF and LVDP values in sensitized hearts were comparable to those in control hearts. Reperfusion results in increased LDH release, which at no point in time was significantly different between sensitized and non-sensitized hearts. In non-sensitized hearts histamine release during the reperfusion phase was not detectable. Therefore, the results indicate that in the isolated rat heart, mast cells are most likely not involved in acute ischemia/reperfusion-induced myocardial injury.

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Lack of Evidence for a Role of Mast Cell Degranulation in Acute Hypoxia /Reoxygenation-induced Injury in the Isolated Rat Heart

Cited by 12 publications

References 0 publications

The critical role of mast cell‐derived hypoxia‐inducible factor‐1α in human and mice melanoma growth

The critical role of mast cell‐derived hypoxia‐inducible factor‐1α in human and mice melanoma growth

Ischaemic preconditioning and mast cell histamine release: microdialysis of isolated rat hearts

Antigen-evoked mast cell degranulation in the isolated rat heart: No effect on subsequent ischemia-reperfusion induced damage

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