Lack of Effects of Prenatal Exposure to Lidocaine on Development of Behavior in Rats

Teiling, Anna; Mohammed, Abdul K.; Minor, Bruce G.; Järbe, Torbjörn U. C.; Hiltunen, Arto J.; Archer, Trevor

doi:10.1213/00000539-198706000-00009

Cited by 11 publications

(1 citation statement)

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“…More recently, lidocaine concentrations superior to 20 mg/L (around 74 mM, and higher than clinical relevant concentrations) have been shown to induce teratogenic effects on zebrafish embryos (2 hpf) exposed for 48 h (Lomba et al 2019). Still, there are contradictory results between studies with different rat strains (Teiling et al 1987;Smith et al 1989), which may reveal an effect dependent on species and/or strain. Thus, some groups of people may be susceptible to lidocaine teratogenic effects, which needs further genetic evaluation.…”

Section: 6: Local Anestheticsmentioning

confidence: 99%

Review on the use of zebrafish embryos to study the effects of anesthetics during early development

Félix

Coimbra

Valentim

et al. 2019

Critical Reviews in Toxicology

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Over the years, the potential toxicity of anesthetics has raised serious concerns about its safe use during pregnancy. As evidence emerged from research in animal models, showing that some anesthetic drugs are potential teratogenic, the determination of the risk of exposures to anesthetic drugs at early life stages became mandatory. However, due to inaccessibility and ethical constrains related to experimental conditions, the use of early life stages in mammalian models is limited. In this regard, some animal and nonanimal models have been suggested to surpass mammalian use in experimentation. Among them, the zebrafish embryo test has been recognized as a promising alternative in toxicology research, as well as an inexpensive and practical test. Substantial information collected from developmental research following compounds exposure, has contributed to the application of zebrafish assays in research, although only a few studies have focused on the use of early life stages of zebrafish to evaluate the developmental effects of anesthetics. Based on the recent advances of science and technology, there is a clear potential for zebrafish early life stages to provide new insights into anesthetics teratogenicity. This review provides an overview of recent anesthesia research using zebrafish embryos, demonstrating its usefulness to the anesthesia field, discussing the recent findings on various aspects related to the effects of anesthetics during early life development and the strengths and limitations of this model system.

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Section: 6: Local Anestheticsmentioning

confidence: 99%