Lack of effects of oxolinic acid on spermatogenesis in young adult and aged Wistar rats

Yoshida, Midori; Kitani, Takako; Takenaka, Akiko; Kudoh, Kayoko; Si, Katsuda; Taya, Kazuyoshi; Kurokawa, Yuji; Maekawa, Akihiko

doi:10.1016/s0278-6915(02)00168-0

Cited by 30 publications

(16 citation statements)

References 16 publications

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“…A decreased testosterone level is also one of the indicators of chemical toxicity to the reproductive system [46]. In the present study, serum testosterone in the offspring of the high-dose treatment group markedly decreased during the prepubertal, postpubertal, and adulthood periods.…”

Section: Discussionsupporting

confidence: 53%

Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Dorostghoal

Majd

Nooraei

2012

Clin Exp Reprod Med

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ObjectiveConcerns are growing about the decrease in male reproductive health. Caffeine is one of the popular nutrients that has been implicated as a risk factor for infertility. In the present study, we examined whether in utero and lactational exposure to caffeine affects the reproductive function of the offspring of rats.MethodsPregnant rats received caffeine via drinking water during gestation (26 and 45 mg/kg) and lactation (25 and 35 mg/kg). Body and reproductive organ weight, seminiferous tubule diameter, germinal epithelium height, sperm parameters, fertility rate, number of implantations, and testosterone level of the offspring were assessed from birth to adulthood.ResultsSignificant dose-related decreases were observed in the body and reproductive organ weight, seminiferous tubule diameter, and germinal epithelium height of the offspring. Sperm density had declined significantly in offspring of the low-dose and high-dose groups, by 8.81% and 19.97%, respectively, by postnatal day 150. The number of viable fetuses had decreased significantly in females mated with male offspring of the high-dose group at postnatal days 60, 90, 120, and 150. There were also significant reductions in testosterone levels of high-dose group offspring from birth to postnatal day 150.ConclusionIt is concluded that maternal caffeine consumption impairs gonadal development and has long-term adverse effects on the reproductive efficiency of male offspring rats.

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Section: Discussionsupporting

confidence: 53%

Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Dorostghoal

Majd

Nooraei

2012

Clin Exp Reprod Med

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“…The decrease in the testis weight observed in the present study is in consonance with earlier reports (Smith et al ., ; Wang et al ., ; Hamadouche et al ., ; Sainath et al ., ). The reduction in testosterone levels that was found in lead‐treated rats is also one of the indicators of the chemical toxicity on reproductive system (Yoshida et al ., ). It has been suggested that the adequate bioavailability of testosterone plays an important role in the structural and functional integrity of reproductive organs (Mann, ) and the decrease in weights of these organs could be due to inadequate circulating male hormone.…”

Section: Discussionmentioning

confidence: 97%

Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

2013

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In recent years, the clinical importance of herbal drugs has received considerable attention in reducing free radical-induced tissue injury. Oxidative stress has been proposed as a possible mechanism involved in lead toxicity that causes reproductive system failure in both human and animals. Fumaria parviflora L., a traditional herb, has been used to cure various ailments in Persian folk medicine. This study was carried out to investigate whether ethanolic extract of F. parviflora leaves could protect the male rats against lead-induced testicular oxidative stress. Adult Wistar rats were treated with 0.1% lead acetate in drinking water with or without 200 mg kg day(-1) F. parviflora extract via gavage for 70 days. Lead acetate treatment resulted in significant reduction in testis weight, seminiferous tubules diameter, epididymal sperm count, serum testosterone level, testicular content of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Moreover, significant elevation was observed in content of malondialdehyde (MDA) in lead-treated rats. However, co-administration of F. parviflora extract showed a significant increase in selected reproductive parameters in lead-treated rats. The results indicated that ethanolic extract of F. parviflora leaves has a potential to restore the suppressed reproduction associated with lead exposure and prevented lead-induced testicular toxicity in male Wistar rats.

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“…Testosterone is secreted by the Leydig cells and essential for spermatogenesis. Decreased testosterone concentration is an indicator of chemical toxicity in male reproduction (Yoshida, Kitani, Takenaka, Kudoh, & Katsuda, ). The present result indicates that administration of tramadol decreased serum testosterone concentration.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

et al. 2019

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Tramadol is widely abused in Nigeria and has been reported to cause fertility decline via testicular oxidative stress. This study investigated the effect of vitamin E, an antioxidant on some reproductive parameters in male Wistar rats administered tramadol. Twenty male Wistar rats (180-200 g) were randomly assigned into four groups (n = 5) thus: Control (0.2 ml vehicle: olive oil), tramadol-treated (20 mg/kg of tramadol), vitamin E-treated (100 mg/kg of vitamin E) and tramadol + vitamin Etreated (received tramadol and vitamin E) groups. Drugs were administered orally and daily for 28 days. Sperm count, Johnsen's score, germinal epithelial height and serum testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH) concentrations were significantly (p < .05) decreased in tramadol-treated and tramadol + vitamin E compared with control and vitamin E-treated groups. Sperm motility, morphology, viability, seminiferous tubular diameter, Leydig cell count, Sertoli cell count and malondialdehyde, superoxide dismutase, glutathione peroxidase and catalase concentrations were not significantly different among the groups. Histology of testis and epididymis in all groups showed no toxicity but decreased sperm population in tramadol-treated and tramadol + vitamin E-treated groups. Tramadol did not cause testicular oxidative stress but impaired testicular function by suppressing testosterone, FSH and LH secretion. Vitamin E administration could not attenuate this impairment in testicular function. K E Y W O R D S spermatogenesis, testis, testosterone, tramadol, vitamin E How to cite this article: Udefa AL, Beshel FN, Nwangwa JN, et al. Vitamin E administration does not ameliorate tramadolassociated impairment of testicular function in Wistar rats.

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Lack of effects of oxolinic acid on spermatogenesis in young adult and aged Wistar rats

Cited by 30 publications

References 16 publications

Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

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