Lack of effects of beta sympathetic blockade on the metabolic and respiratory responses to carbohydrate feeding

Zwillich, Clifford W.; Martin, Barbara J.; Hofeldt, Fred D.; Charles, A. F.; Subryan, V. L.; Burman, Kenneth D.

doi:10.1016/0026-0495(81)90179-7

Cited by 43 publications

(17 citation statements)

References 26 publications

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“…The present study is, therefore, in agree ment with the findings ofZwillich et al [15], i.e. no causal relationship was detected be tween SNS activity and the thermic effect of meal feeding.…”

Section: Discussionsupporting

confidence: 82%

“…Zwillich et al [15] administered to 6 men either an 80 mg oral dose of propranolol or a placebo every 6 h for 3 days prior to the measurement of glucoseinduced thermogenesis (GIT). A liquid meal of 250 g glucose in 1 litre water (energy value 3.9 JM) exerted a GIT of 17% above baseline in both studies, so propranolol appeared to have no effect when administered chronical ly.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Propranolol on the Acute Thermic Effect of Feeding in Man

Morgan

York

1986

Ann Nutr Metab

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The influence of a β-adrenergic blocker on the thermic effect of feeding (TEF) a meal was investigated in 7 healthy male volunteers. Metabolic rate (MR) was measured before and for 180 min after the consumption of 2.0 MJ ‘Ensure’ (Abbott Laboratories, Queensbor-ough, Kent, UK); there were 14, 33 and 53% of energy from protein, fat and carbohydrate, respectively. On one occasion propranolol (ICI pic, Macclesfield, Ches., UK) was administered intravenously at 0.1 mg/kg body weight at meal feeding. On the second occasion a similar volume of saline was infused. Serial blood samples (10 ml) were collected before and at 30-min intervals for 180 min after meal feeding. Mean ( ± SD) resting MR was 104 (13) and 116 (11) kJ/kg and MR increased by 12.8% and 10.8% after the test meal with and without propranolol, respectively. These differences were not significant. The postprandial changes in serum glucose and triiodothyronine were similar in the two trials. The magnitude of the rise of serum insulin was similar in the two trials, but the pattern was not. β-Adrenergenic blockade resulted in an early peak in insulin output at 30 min compared with 60 min for the control trial. We conclude that propranolol had no influence on TEF in this study.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Influence of Propranolol on the Acute Thermic Effect of Feeding in Man

Morgan

York

1986

Ann Nutr Metab

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“…In most studies, the administration of a P-blocker does not affect TEF measured after the oral ingestion of a meal, whether this is a mixed meal (2,65,88) or a carbohydrate meal (101,102). However, Astrup et al did observe a decrease in TEF during propranolol infusion after a carbohydrate-rich, mixed meal (6), whereas one recent study reported a reduced TEF of a mixed meal during the administration of a P-blocker (23).…”

Section: Experimental Backgroundmentioning

confidence: 99%

The Thermic Effect of Food and Obesity: A Critical Review

1997

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DE JONGE, LILIAN, GEORGE BRAY. The thermic effect of food and obesity: A critical review. Obes Res. 199735622-631.This review has examined the factors that influence the thermic effect of food (TEF) by evaluating 49 studies that have compared subjects who are obese with those who are lean. Meal size, meal composition, the nature of the previous diet, insulin resistance, physical activity, and ageing influence TEF. In the studies of individuals who are obese or lean, of those who used intravenous glucose infusions, all but one found an impaired thermic response. A total of 29 out of 49 studies of individuals of normal weight or with obesity were identified where there was no difference in age between the groups, and where the subjects who were "overweight" were clearly obese. Of these 29,22 reported a statistically significant reduction in TEF, 3 studies were not designed to look primarily at the effect of obesity on TEF, and the other 4 may not have had sufficiently palatable meals. From this review, we conclude that the reduction of TEF in obesity is related to the degree of insulin resistance, which may be influenced by a low level of sympathetic activity.

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“…It is tempting to speculate that the absence of any rise in heart rate in diabetic patients during the test was due to the lack of change in sympathetic nervous activity. However, we hesitate to draw this conclusion because neither we [7] nor Zwillich et al [39] could inhibit the increase in heart rate after insulin and glucose administration by beta-adrenoceptor blockade.…”

Section: Effects Of Glucose Administration On Na Releasementioning

confidence: 84%

Acute effects of insulin on cardiovascular function and noradrenaline uptake and release

Christensen

1983

Diabetologia

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Lack of effects of beta sympathetic blockade on the metabolic and respiratory responses to carbohydrate feeding

Cited by 43 publications

References 26 publications

Influence of Propranolol on the Acute Thermic Effect of Feeding in Man

Influence of Propranolol on the Acute Thermic Effect of Feeding in Man

The Thermic Effect of Food and Obesity: A Critical Review

Acute effects of insulin on cardiovascular function and noradrenaline uptake and release

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