Lack of effect of vitamin D<sub>3</sub>supplementation in autism: a 20-week, placebo-controlled RCT

Kerley, Conor P; Power, Clare; Gallagher, Louise; Coghlan, David

doi:10.1136/archdischild-2017-312783

Cited by 60 publications

(64 citation statements)

References 42 publications

(18 reference statements)

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“…One of the first randomized controlled trials (RCTs) involving a high dose vitamin D supplementation in child ASD patients showed significant improvement in symptoms 53). However, another RCT involving a lower dose vitamin D supplementation in child ASD patients failed to show consistent benefits 54). Furthermore, a recent study showed low serum levels of vitamin D in 60 patients with ASD 55).…”

Section: Immunomodulatory Treatmentmentioning

confidence: 99%

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Kim

Hong

Bae

2018

Clin Psychopharmacol Neurosci

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Autism spectrum disorder is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest. Lately, maternal immune activation and micgroglial dysfunction in the developing brain have been gaining mounting evidence and leading to studies of various novel agents as potential treatment options. A few immunomodulatory treatment options—luteolin, minocycline, suramin, vitamin D, gut microbiota—are discussed in the current article, regarding the current understanding of their mechanisms and evidence for potential clinical use. More studies are warranted to understand their exact mechanisms of action and to verify efficacy and safety in human subjects.

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Section: Immunomodulatory Treatmentmentioning

confidence: 99%

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Kim

Hong

Bae

2018

Clin Psychopharmacol Neurosci

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“…Demographic information and additional details extracted from the included studies are summarized in Table 1. The Cochrane Handbook for Systematic Reviews of Interventions was used to evaluate the studies, except two studies: Kerley's study [55], which did not describe the randomization algorithm, and Fang's analysis [52], which did not describe the specific process and may have had other biases. Most studies qualified by meeting the following requirements: (1) provided clear inclusion and exclusion criteria, (2) proposed a randomization methodology, (3) stated allocation concealment, (4) used a double-blind approach in all RCT groups, and (5) demonstrated complete outcome data (Figs.…”

Section: Publication Biasmentioning

confidence: 99%

Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis

Song

Luo

Jiang

et al. 2020

Clin Psychopharmacol Neurosci

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Objective: We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder. Methods: We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation. Results: There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03). Conclusion: Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.

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“…An randomized clinical trial (RCT) of VD 3 supplementation on ASD showed a significant increase of 25(OH)D in serum in the treatment group, but not in the control group, with only improvement in self-care and no significant improvement in behavior scales. 114 However, several open-label trials 115,116 and case studies 117,118 provide additional evidence that VD3 supplementation could significantly improve the clinical behavioral aspects of children with ASD.…”

Section: Oxytocinmentioning

confidence: 99%

Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

Zhang

2019

CNS Spectr.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by deficits in social interactions and perseverative and stereotypical behavior. Growing evidence points toward a critical role for synaptic dysfunction in the onset of ASD, and synaptic function is influenced by glial cells. Considering the evidence that neuroinflammation in ASD is mediated by glial cells, one hypothesis is that reactive glial cells, under inflammatory conditions, contribute to the loss of synaptic functions and trigger ASD. Ongoing pharmacological treatments for ASD, including oxytocin, vitamin D, sulforaphane, and resveratrol, are promising and are shown to lead to improvements in behavioral performance in ASD. More importantly, their pharmacological mechanisms are closely related to anti-inflammation and synaptic protection. We focus this review on the hypothesis that synaptic dysfunction caused by reactive glial cells would lead to ASD, and discuss the potentials of antineuroinflammatory therapy for ASD.

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Lack of effect of vitamin D₃supplementation in autism: a 20-week, placebo-controlled RCT

Abstract: NCT02508922.

Cited by 60 publications

References 42 publications

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis

Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

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Lack of effect of vitamin D3supplementation in autism: a 20-week, placebo-controlled RCT

Abstract: NCT02508922.

Cited by 60 publications

References 42 publications

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Microglia and Autism Spectrum Disorder: Overview of Current Evidence and Novel Immunomodulatory Treatment Options

Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis

Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

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Product

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Lack of effect of vitamin D₃supplementation in autism: a 20-week, placebo-controlled RCT