Lack of Effect of Treating<i>Helicobacter pylori</i>Infection in Patients with Nonulcer Dyspepsia

Blum, A. L.; Talley, Nicholas J.; O’Moráin, Colm; Zanten, Sander Veldhuyzen van; Labenz, Joachim; Stolte, Manfred; Louw, J. A.; Stubberöd, A; Theodórs, Ásgeir; Sundin, Marie; Bolling–Sternevald, Elisabeth; Junghard, Ola

doi:10.1056/nejm199812243392602

Cited by 432 publications

(207 citation statements)

References 24 publications

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“…Patients with Helicobacter pylori infection were also excluded, because the role of this organism in the pathogenesis of functional dyspepsia is still somewhat controversial. 20,21 Patients with concomitant symptoms consistent with IBS were not excluded, provided that their FD symptoms were more predominant. The study was approved by the local ethics committee, and all patients gave written informed consent.…”

Section: Patientsmentioning

confidence: 99%

Long-term improvement in functional dyspepsia using hypnotherapy

Calvert¹,

Houghton²,

Cooper³

et al. 2002

Gastroenterology

223

164

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Section: Patientsmentioning

confidence: 99%

Long-term improvement in functional dyspepsia using hypnotherapy

Calvert¹,

Houghton²,

Cooper³

et al. 2002

Gastroenterology

223

164

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“…In the present study patients with such disorders were excluded and the finding of equally delayed gastric emptying in both genders would support that eating disorders were not present. We did not routinely test for H pylori in this study, but there is no evidence that Hp infection has any relationship with symptoms and delayed gastric emptying in functional dyspepsia [45][46][47][48][49] . Thus, it seems unlikely that knowledge of the Hp status would have altered the conclusions of the present study.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 96%

Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

Pallotta

Pezzotti²,

Calabrese³

et al. 2005

WJG

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Abstract Abstract Abstract AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains unclear. This study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional dyspepsia. METHODS:In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultrasonography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression analysis. RESULTS:Delayed gastric emptying was detected in 39.8% of the patients. Postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%. CONCLUSION:In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying, and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying.

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“…Die Resultate der Arbeit von McColl [41] in Glasgow belegen in bezug auf die Beschwerdefreiheit einen Vorteil für die Eradikation mit Omeprazol plus Antibiotikum. Anders die Arbeit von Blum [42], die nach einem Jahr keinen signifikanten Unterschied zur alleinigen Omeprazol-Therapie zutage fördert.…”

Section: Dyspepsie Ulkuserkrankungen -Helicobacter Pyloriunclassified

Gastro-Higlights '99

2000

Schweiz Ärzteztg

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Lack of Effect of TreatingHelicobacter pyloriInfection in Patients with Nonulcer Dyspepsia

Abstract: In patients with nonulcer dyspepsia, the eradication of H. pylori infection is not likely to relieve symptoms.

Cited by 432 publications

References 24 publications

Long-term improvement in functional dyspepsia using hypnotherapy

Long-term improvement in functional dyspepsia using hypnotherapy

Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

Gastro-Higlights '99

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