Lack of effect of nitrogen dioxide exposure on heart rate variability in patients with stable coronary heart disease and impaired left ventricular systolic function

Scaife, Alison; Barclay, Justin L.; Hillis, Graham S.; Srinivasan, Janaki; Macdonald, David W.; Ross, John; Ayres, Jon G.

doi:10.1136/oemed-2011-100126

Cited by 13 publications

(16 citation statements)

References 37 publications

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“…This was interpreted as strongly supporting the view that fine particles, and not NO 2 , were driving the previously reported cardiovascular effects, especially as NO 2 concentrations increased almost five-fold with the particle trap. Further evidence, suggesting the absence of an acute cardiovascular effect of NO 2 , was reported by Scaife et al (2012). In this study they found no significant changes in heart variability parameters in 18 heart bypass and myocardial infarction patients following exposure to 400 ppb NO 2 for 1 hour.…”

Section: Chamber Studiessupporting

confidence: 45%

“…The human chamber study evidence was also reviewed by the California Environmental Protection Agency Air Resources Board (CARB, 2007) in their assessment of the California NO 2 standard. Since the publication of these reviews, limited NO 2 chamber studies that address lung function and airway inflammation have been performed, and two studies that address cardiovascular end-points have been published (Langrish et al, 2010;Scaife et al, 2012). Therefore, the conclusions that arise from these reviews remain valid for consideration of the current NO 2 standards.…”

Section: Chamber Studiesmentioning

confidence: 99%

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A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Chamber Studiessupporting

confidence: 45%

Section: Chamber Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

View full text Add to dashboard Cite

show abstract

“…Controlled human exposure studies have produced mixed results. Scaife et al reported no association between NO 2 exposure and heart rate, heat rate variability (HRV), ectopic beats, or arrhythmias in adults with stable IHD [128], while Huang et al reported significant associations with HRV in healthy young adults [129]. Riedl et al found no association with coagulation factors, blood pressure, oxygen saturation or cardiovascular symptom scores in individuals with mild asthma [130] and Langrish et al reported no significant associations with measures of fibrinolytic function in healthy males [131].…”

Section: Other Lines Of Evidencementioning

confidence: 99%

Systematic review and meta-analysis of case-crossover and time-series studies of short term outdoor nitrogen dioxide exposure and ischemic heart disease morbidity

et al. 2020

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Background: Nitrogen dioxide (NO 2) is a pervasive urban pollutant originating primarily from vehicle emissions. Ischemic heart disease (IHD) is associated with a considerable public health burden worldwide, but whether NO 2 exposure is causally related to IHD morbidity remains in question. Our objective was to determine whether short term exposure to outdoor NO 2 is causally associated with IHD-related morbidity based on a synthesis of findings from case-crossover and time-series studies. Methods: MEDLINE, Embase, CENTRAL, Global Health and Toxline databases were searched using terms developed by a librarian. Screening, data extraction and risk of bias assessment were completed independently by two reviewers. Conflicts between reviewers were resolved through consensus and/or involvement of a third reviewer. Pooling of results across studies was conducted using random effects models, heterogeneity among included studies was assessed using Cochran's Q and I 2 measures, and sources of heterogeneity were evaluated using metaregression. Sensitivity of pooled estimates to individual studies was examined using Leave One Out analysis and publication bias was evaluated using Funnel plots, Begg's and Egger's tests, and trim and fill.

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“…Some have shown that certain nitrogen oxides, e.g. NO 2 , do not affect heart rate variability at concentrations high for urban background levels and in the absence of other pollutants [56]. Others have shown that ambient NO 2 concentrations were inversely associated with SDNN and positively associated with LF/HF.…”

Section: Discussionmentioning

confidence: 99%

Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study

et al. 2013

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BackgroundWhile air pollution exposures have been linked to cardiovascular outcomes, the contribution from acute gas and particle traffic-related pollutants remains unclear. Using a panel study design with repeated measures, we examined associations between personal exposures to traffic-related air pollutants in Mexico City and changes in heart rate variability (HRV) in a population of researchers aged 22 to 56 years.MethodsParticipants were monitored for approximately 9.5 hours for eight days while operating a mobile laboratory van designed to characterize traffic pollutants while driving in traffic and “chasing” diesel buses. We examined the association between HRV parameters (standard deviation of normal-to-normal intervals (SDNN), power in high frequency (HF) and low frequency (LF), and the LF/HF ratio) and the 5-minute maximum (or average in the case of PM2.5) and 30-, 60-, and 90-minute moving averages of air pollutants (PM2.5, O3, CO, CO2, NO2, NOx, and formaldehyde) using single- and two-pollutant linear mixed-effects models.ResultsShort-term exposure to traffic-related emissions was associated with statistically significant acute changes in HRV. Gaseous pollutants – particularly ozone – were associated with reductions in time and frequency domain components (α = 0.05), while significant positive associations were observed between PM2.5 and SDNN, HF, and LF. For ozone and formaldehyde, negative associations typically increased in magnitude and significance with increasing averaging periods. The associations for CO, CO2, NO2, and NOx were similar with statistically significant associations observed for SDNN, but not HF or LF. In contrast, PM2.5 increased these HRV parameters.ConclusionsResults revealed an association between traffic-related PM exposures and acute changes in HRV in a middle-aged population when PM exposures were relatively low (14 μg/m3) and demonstrate heterogeneity in the effects of different pollutants, with declines in HRV – especially HF – with ozone and formaldehyde exposures, and increases in HRV with PM2.5 exposure. Given that exposure to traffic-related emissions is associated with increased risk of cardiovascular morbidity and mortality, understanding the mechanisms by which traffic-related emissions can cause cardiovascular disease has significant public health relevance.

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Lack of effect of nitrogen dioxide exposure on heart rate variability in patients with stable coronary heart disease and impaired left ventricular systolic function

Cited by 13 publications

References 37 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Systematic review and meta-analysis of case-crossover and time-series studies of short term outdoor nitrogen dioxide exposure and ischemic heart disease morbidity

Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study

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