Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy

Myrup, B.; Rossing, Peter; Jensen, Tonny; Hh, Parving; Hølmer, Gunhild; Gram, Jeppe; Kluft, C.; Jespersen, Jørgen

doi:10.1080/003655101316911387

Cited by 21 publications

(7 citation statements)

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“…Braden [ 38 ] reported a modest platelet inhibitory effect of fish oil in vivo in a canine model of coronary thrombosis. However there exist also other studies [ 39 , 40 , 41 ] showing no effect of omega-3 supplementation on platelet aggregation and thromboxan production.…”

Section: Discussionmentioning

confidence: 95%

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation

et al. 2015

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Background and PurposeSince patients with phenylketonuria (PKU) have to follow a lifelong restriction of natural protein to lower phenylalanine-intake, they never eat fish. This diet may lead to a chronic deficit of omega-3 and omega-6 fatty acids with the risk of early atherosclerotic changes. The aim of the study was to analyse the fatty acid profile of PKU patients and to correlate the results with surrogate markers of early atherosclerotic changes [enhanced carotid intima media thickness (CIMT) and ß-stiffness index] and platelet activation.MethodsIn 43 PKU patients and in 58 healthy controls we prospectively examined the fatty acid profile, CIMT, ß-stiffness index and platelet activation (flow cytometric determination of markers of platelet activation). CIMT was measured bilaterally by ultrasound. CIMT mean was defined as the mean value of the sum of CIMT left and CIMT right.ResultsDespite of lower HDL-cholesterol and higher triglyceride concentrations in the PKU group, there was no significant difference in the omega-6 or omega-3 fatty acid profile, CIMT, ß-stiffness index between both groups. Platelet activation was not enhanced in the PKU group.ConclusionsFish-free diet does not induce early atherosclerotic changes or enhanced platelet activation in PKU patients.

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Section: Discussionmentioning

confidence: 95%

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation

et al. 2015

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“…Randomised controlled trials-Allocation concealment appeared adequate in 34 studies Belluzzi 1996;Bemelmans 2002;Bonnema 1995;Borchgrevink 1966;Connor 1993;Dry 1991;Eritsland 1996;GISSI-P 1999;Greenfield 1993;Hawthorne 1992;Lau 1995;Leaf 1994;Loeschke 1996;Lorenz-Meyer 1996;Maresta 2002;Mate-Jimenez 1991;Milner 1989;Natvig 1968;Nilsen 2001;Reis 1991;Rossing 1996;Sacks (TOHP 1) 1994;Selvais 1995;Singh 1997;Sirtori 1998;Skoldstam 1992;Terano 1999;Thien 1993;Veale 1994;von Schacky 1999). This was generally ascertained following contact with the study author.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…Attempts were made to mask participants in 30 studies Belluzzi 1996;Bemelmans 2002;Bonnema 1995;Borchgrevink 1966;Connor 1993;Dry 1991;Franzen 1993;Geusens 1994;Greenfield 1993;Johansen 1999A;Lau 1995;Leaf 1994;Loeschke 1996;Lorenz-Meyer 1996;Maresta 2002;Natvig 1968;Nilsen 2001;Reis 1991;Rossing 1996;Sacks (TOHP 1) 1994;Sacks (HARP) 1995;Selvais 1995;Sirtori 1998;Thien 1993;Veale 1994;von Schacky 1999), masking was unclear in two studies and not attempted in 16 studies. However, fish oil may have a strong flavour, smell or after-taste, and some studies mentioned attempts to mask allocation using enteric coated capsules (Belluzzi 1996), identical taste in margarines (Bemelmans 2002), orange flavour (Loeschke 1996;Rossing 1996) or peppermint oil (Greenfield 1993) added to fish oil and control capsules or small amounts of fish oil added to the control (Leaf 1994).…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…Masking of providers of care was attempted in 33 studies Belluzzi 1996;Bemelmans 2002;Bonnema 1995;Borchgrevink 1966;Brox 2001;Connor 1993;Dry 1991;Geusens 1994;Greenfield 1993;Hawthorne 1992;Johansen 1999A;Lau 1995;Leaf 1994;Loeschke 1996;Lorenz-Meyer 1996;Maresta 2002;Mate-Jimenez 1991;Natvig 1968;Nilsen 2001;Reis 1991;Rossing 1996;Sacks (HARP) 1995;Sacks (TOHP 1) 1994;Selvais 1995;Singh 1997;Sirtori 1998;Thien 1993;Veale 1994;von Schacky 1999), was unclear in six and not attempted in nine studies.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…Studies were considered to be at low risk of bias where allocation concealment was done, and attempts were made to mask participants, providers and outcome assessors. The 25 studies at low risk of bias included Belluzzi 1996;Bemelmans 2002;Bonnema 1995;Borchgrevink 1966;Connor 1993;Dry 1991;Greenfield 1993;Lau 1995;Leaf 1994;Loeschke 1996;Lorenz-Meyer 1996;Maresta 2002;Natvig 1968;Nilsen 2001;Reis 1991;Rossing 1996;Sacks (TOHP 1) 1994;Selvais 1995;Sirtori 1998;Thien 1993;Veale 1994; von Schacky 1999.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

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Omega 3 fatty acids for prevention and treatment of cardiovascular disease

Hooper

2004

Cochrane Database of Systematic Reviews

191

143

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Background It has been suggested that omega 3 (W3, n-3 or omega-3) fats from oily fish and plants are beneficial to health. Objectives To assess whether dietary or supplemental omega 3 fatty acids alter total mortality, cardiovascular events or cancers using both RCT and cohort studies. Search methods Five databases including CENTRAL, MEDLINE and EMBASE were searched to February 2002. No language restrictions were applied. Bibliographies were checked and authors contacted. Selection criteria RCTs were included where omega 3 intake or advice was randomly allocated and unconfounded, and study duration was at least six months. Cohorts were included where a cohort was followed up for at least six months and omega 3 intake estimated. Data collection and analysis Studies were assessed for inclusion, data extracted and quality assessed independently in duplicate. Random effects meta-analysis was performed separately for RCT and cohort data. Main results Forty eight randomised controlled trials (36,913 participants) and 41 cohort analyses were included. Pooled trial results did not show a reduction in the risk of total mortality or combined cardiovascular events in those taking additional omega 3 fats (with significant statistical heterogeneity). Sensitivity analysis, retaining only studies at low risk of bias, reduced heterogeneity and again suggested no significant effect of omega 3 fats. Restricting analysis to trials increasing fish-based omega 3 fats, or those increasing short chain omega 3s, did not suggest significant effects on mortality or cardiovascular events in either group. Subgroup analysis by dietary advice or supplementation, baseline risk of CVD or omega 3 dose suggested no clear effects of these factors on primary outcomes. Neither RCTs nor cohorts suggested increased relative risk of cancers with higher omega 3 intake but estimates were imprecise so a clinically important effect could not be excluded. Authors’ conclusions It is not clear that dietary or supplemental omega 3 fats alter total mortality, combined cardiovascular events or cancers in people with, or at high risk of, cardiovascular disease or in the general population. There is no evidence we should advise people to stop taking rich sources of omega 3 fats, but further high quality trials are needed to confirm suggestions of a protective effect of omega 3 fats on cardiovascular health. There is no clear evidence that omega 3 fats differ in effectiveness according to fish or plant sources, dietary or supplemental sources, dose or presence of placebo.

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Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

Lee¹,

Lip²

2003

Arch Intern Med

215

158

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The pathophysiology of atherothrombosis in cardiovascular disease is complex and multifactorial. No doubt, lifestyle habits such as exercise, smoking, diet, and alcohol consumption may have significant influence on cardiovascular disease. As the hemostatic system is assuming an increasingly prominent role in the pathogenesis and progression of atherovascular diseases, this review evaluates the effects of lifestyle habits (or lifestyle modifications) on blood coagulation, fibrinolysis, and platelet reactivity.

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Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy

Abstract: Increased transcapillary escape rate of albumin and activity could not be modified during diet supplementation with fish oil in insulin-dependent diabetic patients with nephropathy.

Cited by 21 publications

References 16 publications

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation

Omega 3 fatty acids for prevention and treatment of cardiovascular disease

Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity

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