Lack of Effect of Fetal Administration of Cocaine on Maternal and Fetal Plasma Adrenocorticotropin, Cortisol and Lactate Concentrations at 127–138 Days Gestational Age
Abstract:Few in vivo studies have been done to characterize the effects of cocaine on the maternal and fetal pituitary-adrenal axis during pregnancy. We, therefore, administered cocaine (2 mg·kg–1) intravenously to 6 fetal sheep at 127–138 days of gestation. There was a transient reduction in fetal arterial pO2 with a concomitant increase in pCO2 and a prolonged fall in pH (p < 0.05) following cocaine injection. No changes were seen in maternal pCO2 PCO2 or pH. Mat… Show more
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