Lack of effect of bumetanide on body potassium content in hypertension.

Murchison, L E; Bewsher, PD

doi:10.1111/j.1365-2125.1975.tb01691.x

Cited by 8 publications

(2 citation statements)

References 13 publications

(15 reference statements)

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“…Several reports (Singh & Watt, 1976;Kubik et al, 1977;Murchison et al, 1975) with Burinex K and one (Lewis, 1979) with Diumide K show that plasma potassium is maintained over periods of up to six months, and by inference suggest that the dose of potassium included in the tablet is effective in long term treatment. This is supported by the findings of the present short term study.…”

Section: Discussionmentioning

confidence: 99%

A study of two diuretic/potassium combinations in heart failure

Hussain

Walton

Davidson

et al. 1985

Postgraduate Medical Journal

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Summary:The effect of potassium supplements was studied in 28 patients taking long term frusemide (40-80 mg daily). Plasma potassium fell when supplements were stopped, and rose towards prior values on the potassium/frusemide combination, Diumide K. In a crossover study in 14 of these patients comparing equivalent doses offrusemide, Diumide K (frusemide 40 mg, potassium 8 mmol), bumetanide, and Burinex K (bumetanide 0.5 mg, potassium 7.7 mmol) plasma potassium was lower on frusemide than on bumetanide. On Diumide K and Burinex K plasma potassium rose significantly but did not reach the levels on prior therapy. Small doses of potassium in combined formulations seem to be effective in countering the mild hypokalaemia caused by loop diuretics.

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Section: Discussionmentioning

confidence: 99%

A study of two diuretic/potassium combinations in heart failure

Hussain

Walton

Davidson

et al. 1985

Postgraduate Medical Journal

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“…Furosemide [19], Hypertension e.g. Bumetanide [20] Analgesic and anti-inflammatory e.g. Sodium salicylate [21], antiallergic drug Tranilast [22] Antibacterial and antiseptic e.g.…”

Section: Benzoic Acid: General Introductionmentioning

confidence: 99%

Benzoic Acid and It’s Synthetic Derivatives as Important Medicinal Product Attenuates Cancer: an Up-to-date Review

Kumar,

YT,

Singh

et al. 2023

Preprint

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Cancer is a catchall term that refers to a collection of more than one chronic disease that can adversely affect the body, including the organs of the body. These diseases can be grouped together under the umbrella term "cancer." Cancer is a catch-all term that is used to refer to a number of different diseases. During the process of looking for new chemical entities, it was found that certain compounds with a basic nucleus of benzoic acid (BA) exhibit a remarkable anticancer potential. This was discovered while the researchers were looking for new chemical entities. In the sixteenth century, the aromatic chemical known as BA, which is also known as an aromatic carboxylic acid, was discovered. BA is also referred to as an aromatic carboxylic acid. When it comes to the chemical synthesis of a wide range of different active molecules, the utilization of a sizeable quantity of BA as a raw material is absolutely necessary. In addition to being present in a variety of other naturally occurring compounds, the BA moiety is the component that is responsible for the activity of the naturally occurring compounds vanillin, gallic acid, and syringic acid. In the synthesis of a wide variety of synthetic bioactive molecules, the BA scaffold is utilized as a building block. The drugs furosemide, bumetanide, benzocaine, tetracaine, and bexarotene are all examples of molecules that fall into this category. The scope of this review article allows for the discussion of a number of noteworthy and recent achievements of BA derivatives in terms of their effectiveness against cancer.

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A Decade of Developments in Diuretic Drug Therapy

Martinez

1986

The Journal of Clinical Pharma

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New diuretics introduced into clinical medicine during the past decade include potent new loop diuretics such as bumetanide and piretanide, the uricosuric indanyloxyacetic acid derivative indacrinone, and a new generation of sulfamoyl diuretics such as indapamide and xipamide, which are recommended primarily for the treatment of hypertension. Pharmacokinetic studies of individual diuretics have demonstrated that the diuretic and natriuretic responses to the newer agents generally follow the plasma drug concentration-time curves and urinary drug excretion rates. Therapeutic monitoring can therefore be achieved in most patients with edema or hypertension by close clinical observation and laboratory analysis of plasma electrolyte and creatinine concentrations and urinary electrolyte excretion rates. Interest in the mechanisms involved in the renal and extrarenal vascular actions of the newer diuretics has led to a better understanding of how changes in venous compliance, peripheral vascular resistance, and renal blood flow distribution may contribute to the overall therapeutic response to these agents, especially in patients with severe congestive heart failure, renal insufficiency with low glomerular filtration rates, and hypertension with cardiorenal complications. Adverse reactions to modern diuretics, which are mainly an extension of their renal pharmacodynamic effects, have proved to be minimal, provided that the dosage is adjusted to meet but not exceed individual patient requirements. However, the long-term consequences of prolonged periods of diuretic-induced alterations in plasma potassium levels, and metabolic effects that include elevated blood lipids, are still under investigation.

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Lack of effect of bumetanide on body potassium content in hypertension.

Cited by 8 publications

References 13 publications

A study of two diuretic/potassium combinations in heart failure

A study of two diuretic/potassium combinations in heart failure

Benzoic Acid and It’s Synthetic Derivatives as Important Medicinal Product Attenuates Cancer: an Up-to-date Review

A Decade of Developments in Diuretic Drug Therapy

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