Lack of effect of atenolol and nadolol on the metabolism of theophylline.

Abstract

The effects of 7 days of pretreatment with atenolol, 150 mg day-1, or nadolol, 80 mg day-', on the pharmacokinetics and metabolism of theophylline were determined in six male smokers. Theophylline clearance, volume of distribution, half-life and the urinary excretion of theophylline and its metabolites were unchanged during either treatment compared with control.