Lack of effect of anxiety on total plasma MHPG in depressed patients

Karege, Félicien; Bovier, Patrick A.; Hilleret, Henriette; Gaillard, Jean‐Michel

doi:10.1016/0165-0327(93)90107-u

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Fluvoxamine was found to improve anxiety and hypochondriasis more effectively than sulpiride did, and also to decrease pMHPG levels; thus, anxiety and hypochondriasis might be related to hyperactivity of noradrenergic neurons. In contrast, Karege et al reported finding no correlation between the druginduced decrease in pMHPG and the degree of anxiety, albeit without considering the potential effect of anxiety on pMHPG levels in depressed patients [17]. Sheline et al found that fluvoxamine-and fluoxetine-treated patients did not differ in clinical outcome or in CSF concentrations of MHPG levels before or after treatment [35].…”

Section: Discussionmentioning

confidence: 97%

Plasma Levels of Catecholamine Metabolites Predict the Response to Sulpiride or Fluvoxamine in Major Depression

Ueda¹,

Yoshimura²,

Shinkai³

et al. 2002

Pharmacopsychiatry

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We investigated the relationships between the changes in plasma catecholamine metabolites obtained from depressed patients before and after administration of sulpiride, a benzamide compound, or fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), and between clinical responses to treatment with each of these drugs. Responders to sulpiride had significantly lower plasma homovanillic acid (pHVA) levels before administration of sulpiride than did non-responders or controls (responders: 4.5 +/- 3.1 ng/ml, non-responders: 11.1 +/- 5.9 ng/ml, controls: 10.9 +/- 5.3 ng/ml). Positive relationships were observed between changes in pHVA levels and improvement rates in the 17-item Hamilton Depression Rating Scale (Ham-D). In contrast, responders to fluvoxamine had significantly higher plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) levels before administration of fluvoxamine than did non-responders or controls (responders: 8.5 +/- 1.8 ng/ml, non-responders: 5.9 +/- 2.I ng/ml, controls: 5.2 +/- 2.9 ng/ml). Negative relationships were observed between changes in pMHPG levels and improvement rates in Ham-D. These results suggest that lower pretreatment pHVA levels and higher pretreatment levels of pMHPG might be predictors of response to sulpiride and fluvoxamine, respectively, and that sulpiride might produce a functional increase in the dopaminergic system, resulting in improvement in some depressive symptoms; fluvoxamine, on the other hand, might produce a functional decrease in the noradrenergic system via serotonergic neurons, resulting in improvement of those symptoms.

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Section: Discussionmentioning

confidence: 97%

Plasma Levels of Catecholamine Metabolites Predict the Response to Sulpiride or Fluvoxamine in Major Depression

Ueda¹,

Yoshimura²,

Shinkai³

et al. 2002

Pharmacopsychiatry

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“…The presence of symptoms related to anxiety may thus predict a favorable clinical response in depressed patients treated with drugs that enhance serotonergic transmission. This may help the outcome prediction for serotonergic antidepressant, which is often difficult to make due to the low reliability of the common biological markers, such as low CSF or plasma 5-HIAA levels, platelet MAO activity, 3H-imiprarnine binding, abnormal dexamethasone suppression test or total plasma MHPG levels in anxious and nonanxious depressed patients [35].…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Amitriptyline and Amineptine in Patients Affected by Anxious Depression

Rampello

Nicoletti²,

Raffaele

et al. 1995

Neuropsychobiology

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In a double-blind, placebo-controlled study, the therapeutic efficacy of two antidepressants with different neurochemical mechanisms of action, amitriptyline and amineptine, was investigated in patients affected by anxious depression. Sixty-six patients with the primary dignosis of major depression or bipolar affective disorder (DSM-III-R) and meeting additional operational clinical criteria such as anxiety, trepidation, restlessness, early and/or late insomnia, impulsivity, hostility, dysphoria, compulsivity, hyperperspiration, palpitation, pollakiuria and phobias were included. They were randomly assigned to three groups (n = 22) and treated either with placebo, amitriptyline (up to 100 mg/day) or amineptine (up to 200 mg/day) for 6 weeks. Patients showed better response to amitriptyline, a preferential inhibitor of serotonin reuptake, than to amineptine, a selective inhibitor of dopamine reuptake. The present results suggest that alterations in serotonergic rather than dopaminergic transmission contribute to the pathophysiology of anxious depression.

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“…Depression is also frequently associated with dementia and is a mental health major issue in the elderly. Low plasma and urinary levels of MHPG have been found in some patients with depression 12–15 . Thus, MHPG levels in biological fluids may reflect certain aspects of the mental condition.…”

mentioning

confidence: 99%

Relationship between saliva level of 3‐methoxy‐4‐hydroxyphenylglycol and mental health in the elderly general population

Li¹,

Watanabe²,

Kunitake³

et al. 2008

Psychiatry Clin Neurosci

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Aims: A large number of studies on the monoamine systems in Alzheimer's disease (AD) have found abnormalities of the noradrenergic system in the brain, but there has been no report concerning the relationship between noradrenergic activity and cognitive function in elderly living in a community. The aim of the present study was to explore the relationship between saliva level of 3-methoxy-4-hydroxyphenylglycol (sMHPG) and mental health in this population. Methods:The study was to examine the relationship between sMHPG and performance on the MiniMental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck Depression Inventory (BDI) in 213 elderly people living in the local community.Results: sMHPG in female subjects was positively correlated with age (r = 0.24, P = 0.003) and negatively correlated with scores on the MMSE (r = -0.26, P = 0.0016) and FAB (r = -0.19, P = 0.024), even after controlling for the effect of age (MMSE r = -0.20, P = 0.013). Notably, sMHPG was correlated with the pentagon drawing score (P = 0.0008) of MMSE. sMHPG was significantly correlated with BDI score in male subjects, but negatively correlated in female subjects. A gender difference was found in the relationship between the sMHPG and BDI score. Conclusion:The measurement of sMHPG may be a useful marker of mental health in elderly community-dwelling subjects.

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Lack of effect of anxiety on total plasma MHPG in depressed patients

Cited by 5 publications

References 18 publications

Plasma Levels of Catecholamine Metabolites Predict the Response to Sulpiride or Fluvoxamine in Major Depression

Plasma Levels of Catecholamine Metabolites Predict the Response to Sulpiride or Fluvoxamine in Major Depression

Comparative Effects of Amitriptyline and Amineptine in Patients Affected by Anxious Depression

Relationship between saliva level of 3‐methoxy‐4‐hydroxyphenylglycol and mental health in the elderly general population

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