Lack of effect following repeated in vivo exposure of the rabbit urinary bladder to urine from interstitial cystitis patients at low infusion volumes

Kohn, Ira J.; Filer‐Maerten, Sharon; Whitmore, Kristene; Hanno, Philip M.; Ruggieri, Michael R.

doi:10.1002/(sici)1520-6777(1998)17:2<147::aid-nau8>3.0.co;2-d

Cited by 8 publications

(1 citation statement)

References 13 publications

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“…Instillation of urine from IC patients into the bladder of rabbits resulted in histological inflammatory changes that resembled human IC bladders, but did not yield statistically significant differences in 24-hour urinary frequency and volume (26). Intravesical instillation of acetone solutions induced transient IC in rats, monkeys, and rabbits that included markedly increased voiding frequency and decreased volume per void (27)(28)(29).…”

Section: Intravesical Irritant Instillation Modelsmentioning

confidence: 96%

Animal Models for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)

İzgi¹,

Daneshgari²

2013

Erciyes Med J

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Animal Models For Interstitial Cystitis/Painful Bladder Syndrome The International Continence Society has defined IC/PBS as "the complaint of suprapubic pain related to bladder filling, accompanied by other symptoms such as increased daytime and night-time frequency, in the absence of proven urinary infection or other obvious pathology" (1). IC is a chronic inflammation of the urinary bladder in the absence of verified infection (2, 3), and presents with the symptoms of frequent and urgent urination along with pain or irritation in the bladder and lower urinary tract (LUT), necessitating the addition of the new terminology painful bladder syndrome (PBS) (3-5). Complete diagnostic criteria for epidemiological studies of IC/PBS have not been established. Earlier diagnostic criteria proposed by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDKK) included a cystoscopic finding of glomerulations upon bladder distension or Hunner's ulcer, in addition to bladder pain or urinary urgency, along with several criteria to exclude other diseases (6). However, 10% to 34% of patients with urinary urgency due to bladder pain do not exhibit glomerulations upon bladder distension and only 10% of patients diagnosed with IC present with Hunner's ulcer (7-10). Depending on the diagnostic criteria used, the prevalence of IC/PBS has been estimated as between 0.03% to 2.0% of adults (11-13). The prevalence of IC/PBS among women is estimated to be 2 to 5 times higher than in men (3, 13). The recent Rand Epidemiology study of IC/PBS in women in the United States identified the prevalence of IC/ PBS as 6.5% and 2.7% based on high sensitivity and high specificity diagnostic criteria, respectively, which translates to 3.3 to 7.9 million women suffering from IC/PBS symptoms (14). According to the NIDDK diagnostic criteria, IC/PBS occurs 17 times more frequently in relatives of IC/PBS patients than in the general population in the United States (15). The medical costs have been estimated at more than $100 million per year in the United States (16).

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