Lack of direct role of parkin in the steady-state level and aggregation of α-synuclein and the clearance of pre-formed aggregates

Kim, Yoon Suk; Patel, Smita S.; Lee, Seung-Jae

doi:10.1016/j.expneurol.2005.10.024

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Parkin Gene Expression1

Cell Culture and Viral Infection With Parkin-expressing Aden1

Introduction1

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Cited by 6 publications

(3 citation statements)

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“…A recombinant adenoviral vector containing the parkin gene (parkin virus) was produced as previously described [24]. Cells were plated in 6-well plates (2 Â 10 5 per well) and 24 h later cells were infected with different concentrations of either parkin virus or a mock virus diluted in serum-free DMEM.…”

Section: Parkin Gene Expressionmentioning

confidence: 99%

Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells

Lee

Cho

Jung

et al. 2015

Biochemical and Biophysical Research Communications

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Section: Parkin Gene Expressionmentioning

confidence: 99%

Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells

Lee

Cho

Jung

et al. 2015

Biochemical and Biophysical Research Communications

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“…HeLa (human cervical adenocarcinoma cells, ATCC) cells were infected with adenoviruses as described previously (34).…”

Section: Cell Culture and Viral Infection With Parkin-expressing Adenmentioning

confidence: 99%

Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cells

Lee¹,

Lee²,

Kang³

et al. 2012

BMB Reports

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“…We suggest that Pakrin is a useful marker for evaluating conditions of cells after UVB irradiation. Kim et al (Kim et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet B (UVB) Induces Down-regulation of Parkin Gene Expression

Kim

Kang

Lee³

et al. 2016

BSL

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Ultraviolet (UV) irradiation induces cellular damage. A variety of cellular responses for repairing cellular damage including DNA damage occur after UV irradiation. During the repair processes, expression and activation of various molecules are regulated depending on the types of cellular damage. Parkin is an E3 ligase and act as a tumor suppressor. Recently, it has been reported that Parkin is involved in the DNA repair process. In the current study, we investigated whether UVB irradiation influences expression of Parkin. Parkin expression transiently decreased after UVB irradiation both at the mRNA and protein levels, but returned to normal levels thereafter. Taken together with cell viability data, Parkin expression is down-regulated during UVB-induced suppression of cell growth and is increased again in accordance with recovery of UVB-induced cell growth inhibition. However, Parkin overexpression or knockdown did not influence UVB-induced cell growth inhibition and recovery. We propose that Parkin could be a useful molecular marker for evaluating conditions of cells after UVB irradiation.

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Lack of direct role of parkin in the steady-state level and aggregation of α-synuclein and the clearance of pre-formed aggregates

Cited by 6 publications

References 13 publications

Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells

Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells

Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cells

Ultraviolet B (UVB) Induces Down-regulation of Parkin Gene Expression

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