Lack of Direct Effects of Neurotrophic Factors in an In Vitro Model of Neuroinflammation
Nimra Aziz,
Chiara Ruzza,
Chiara Falcicchia
et al.
Abstract:Neuroinflammation is associated with several neurological disorders including temporal lobe epilepsy. Seizures themselves can induce neuroinflammation. In an in vivo model of epilepsy, the supplementation of brain-derived neurotropic factor (BDNF) and fibroblast growth factor-2 (FGF-2) using a Herpes-based vector reduced epileptogenesis-associated neuroinflammation. The aim of this study was to test whether the attenuation of the neuroinflammation obtained in vivo with BDNF and FGF-2 was direct or secondary to… Show more
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