Lack of cytotoxic activity against <i>Mycobacterium leprae</i> 65-kD heat shock protein (hsp) in multibacillary leprosy patients

Barrera, Silvia de la; Fink, S.; Finiasz, Marta; Minnucci, F.; Valdez, Raúl; Baliña, Luis; Sasiain, María C.

doi:10.1111/j.1365-2249.1995.tb03477.x

Cited by 13 publications

(3 citation statements)

References 47 publications

(22 reference statements)

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“…Here we observed that MDR-and S-TB patients failed to induce degranulation of CD8 ϩ cells and to evoke a CTL response, likely due to the high Th2 profile induced in CD4 ϩ and CD8 ϩ cells from these patients. In line with this, a gradual loss of CD8-mediated CTL activity against autologous H37Rv-pulsed macrophages dependent on IL-10 production has been observed in patients with active S-TB (10-12), and modulation of Mycobacterium leprae Hsp65-induced CTL activity by IL-10 and IL-4 has also been observed in leprosy patients (11). In addition, IL-4 leads to development of a CD8 ϩ T-cell subset that fails to upregulate granzyme B, a potent apoptosis-inducing protease of CTLs (44).…”

Section: Discussionsupporting

confidence: 56%

Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-ResistantMycobacterium tuberculosisM and Ra Strains

et al. 2009

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Section: Discussionsupporting

confidence: 56%

Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-ResistantMycobacterium tuberculosisM and Ra Strains

et al. 2009

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“…In previous studies, we, as well as others [10–12], have shown that whole M. leprae and M. leprae recombinant proteins were able to induce cytotoxic activity of T lymphocytes from patients with leprosy and from BCG‐vaccinated individuals against autologous macrophages that present M. leprae antigens. It is well known that cytokines can regulate most aspects of immune function.…”

Section: Introductionmentioning

confidence: 73%

IL-9 promotes anti-Mycobacterium lepraecytotoxicity: involvement of IFNγ

Finiasz

Franco

Barrera

et al. 2006

Clinical and Experimental Immunology

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SummaryInterleukin 9 (IL-9) is a T-cell derived factor preferentially expressed by CD4+ Th2 cells and it has been characterized both in human and murine systems. It is a pleiotropic cytokine with multiple functions on cells of the lymphoid, myeloid and mast cell lineages, as well as on lung epithelial cells. Other activities described for IL-9 support its contribution to asthma and its important role in helminthic infections, where a Th2 response can be protective and IL-9 enhances resistance or is responsible for elimination of the nematode. Nevertheless, until recently there were no studies on its role in bacterial infections in man. We have demonstrated that cytokines can modulate the specific cytotoxicity generation in peripheral blood mononuclear cells from leprosy patients and normal controls. In the present report we studied the effect of IL-9 in this experimental model. Our results indicate that IL-9 can counteract the negative effect mediated by IL-4 on the generation of M. leprae-induced cytotoxic T lymphocytes. Moreover, it can increase this lytic activity in controls and enhance the stimulatory effect of IL-2 or IL-6 in cells from leprosy patients and controls. IL-9 is also able to revert the inhibitory effect of IL-10 and IL-13 on the M. leprae-induced cytotoxic activity. Although the exact mechanism of action of IL-9 remains to be determined, interferon gamma seems to be required for the effect of IL-9 in this experimental model. These data suggest that IL-9 may have an atypical Th2 behaviour and play a role in the modulation of the immune response to mycobacterial infections.

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“…The bacterial Hsps might modulate immunity by rapidly and directly increasing cytokine production in macrophages. T cells reacting to Hsp65 appear to play an important role in the control of M. leprae infection (de la Barrera et al, 1995). Hsp65 directly activates monocytes during mycobacterial infection.…”

Section: Hsps As Antigens In M Tuberculosismentioning

confidence: 99%

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

Cardona¹

2012

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Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients

Cited by 13 publications

References 47 publications

Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-ResistantMycobacterium tuberculosisM and Ra Strains

Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-ResistantMycobacterium tuberculosisM and Ra Strains

IL-9 promotes anti-Mycobacterium lepraecytotoxicity: involvement of IFNγ

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

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