Lack of cross-reactivity between 5-aminosalicylic acid-based drugs: a case report and review of the literature

Safety of 5-Aminosalicylic Acid Derivatives in Patients with Sensitivity to Acetylsalicylic Acid and Nonsteroidal Anti-inflammatory Drugs

“…All of the articles found in the literature search were case reports, [7][8][9][10] and the nature and validity of the ASA or NSAID sensitivity were not verified in any of these cases. In addition, the decision to initiate a 5-ASA desensitization protocol pre-emptively may have ameliorated any reaction to 5-ASA.…”

“…The literature regarding the safety of 5-ASA derivatives in patients with sensitivity to ASA or NSAID is scant; the successful use of 5-ASA derivatives in ASA-or NSAID-sensitive patients has been reported, and the report of a patient tolerating ASA but not 5-ASA 10 suggests that cross-reactivity between these 2 classes of medications is unlikely. However, these reports are limited by the lack of information regarding the validity of prior reactions to ASA or NSAID in the patients described.…”