Lack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission

Parekh, Bharat; Shaffer, Nathan; Cp, Pau; Abrams, Elaine J.; Pa, Thomas; Pollack, Henry; Bamji, Mahrukh; Kaul, Aditya; Schochetman, Gerald; Rogers, M.

doi:10.1097/00002030-199110000-00004

Cited by 75 publications

(24 citation statements)

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“…Although the trend for a higher reactivity to C53 MN in 1-h supernatants was observed in nontransmitting mothers, these results provide evidence that presence of HIV V3 loop-specific antibody in the mothers does not correlate with lower vertical transmission. This finding is consistent with recent reports indicating that HIV V3-specific antibody in mothers did not reveal a correlation with prevention from HIV infection in their offsprings (14,(16)(17)(18)(19). Additionally, in the present study, humoral immunity to HIV infection in mothers as evaluated by de novo antibody synthesis was also not related with vcrtical transmission, since the levels were equivalent in transmitting and nontransmitting mothers.…”

Section: Table 4 Anti-v3 Loop Cytophilic Antibodies Of Maternal Origsupporting

confidence: 93%

Correlation of Maternal Cytophilic Human Immunodeficiency Virus (HIV)-1 V3 Loop Peptide-Specific Antibodies in Infants with Vertical HIV Transmission

1995

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Approximately 70% of human immunodeficiency virus (H1V)-1-infected pregnant women do not transmit HIV to their offsprings. The identification of factors involved in maternalchild transmission of HIV is important for the design and implementation of therapeutic and prevention strategies. Recently we have developed a modified peripheral mononuclear cell (PBMC) culture system for in vitro antibody production (IVAP) by which we can distinguish serum-derived cytophilic anti-HIV-1 antibody from de novo synthesized antibody. In this study, we analyzed the presence of antibodies directed to HIV-1 gp160, gp120, gp41, and V3 loop synthetic peptides (C51, C53, and C57 from MN and IIIB strains) utilizing the grid-blot method in PBMC cultures of 52 mother-child pairs. Among the mothers (39 nontransmitters and 13 transmitters), presence of serum-derived cytophilic antibodies or de novo synthesized HIV V3 loop peptide-specific antibodies did not correlate with vertical transmission. However, PBMC-associated, cytophilic antibodies of maternal origin reactive with C51, C53, and C57 from MN and IIIB strains were identified in cultures of uninfected infants, but not in infected infants. These observations suggest that cytophilic antibodies of maternal origin directed to HIV-1 V3 loop peptides which are

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Section: Table 4 Anti-v3 Loop Cytophilic Antibodies Of Maternal Origsupporting

confidence: 93%

Correlation of Maternal Cytophilic Human Immunodeficiency Virus (HIV)-1 V3 Loop Peptide-Specific Antibodies in Infants with Vertical HIV Transmission

1995

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“…Because passive maternal antibody is the primary immunity that a fetus acquires, it is likely that maternal humoral immunity is one factor in vertical transmission of HIV-1 (12)(13)(14)(15). However, the specificities of maternal antibodies that can protect against HIV-1 transmission are unclear (16)(17)(18)(19)(20). It is also likely that factors related to maternal virus titers, virus July 1993. tropism for different cell types, and virus variability contribute to vertical transmission.…”

Section: Introductionmentioning

confidence: 99%

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

Lamers¹,

Sleasman²,

She³

et al. 1994

J. Clin. Invest.

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The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env VI and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual. (J. Clin. Invest. 1994. 93:380-390.) Key words: human immunodeficiency virus 1 genetic variation * maternal transmission

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“…Antibodies specific for peptides in the envelope glycoprotein gp41 have also been reported to be associated to protection against VT (Ugen et al 1997). However, other studies have found no association with antibody specificity or titer and mother-to-child HIV-1 transmission (Parekh et al 1991, Robertson et al 1992, Halsey et al 1992, Khouri et al 1995, Louisirirotchanakul et al 1999. Nevertheless, it must be remembered that HIV-1 specific humoral immune response during pregnancy is known to be reduced (Mikyas et al 1997, Bongertz et al 1998.…”

Section: Humoral Immune Responsementioning

confidence: 99%

“…However, there appears to be no major discussion on the finding that broadly neutralizing antibodies present in high titers will be associated to non-transmission of HIV-1 (Sienna Workshop 1992, Scarlatti et al 1993b, Khouri et al 1995, Hutto et al 1996, Jansson et al 1997, Cologognesi et al 1997, Bongertz et al 1999, Louisirotchanakul et al 1999. Nevertheless, some studies do not detect any protection by neutralizing antibodies in VT (Parekh et al 1991, Kliks et al 1994, Hengel et al 1998, Mabondzo et al 1998. A recent study carried out in monkeys indicated that low titer neutralizing antibodies do not protect at all; only partial protection is achieved, even by antibodies able to neutralize up to 90% of HIV-1 infection at low dilutions; and that, in order to be protective, specific neutralization has to be absolute, neutralizing 100% of the present virus (reviewed by Moore & Burton 1999).…”

Section: Humoral Immune Responsementioning

confidence: 99%

Vertical human immunodeficiency virus type 1 - HIV-1 -transmission - a review

Bongertz¹

2001

Mem. Inst. Oswaldo Cruz

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Lack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission

Cited by 75 publications

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Correlation of Maternal Cytophilic Human Immunodeficiency Virus (HIV)-1 V3 Loop Peptide-Specific Antibodies in Infants with Vertical HIV Transmission

Correlation of Maternal Cytophilic Human Immunodeficiency Virus (HIV)-1 V3 Loop Peptide-Specific Antibodies in Infants with Vertical HIV Transmission

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

Vertical human immunodeficiency virus type 1 - HIV-1 -transmission - a review

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