Lack of Correlation between Hypothalamic Serotonin and the Ether-Induced ACTH Secretion in Adrenalectomized Rats

Kárteszi, M.; Palkóvits, M.; Kiss, János; Kanyicska, B.; Stark, E.

doi:10.1159/000123121

Cited by 15 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and concomitant decrease in plasma GH observed within 5 15 min after exposure to ether vapors in the present study agree with previous reports demonstrating stress-induced alterations in the levels of ACTH [12,32], PRL [19], |5-F.nd [7,18], and GH [32], They also provide new evidence indi cating selective and differential changes in monoamine me tabolism in stressed animals within the various discrete brain areas.…”

Section: Discussionsupporting

confidence: 93%

Effect of Acute Ether Stress on Monoamine Metabolism in Median Eminence and Discrete Hypothalamic Nuclei of the Rat Brain and on Anterior Pituitary Hormone Secretion

1985

View full text Add to dashboard Cite

This study was designed to correlate the endocrine responses elicited by acute ether stress with the changes in metabolism of several monoamines in discrete nuclei of the rat brain. Concentrations of norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) and also of the specific metabolites of NE, DA, and 5-HT, 3-methoxy-4-hydroxyphenylethylene glycol, 3,4-dihydroxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, respectively, were concurrently measured in microdissected nuclei using high-performance liquid chromatography with electrochemical detection. The ratio of the metabolites to their respective amines was used as an estimate of the metabolism of NE, DA, and 5-HT. Acute exposure to ether vapors induced, within 5–15 min, large increments in plasma levels of adrenocorticotropic hormone (ACTH), β-endorphin, and prolactin (PRL), and decrements in the levels of plasma growth hormone (GH). Significant increases in NE metabolism were observed in the rostral (AN_r) and caudal (AN_C) divisions of the arcuate nucleus, as well as in the paraventricular (PVN) and dorsomedial nuclei, 15 min after ether stress. A significant decrease in 5-HT metabolism was observed in the PVN, supraoptic nucleus, and AN_C, whereas significant increases in 5-HT metabolism were detected in the suprachiasmatic nucleus and AN_r. DA metabolism selectively increased in the AN_r. The present results indicate that the acute changes in ACTH, β-endorphin, PRL, and GH release induced by ether exposure are temporally correlated with (1) increases in NE metabolism in many hypothalamic nuclei; (2) a selective increase in DA metabolism restricted to the AN_r, and (3) differential effects on 5-HT metabolism, probably reflecting selective activation or inhibition of different populations of 5-HT neurons.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of Acute Ether Stress on Monoamine Metabolism in Median Eminence and Discrete Hypothalamic Nuclei of the Rat Brain and on Anterior Pituitary Hormone Secretion

1985

View full text Add to dashboard Cite

show abstract

“…Other lesion studies by Szafarczyk et al [45] indicate that 5-HT terminals outside the SCN are also involved in generating the diurnal rhythm in ACTH release. Ganong [16], however, finding no effect of injecting low doses of L-tryptophan on plasma corticosteroids in the'dog, suggests that 5-HT systems may not affect ACTH release, and others have reached a similar conclusion [23,25,36]. On the other hand, Fuller [ 13] and Fuller el al.…”

Section: Discussionmentioning

confidence: 98%

Diurnal Variation in Hypothalamic Monoamines and Plasma Corticosterone in the Turkey after Inhibition of Tyrosine Hydroxylase or Tryptophan Hydroxylase

1982

View full text Add to dashboard Cite

Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA treatment also abolishes the diurnal rhythm in plasma corticosterone and elevates the basal levels of this steroid suggesting that 5-HT terminals in the hypothalamus may inhibit the release of ACTH at certain times of the day and in this fashion generate diurnal fluctuations in plasma corticosterone. Hypothalamic levels of dopamine (DA) and norepinephrine (NE) also vary diurnally, and synthesis inhibition with alpha-methyl-para-tyrosine abolishes the diurnal rhythm in NE but not DA or in plasma corticosterone. Temporal changes in release and/or degradation of DA are significant factors contributing to the diurnal rhythms of this amine in the hypothalamus. Diurnal fluctuations in plasma corticosterone do not depend on recent synthesis of catecholamines.

show abstract

“…Several experiments have failed to find a supporting role for 5-HT in pituitary adrenal control (Dixit and Buckley, 1969;Berger et al, 1974;Pavel et al, 1977;Karteszi et al, 1981), but many pharmacological studies have found a stimulatory role for 5-HT in ACTH regulation.…”

mentioning

confidence: 99%

“…Jones et al (1976) demonstrated that 5-HT stimulated CRF release from rat hypothalami in in vitro experiments, but few studies (Karteszi et al, 1981) have examined the effects of these compounds on CRF activity in the hypothalamus employing in vivo methods.…”

mentioning

confidence: 99%

The effect of serotonin agonist 1-(trifluoromethylphenly)-piperazine on corticotropin releasing factor and arginine vasopressin in rat hypothalamic nuclei.

et al. 1982

View full text Add to dashboard Cite

Effects of 1-(m-trifluoromethylphenyl)-piperazine, a serotonin agonist, were examined on rat plasma levels of adrenocorticotropin (ACTH) and arginine vasopressin (AVP), and on hypothalamic contents of corticotropin releasing factor (CRF) and AVP, to investigate the role of brain serotonin in ACTH regulation.Both plasma ACTH and AVP levels increased markedly 30 min after injection of the compound and were still elevated at 80 min. CRF and AVP contents in the median eminence decreased 30 min after injection but returned to the basal levels by 80 min. The AVP content in the supraoptic nucleus was elevated 80 min after injection.The CRF and AVP content did not significantly change in the paraventricular, suprachiasmatic and arcuate nuclei. Serotonin or 1-(m-trifluoromethylphenyl)-piperazine did not stimulate the release of ACTH in pituitary cell cultures. These results suggest that both CRF and AVP were secreted into the portal vessels by 1-(mtrifluoromethylphenyl)-piperazine to release ACTH from the anterior pituitary and that both the ACTH and AVP release were stimulated via the brain serotonergic mechanism.

show abstract

Lack of Correlation between Hypothalamic Serotonin and the Ether-Induced ACTH Secretion in Adrenalectomized Rats

Cited by 15 publications

References 22 publications

Effect of Acute Ether Stress on Monoamine Metabolism in Median Eminence and Discrete Hypothalamic Nuclei of the Rat Brain and on Anterior Pituitary Hormone Secretion

Effect of Acute Ether Stress on Monoamine Metabolism in Median Eminence and Discrete Hypothalamic Nuclei of the Rat Brain and on Anterior Pituitary Hormone Secretion

Diurnal Variation in Hypothalamic Monoamines and Plasma Corticosterone in the Turkey after Inhibition of Tyrosine Hydroxylase or Tryptophan Hydroxylase

The effect of serotonin agonist 1-(trifluoromethylphenly)-piperazine on corticotropin releasing factor and arginine vasopressin in rat hypothalamic nuclei.

Contact Info

Product

Resources

About