Lack of correlation between HLA-B35 resistance against herpes labialis and antibody titers to HSV-1

Gallina, Giuseppe; Cumbo, Vincenzo; Messina, Pietro; Caprera, Vita; Lio, Domenico; Caruso, Calogero

doi:10.1016/0030-4220(89)90187-4

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…Regarding the cross-talk between nuclear receptors, the present study is consistent with the previous literature regarding CAR-mediated suppression of HNF4α (Gallina et al, 1989) (Figure 12). The CAR-mediated suppression of HNF4α may lead to a decrease in glucose and lipid metabolism pathways.…”

Section: Discussionsupporting

confidence: 92%

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

Cui

Klaassen

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are well-known xenobiotic-sensing nuclear receptors with overlapping functions. However, there lacks a quantitative characterization to distinguish between the PXR and CAR target genes and signaling pathways in liver. The present study performed a transcriptomic comparison of the PXR- and CAR-targets using RNA-Seq in livers of adult wild-type mice that were treated with the prototypical PXR ligand PCN (200 mg/kg, i.p. once daily for 4 days in corn oil) or the prototypical CAR ligand TCPOBOP (3 mg/kg, i.p., once daily for 4 days in corn oil). At the given doses, TCPOBOP differentially regulated many more genes (2125) than PCN (212), and 147 of the same genes were differentially regulated by both chemicals. As expected, the top pathways differentially regulated by both PCN and TCPOBOP were involved in xenobiotic metabolism, and they also up-regulated genes involved in retinoid metabolism, but down-regulated genes involved in inflammation and iron homeostasis. Regarding unique pathways, PXR activation appeared to overlap with the aryl hydrocarbon receptor signaling, whereas CAR activation appeared to overlap with the farnesoid X receptor signaling, acute-phase response, and mitochondrial dysfunction. The mRNAs of differentially regulated drug-processing genes (DPGs) partitioned into three patterns, namely TCPOBOP-induced, PCN-induced, as well as TCPOBOP-suppressed gene clusters. The cumulative mRNAs of the differentially regulated drug-processing genes (DPGs), phase-I and –II enzymes, as well as efflux transporters were all up-regulated by both PCN and TCPOBOPOP, whereas the cumulative mRNAs of the uptake transporters were down-regulated only by TCPOBOP. The absolute mRNA abundance in control and receptor-activated conditions was examined in each DPG category to predict the contribution of specific DPG genes in the PXR/CAR-mediated pharmacokinetic responses. The preferable differential regulation by TCPOBOP in the entire hepatic transcriptome correlated with a marked change in the expression of many DNA and histone epigenetic modifiers. In conclusion, the present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands. Results from this study will further support the role of these receptors in regulating the homeostasis of xenobiotic and intermediary metabolism in liver, and aid in distinguishing between PXR and CAR signaling at various physiological and pathophysiological conditions.

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Section: Discussionsupporting

confidence: 92%

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

Cui

Klaassen

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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“…Similar associations were reported for Italian HIV-infected intravenous drug ilddicts (23), chronic active hepatitis in Latin American Caucasoid patients (24) and children with juvenile rheumatic arthritis-uveitis (25,26). However, the presence of HLA-B35 was associated with decreased frequency of recurrent circumoral herpetic lesions (27,28). Some of these results need to be confirmed in different ethnic backgrounds; for example, there was a lack of association for chronic active hepatitis in a Dutch population (29).…”

Section: Discussionsupporting

confidence: 65%

The relative distribution of B35 alleles and their IEF isotypes in a HLA‐B35‐positive population

1995

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The HLA-B35 serotype represents a group of antigens detectable by IEF, cytotoxic T cells, and by sequencing analysis. Four isotypes and eight alleles have been thus far reported. We have determined the relative frequencies of these B35 subtypes in a group of 203 unrelated people. Dot blot hybridization of PCR amplified products was performed using 23 sequence-specific oligo probes designed based on the EMBL HLA class I sequence database. The amplification was achieved by a pair of group-specific primers, producing approximately 600 bp fragments. By hybridization pattern analysis, we found that four alleles represent over 95% of the B35+ population, with relative frequency of 48.2% for B*3501, 23.7% for B*3502, 15.2% for B*3503, and 8.0% for B*3508. We also identified 3 individuals with B*3504 and one with B*3505, and seven samples with new patterns. B*3501 and B*3503 exactly correlated with the most common isotype B35.3, B*3502 and B*3504 with B35.2, B*3508 may be the B35.1 IEF isotype. The B*3505 was identified from an individual with B35 IEF variant form. Our study shows that the B35 antigen has a wide distribution of alleles, and that many more B35-related alleles may yet to be uncovered.

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“…Based on the fact that HSV-1 enters, replicates, spreads, and establishes latent infections with virtually identical efficiencies in C57BL/6 and BALB/c mice, individuals of the species Mus musculus do not appear to differ fundamentally in their innate resistance to HSV-1 infection. Likewise, although it has been implied that differences in host resistance are relevant in explaining what differentiates humans with recurrent herpetic disease from the vast majority of asymptomatic carriers of HSV-1 and HSV-2 (15,29,31,33), there is little epidemiological evidence to support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1

Halford

Balliet

Gebhardt

2004

J Virol

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It is often stated that individuals of a species can differ significantly in their innate resistance to infection with herpes simplex virus type 1 (HSV-1). Three decades ago Lopez reported that C57BL/6 mice could survive a 5,000-fold-higher inoculum of HSV-1 given intraperitoneally than mice of the A or BALB/c strain (Nature 258:152-153, 1975). Susceptible strains of mice died of encephalitis-like symptoms, suggesting that viral spread to the central nervous system was the cause of death. Although Lopez's study documented that C57BL/6 mice were resistant to the development of HSV-1 encephalitis and mortality, the resistance of C57BL/6 mice to other steps of the HSV-1 infection process was not assessed. The results of the present study extend these observations to clarify the difference between resistance to (i) HSV-1 pathogenesis, (ii) HSV-1 replication, (iii) HSV-1 spread, and (iv) the establishment of latent HSV-1 infection. Although C57BL/6 mice are more resistant to HSV-1 pathogenesis than BALB/c mice, the results of the present study establish that HSV-1 enters, replicates, spreads, and establishes latent infections with virtually identical efficiencies in C57BL/6 and BALB/c mice. These observations raise questions about the validity of the inference that differences in natural resistance are relevant in explaining what differentiates humans with recurrent herpetic disease from the vast majority of asymptomatic carriers of HSV-1 and HSV-2.

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Lack of correlation between HLA-B35 resistance against herpes labialis and antibody titers to HSV-1

Cited by 9 publications

References 16 publications

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

The relative distribution of B35 alleles and their IEF isotypes in a HLA‐B35‐positive population

Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1

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