Abstract:Multiple sclerosis is a chronic demyelinating disease of the human central nervous system (CNS) of a still unknown etiology. CCL5 is localized in white matter tracts undergoing demyelination, suggesting that this chemokine participates in the pathogenesis of disease by attracting inflammatory cells into the CNS. The CCL5 -28C/G functional polymorphism have been reported to be associated with multiple sclerosis, however, evidence remains conflicting. In the current study, we investigated distibution of the CCL5… Show more
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