Lack of Cognitive Impairment in First-Degree Relatives of Children with Pervasive Developmental Disorders

Szatmári, Péter; Jones, Marshall B.; Tuff, Larry; Bartolucci, Giampiero; Fisman, Sandra; Mahoney, William J.

doi:10.1097/00004583-199311000-00022

Cited by 94 publications

(107 citation statements)

References 27 publications

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“…The incidence of autism in the general population is 0.2%, but the risk of having a second (or additional) autistic child increases almost 50-fold to approximately 10 to 20%. [31][32][33][34] What tools are available with appropriate psychometric properties to specifically screen for autism? Appropriately sensitive and specific autism screening tools for infants and toddlers have only recently been developed, and this continues to be the current focus of many research centers.…”

Section: Neurology 2000;55:468-479mentioning

confidence: 99%

Practice parameter: Screening and diagnosis of autism

Filipek¹,

Accardo²,

Ashwal³

et al. 2000

Neurology

824

414

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Article abstract-Autism is a common disorder of childhood, affecting 1 in 500 children. Yet, it often remains unrecognized and undiagnosed until or after late preschool age because appropriate tools for routine developmental screening and screening specifically for autism have not been available. Early identification of children with autism and intensive, early intervention during the toddler and preschool years improves outcome for most young children with autism. This practice parameter reviews the available empirical evidence and gives specific recommendations for the identification of children with autism. This approach requires a dual process: 1) routine developmental surveillance and screening specifically for autism to be performed on all children to first identify those at risk for any type of atypical development, and to identify those specifically at risk for autism; and 2) to diagnose and evaluate autism, to differentiate autism from other developmental disorders.This statement has been endorsed

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Section: Neurology 2000;55:468-479mentioning

confidence: 99%

Practice parameter: Screening and diagnosis of autism

Filipek¹,

Accardo²,

Ashwal³

et al. 2000

Neurology

824

414

View full text Add to dashboard Cite

show abstract

“…Findings regarding communication impairments in parents of autistic children have been somewhat equivocal. In several studies with a direct assessment of verbal capacities no significant differences between parents of autistic children and parents of children with Down syndrome were obtained (Leboyer, Plumet, Goldblum, Perez-Diaz, & Marchaland, 1995;Szatmari et al, 1993). Some studies have hinted at the presence of restricted and stereotyped behaviors in parents of autistic children.…”

Section: Introductionmentioning

confidence: 99%

Broader Autism Phenotype in Parents of Autistic Children: Reality or Myth?

Scheeren

Stauder

2007

J Autism Dev Disord

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The finding that relatives of individuals with autism show mild autistic traits is referred to as the broader autism phenotype (BAP). In the current study, 25 parents with a child with high-functioning autism and 25 parents with typically developed children were compared on: (1) the Block Design Test, (2) the Autism-Spectrum Quotient (AQ), and (3) a reaction time task to examine reflexive covert visual orienting to social (eyes) and non-social (arrows) cues. The parent groups were scored similar on the Block Design Test and the AQ. However, fathers with an autistic child demonstrated a different reaction time pattern and responded slower on the social cues than control fathers. These results partly support and further elaborate on the BAP in parents with an autistic child.

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“…A subsequent study by Freeman et al (8), directly testing the relatives of autistic probands and comparing data on them to published norms, failed to detect higher rates of cognitive disorders in the autism relatives. Similarly, Szatmari et al (9) reported no differences on direct testing in a comparison of the relatives of probands with pervasive developmental disorder and the relatives of Down syndrome probands. More recently, Szatmari et al (10) used the family history method and also failed to find a higher rate of cognitive deficits in relatives of probands with pervasive developmental disorder.…”

mentioning

confidence: 98%