Lack of Clinically Significant In Vitro and In Vivo Interactions between Ranitidine and Sucralfate

Mullersman, Gotelind; Gotz, Vincent P.; Russell, Wayne L.; Derendorf, Hartmut

doi:10.1002/jps.2600751018

Cited by 18 publications

(3 citation statements)

References 18 publications

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“…However, these explanations are not definitive yet, or rather controversial. Particularly, several different reasons were proposed for the cases of ranitidine (17,(21)(22)(23) and cimetidine (18)(19)(20)24). Since most drugs are mainly absorbed from the small intestine, but not from the stomach, gastric emptying is the rate-limiting step for drug absorption, particularly for drugs with high permeability and high solubility as classified in BCS class I (25).…”

Section: Introductionmentioning

confidence: 99%

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

et al. 2007

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“…Reversing the order will not prevent an interaction, as sucralfate remains in the stomach for many hours after administration. Sucralfate can be given concomitantly with H 2 blockers without affecting their overall absorption; 39,40 therefore, no separation of dosing times is necessary.…”

Section: Jfms Clinical Practicementioning

confidence: 99%

Acute Vomiting in Cats

Trepanier

2010

Journal of Feline Medicine and Surgery

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“…Double or multiple peaks in the concentration-time profile and/or variations in the invasion profile have been reported for a series of drugs including acetaminophen (15), cimetidine (16), ranitidine (17), furosemide (18), flurbiprofen (19), pafenolol (20), veralapride (21), ciclotropium (22), etacrynic acid (23), ibuprofen (24), tranylcypromine (25), and celiprolol (26). However, in only a few cases the available data could provide an explanation.…”

Section: Introductionmentioning

confidence: 99%

Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs

Lipka

Lee

Langguth

et al. 1995

Journal of Pharmacokinetics and Biopharmaceutics

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Investigation of the underlying mechanism leading to inter- and intrasubject variations in the plasma concentration-time profiles of drugs (1) can considerably benefit rational drug therapy. The significant effect of gastric emptying on the rate and extent of celiprolol absorption and its role with respect to double-peak formation was demonstrated in the present study. In four dogs racemic celiprolol was dosed perorally in a crossover design during four different phases of the fasted-state gastric cycle and gastric motility was recorded simultaneously using a manometric measurement system. Intravenous doses were also given to obtain disposition and bioavailability parameters. The blood samples were assayed by a stereoselective HPLC method (2). The time to onset of the active phase of the gastric cycle showed an excellent correlation with the time to celiprolol peak concentration. Furthermore, bioavailability was increased when celiprolol was administered during the active phase. Double peaks were observed when the first active phase was relatively short, suggesting that a portion of the drug remained in the stomach until the next active phase. Population pharmacokinetic modeling of the data with a two-compartment open model with two lag times incorporating the motility data confirmed the effect of time to gastric emptying on the variability of the oral pharmacokinetics of celiprolol. The fasted-state motility phases determine the rate and extent of celiprolol absorption and influence the occurrence of double peaks. Peak plasma levels of celiprolol exhibit less variability if lag times, and therefore gastric emptying times, are taken into consideration.

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Lack of Clinically Significant In Vitro and In Vivo Interactions between Ranitidine and Sucralfate

Cited by 18 publications

References 18 publications

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

Acute Vomiting in Cats

Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs

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