Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis

Ponzoni, Maurilio; Arrigoni, Gianluigi; Gould, Victor E.; Curto, Barbara Del; Maggioni, Marco; Scapinello, Antonio; Paolino, Salvatore; Cassisa, Angelo; Patriarca, Carlo

doi:10.1016/s0046-8177(00)80223-3

Cited by 265 publications

(168 citation statements)

References 28 publications

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“…It typically affects middle-aged to older adults who have acute to subacute onset of symptoms related to vascular obstruction in a wide variety of extranodal sites, often accompanied by fever. [26][27][28] The protean nature of the symptoms and the lack of discrete lesions often lead to a delay in diagnosis; as was true of our patient, the diagnosis is sometimes not established until autopsy. Histologic features were similar to those of other cases of intravascular large B-cell lymphoma, and it was the absence of CD20 that was unusual and prompted further immunophenotyping that disclosed the presence of HHV8.…”

Section: Discussionmentioning

confidence: 88%

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

et al. 2009

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Section: Discussionmentioning

confidence: 88%

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

et al. 2009

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“…However, the international consensus meeting of intravascular large B-cell lymphoma (IVLBCL) proposed a new definition of IVLBCL, which included cases from both western and Asian countries [39]. They added the criterion of a concomitant minimal extravascular location of the neoplastic cells [40] to the WHO criteria, which states that the neoplastic lymphocytes might only be present in the lumina of the small vessels, such as capillaries [41]. DLBCLRP produced interstitial infiltration as well as intrasinusoidal lymphomatous infiltration in the BM, liver, and LN ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

et al. 2008

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We evaluated six cases of diffuse large B-cell lymphoma (DLBCL) involving the red pulp of the spleen. All had B symptoms and an aggressive clinical course. The lymphoma cells proliferated diffusely and non-cohesively in the cords of the red pulp. The lymphoma involved the bone marrow in four of the five patients and the liver in all four of the patients examined. However, lymph node (LN) involvement was rare at presentation, and systemic LN involvement was not observed even in the terminal phase. The lymphoma cells infiltrated the intrasinusoidal/intravascular and interstitial spaces of the involved tissues and were detected in the peripheral blood in two of the six patients. CD5-expressing lymphoma cells were detected in four of the five patients examined. Because these cases had some unique clinical features and occurred in distinct splenic sites, we proposed that primary splenic DLBCL manifesting in red pulp is a distinct clinicopathological entity.

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“…18 This unusual distribution of lymphoma cells leads to protean clinical features secondary to small vessel occlusion including nephrotic syndrome, mental status changes, and shortness of breath. 19,20 Hematologic abnormalities, including autoimmune hemolytic anemia, have also been associated with this diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases

2005

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Two unusual cases of large B-cell lymphoma with predominant splenic and bone marrow (BM) involvement and similar clinical and histopathologic features are described. Both patients presented with nonspecific constitutional symptoms, unexplained cytopenias, and splenomegaly. Splenectomy revealed diffuse red pulp involvement by large B-cell lymphoma. The perisplenic lymph nodes were also involved diffusely with effacement of normal nodal architecture, excluding a diagnosis of intravascular large B-cell lymphoma. BM biopsies revealed striking erythroid hyperplasia without overt morphologic evidence of involvement by lymphoma. Immunoperoxidase staining of the marrow biopsies with antibodies to CD20 and erythroidassociated antigens revealed involvement by large B-cell lymphoma morphologically resembling the early pronormoblasts. In both cases there was prominent, but not exclusive, intravascular/intrasinusoidal lymphomatous marrow infiltration. These cases represent an unusual variant of large B-cell lymphoma with distinctive patterns of splenic and BM involvement. Furthermore, they underscore the difficulties in identifying intrasinusoidal marrow infiltration by lymphoma in H&E-stained biopsy slides and demonstrate that this pattern of marrow infiltration may be seen in cases of large B-cell lymphoma distinct from the intravascular variant. Keywords: diffuse large B-cell lymphoma; intravascular lymphoma; spleen; bone marrow; erythroid hyperplasia; non-Hodgkin lymphoma Diffuse large B-cell lymphoma (LBCL) can involve nodal or extranodal sites; however, initial presentation in the spleen occurs infrequently. 1 Typically when diffuse LBCL involves the spleen it forms discrete tumoral masses within the splenic parenchyma. 2 A recent report detailed other less common patterns of splenic involvement by LBCL including diffuse infiltration of the splenic red pulp. 3 The clinicopathologic features of diffuse LBCL with these unusual patterns of splenic involvement have yet to be fully elucidated. Described herein are the distinctive clinical and histopathologic features of two cases of splenic LBCL with diffuse red pulp infiltration and concurrent involvement of lymph nodes and bone marrow (BM). These cases had strikingly similar clinical presentations chiefly characterized by dyspnea, unexplained cytopenias, and splenomegaly. In both instances, splenectomy performed to alleviate the cytopenias revealed diffuse, homogeneous involvement of the splenic red pulp by diffuse LBCL. Although the pattern of splenic red pulp involvement and the clinical features raised the possibility of intravascular LBCL, in both cases there was parenchymal involvement of splenic hilar lymph nodes, excluding this diagnosis as defined by the most recent WHO criteria. 4 Furthermore, both cases had prominent BM involvement by lymphoma, which was difficult to detect by routine morphologic evaluation of hematoxylin and eosin (H&E)-stained biopsy slides. This difficulty was due both to the presence of prominent erythroid hyperplasia as well as a predominan...

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Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis

Cited by 265 publications

References 28 publications

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases

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