Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli
Paula Berbegal-Sáez,
Ines Gallego-Landin,
Javier Macía
et al.
Abstract:Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand behavioural and motivational implications. By employing a new mathematical analysis based on entropy divergence, we identified disrupted intricate activity patterns in mice derived by the complete absence of BMAL1 and quantified the difference regarding the activity oscillation’s complexity.… Show more
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