Lack of benefit from semi‐annual screening for cancer of the lung: Follow‐up report of a randomized controlled trial on a population of high‐risk males in czechoslovakia

Kubík, A; Parkin, D. Maxwell; Khlat, Myriam; Erban, JK; Polák, J; Adamec, Miloslav

doi:10.1002/ijc.2910450107

Cited by 233 publications

(119 citation statements)

References 11 publications

(6 reference statements)

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“…In order to diagnose lung cancer at a pre-symptomatic stage, four randomized controlled trials on lung cancer screening were conducted in high-risk populations (male cigarette smokers) (12)(13)(14)(15)(16). None of the trials succeeded in demonstrating a reduction in overall mortality.…”

Section: Discussionmentioning

confidence: 99%

Impact of Delay on Diagnosis and Treatment of Primary Lung Cancer

Jensen¹,

Mainz²,

Overgaard³

2002

Acta Oncologica

107

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Section: Discussionmentioning

confidence: 99%

Impact of Delay on Diagnosis and Treatment of Primary Lung Cancer

Jensen¹,

Mainz²,

Overgaard³

2002

Acta Oncologica

107

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“…Three large American screening programmes in the 1970s sponsored by the National Institute of Health [6][7][8][9] and another in Czechoslovakia in the 1980s [10] screened high-risk populations using chest radiography and sputum analysis. All showed increased detection of early-stage lung cancer, more resectable cancers and improved 5-yr survival rates in the screened versus control groups.…”

mentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

121

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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“…[2] Chest X-ray screening was performed in London in the 1960s and in the US and Czechoslovakia in the 1970s. [11][12][13][14] In these screenings, the group at high risk for lung cancer was included as the screening group and the group at low risk for lung cancer was included as the control group. The effects of chest X-rays taken at regular intervals and chest X-rays taken at rare intervals on the mortality were investigated.…”

Section: Discussionmentioning

confidence: 99%

A Cross-sectional Study in Konya; 2,015 Evaluation of Lung Graph

Alkan

Tolu

İnal³

et al. 2017

EJMO

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E pidemiological studies, which are defined as the examination of the incidence of diseases in society and the factors affecting it, are aimed to reveal the incidence and causes of the disease, to eliminate the disease agents, and to manage the resources efficiently and correctly. [1] Posteroanterior (PA) chest radiograph, one of the earliest practical methods used to detect thoracic pathologies, is used in imaging the trachea, mediastinum, the heart, the diaphragm, subdiaphragmatic areas, hilus, pulmonary vasculature, fissures, sinuses, lung parenchyma, pleura, soft Objectives: This study was an evaluation of posteroanterior chest radiographs taken of residents of Konya determined by the cluster sampling method. Methods: This study was a descriptive cross-sectional study, conducted in cooperation with the Konya Education and Research Hospital, the provincial health directorate, and the metropolitan municipality. The sociodemographic characteristics of 2015 individuals participating in the study were recorded. The standard chest radiographs, which were taken with a traditional analog system during inspiration in the standing position, were evaluated by 2 radiologists. The most obvious pathological finding was recorded. Results: Of the participants, 1075 (53.40%) were female and 940 (46.60%) were male. The mean age was 45.89±0.45 years for the women and 46.20±0.54 years for the men. In the group, 340 (16.90%) were retired, 492 (24.40%) were farmers and/or laborers, 144 (7.10%) were white-collar employees, and 1039 (51.60%) were housewives or unemployed. In all, 580 (28.80%) were cigarette smokers. While 249 (12.36%) had pathological findings on the chest radiograph, 1766 (87.64%) had normal results. The pathological findings were hilar fullness (n=50, 2.48%), emphysematous appearance (n=48, 2.38%), nodule (n=29, 1.44%), increased reticulonodular density (n=26, 1.29%), increased bronchovascular branching (n=9, 0.44%), bronchiectasis (n=4, 0.20%), and other changes (n=83, 4.12%). The incidence of emphysematous appearance was 2.77 times greater in the smokers than in the non-smokers (p<0.05; odds ratio [OR]: 2.77, confidence interval [CI]: 1.56-4.91). While the chest X-ray was normal in 93.50% of the individuals under the age of 40 years, the rate decreased to 84.60% in the individuals over the age of 40 years. The incidence of a pathological chest radiograph was also 2.62 times higher in individuals over the age of 40 years (p<0.001; OR: 2.62, CI:1.90-3.61). Conclusion:The incidence of pathological lung findings was greater in individuals over the age of 40 years, and in workers and retirees.

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Lack of benefit from semi‐annual screening for cancer of the lung: Follow‐up report of a randomized controlled trial on a population of high‐risk males in czechoslovakia

Cited by 233 publications

References 11 publications

Impact of Delay on Diagnosis and Treatment of Primary Lung Cancer

Impact of Delay on Diagnosis and Treatment of Primary Lung Cancer

Diagnostic imaging of lung cancer

A Cross-sectional Study in Konya; 2,015 Evaluation of Lung Graph

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