Lack of Bcl-2 expression in feline follicular lymphomas

Henrich, Manfred; Bauknecht, Anna; Hecht, Werner; Reinacher, M.

doi:10.1177/1040638719877916

Cited by 4 publications

(8 citation statements)

References 41 publications

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“…The upregulation of this protein in some tumoral cells limits the activation of caspases, prevents cell death, and confers longevity to neoplastic cells [24,28]. This upregulation observed in some human lymphomas has paralleled recent research in veterinary medicine regarding Bcl-2 immunoexpression in feline lymphomas [24][25][26]28]. These studies showed that T-cell lymphomas were more likely to express this Bcl-2 oncoprotein compared with B-cell lymphomas [24][25][26]29,30].…”

Section: Introductionmentioning

confidence: 90%

“…The B-cell lymphoma gene-2 (bcl-2) encodes the Bcl-2 protein-an anti-apoptotic factor that preserves the survival in non-proliferating cells, promoting DNA reparation [24][25][26][27]. The upregulation of this protein in some tumoral cells limits the activation of caspases, prevents cell death, and confers longevity to neoplastic cells [24,28].…”

Section: Introductionmentioning

confidence: 99%

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Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas

Rebollada‐Merino

Porras

Calvo-Ibbitson³

et al. 2022

Veterinary Sciences

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Lymphoma is the most common malignant hematopoietic neoplasm in domestic felines. Twenty-two cases of feline epitheliotropic duodenal T-cell lymphoma were characterized morphologically and immunohistochemically (CD3, Pax5, Ki-67), and Bcl-2 immunoexpression was established. Most cases were in domestic shorthair cats (88.2%), with a mean age of 11.2 years. All lymphomas were CD3+, with a low-to-moderate expression of Ki-67 (< 30%). A correlation between the tumoral pattern of infiltration in the lamina propria and the intraepithelial distribution of the neoplastic lymphocytes was established (p = 0.0155). Intraepithelial nests of neoplastic lymphocytes were predominantly observed in lymphomas with a patchy distribution in the lamina propria, whereas intraepithelial plaques were seen in lymphomas with an obliteration pattern. Bcl-2 was expressed in neoplastic cells in all cases, and a higher expression was associated with increased villous stunting (p = 0.0221), and tended to be present in those cases with increased epithelial damage. The expression of Bcl-2 and the degree of epitheliotropism were correlated with neoplastic progression in epitheliotropic intestinal T-cell lymphomas; those displaying high Bcl-2 immunoexpression showed increased villous stunting and epithelial damage, suggesting that Bcl-2 is overexpressed in advanced tumor stages, and may be used as a predictor of tumoral behavior in feline epitheliotropic intestinal T-cell lymphomas. This entity showed many similarities with human MEITL, so the latter entity should be considered in further lymphoma classifications of domestic animals.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas

Rebollada‐Merino

Porras

Calvo-Ibbitson³

et al. 2022

Veterinary Sciences

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“…BCL-2 was found in one study to be expressed in 11 of 21 feline lymphoma tumors (as opposed to no BCL-2 expression in SCC tumors), and expression of the gene was higher in T-cells than B-cells [44]. However, another study showed lack of BCL-2 expression in follicular lymphomas [45]. Because the BCL-2 family of genes regulates apoptosis, with BCL-2 (along with BCL-XL and BCL-W) acting as an apoptosis inhibitor through inhibition of cytochrome C and AIF release, which would then activate caspases leading to apoptosis [46], dysregulated BCL-2 may lead to extended cell survival and resistance to lymphoma therapies seeking to initiate apoptosis [44].…”

Section: Lymphomamentioning

confidence: 97%

Molecular Mechanisms of Feline Cancers

Lin¹,

Kouznetsova²,

Tsigelny³

2020

obm genet

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Feline cancers have not been studied as extensively as canine cancers, though they may offer similar advantages, with cats being immunocompetent animals subject to similar conditions as their human counterparts. The most common feline cancers include lymphoma, squamous cell carcinoma, sarcoma, and mammary tumors, though mast cell tumors were also investigated in this review. As the pathogenesis of many feline cancers remains unclear, this study seeks to elucidate some molecular mechanisms behind feline cancers. Feline lymphoma has been commonly associated with feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV), though in recent years it has appeared more as lymphoma of the gastrointestinal tract. Chromosomal alterations (translocations) due to the virus-associated lymphoma, as well as aberrant gene expression (such as in COX-2 and MDR1) have been identified in the past. While feline lymphoma may be divided into many subtypes, feline sarcoma may be divided into two broad classifications of feline injection site associated (FISS) sarcoma and spontaneous sarcoma, with FISS being a potential model for inflammation leading to tumorigenesis in humans. Previous studies have found multiple chromosomal alterations (including aneuploidy and chromosomal translocations), as well as aberrations in gene expression in feline sarcoma. In the past, oral squamous cell carcinoma has been proposed as a model for human head and neck cancer, and mammary tumors have been proposed as a model for human breast cancers due to similar prognosis and phenotype, as well as higher rate of occurrence in cats than in humans. Mutations have been identified in genes such as TP53, ERBB2, and TWIST1 in feline mammary tumors. c-KIT mutations were commonly located in feline mast cell tumors, though these findings were not particularly significant in terms of correlation to other prognostic indicators. This review seeks to elucidate pathways and treatments for feline cancers for the field of comparative genomics and oncology.

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“…Once the balance breaks, it may lead to various neurodegenerative diseases with a fundamental pathological feature of cell death, such as strokes with a high number of neurons dying by necrosis (Tian et al, 2019;Zhou et al, 2020). Some researchers have Karamitopoulou et al, 2007;Farnebo et al, 2011;Omori et al, 2011;Sen et al, 2015;Heng et al, 2016;Bani-Ahmad et al, 2018;Chen et al, 2019;Henrich et al, 2019;Moledina et al, 2019;Schiffmann et al, 2019 Prognostic Bcl-2, Bax, p53, Fas, FasL, caspase-2, caspase-3, caspase-7, caspase-8, caspase-9, TNF-α, DNA fragmentation, Bak, Bok, Bim, PUMA, PMAIP1, MCL1, BCL2L10, TRAIL, TRAIL-R1/2/3, c-FLIP, IAPs Feng et al, 2018;Huang K.H. et al, 2018 Necroptosis Diagnostic NLRP3, AUNIP, RIPK1/3 He et al, 2016;Lee et al, 2016;Yang Z. et al, 2019 Prognostic NLRP3, MLKL, RIPK1/3, TLR3/TICAM1, AURKA Yuan et al, 2015;Yao et al, 2017;Conev et al, 2019;Soleymani Fard et al, 2019;Sun et al, 2019;Malhotra et al, 2020 Autophagy Diagnostic LC3, Na+/K+-ATPase, mTOR Mijatovic et al, 2012;Mete et al, 2018;Sui et al, 2018 Prognostic LC3, ATG, BECN1, Na + /K + -ATPase, AMPK, mTOR Cao et al, 2016;Cheng et al, 2016;Schläfli et al, 2016;Gajate et al, 2018;Guo et al, 2019 Ferroptosis Diagnostic GPX4, ALOX15, SLC7A11, BAP1, HSP90, HSPB1, FANCD2, TP53 Kamal et al, 2004;Guerriero et al, 2015;Saif et al, 2016;Hui et al, 2017;…”

Section: Rcds Detection In Clinic Usagementioning

confidence: 99%

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

Lin

et al. 2021

Front. Cell Dev. Biol.

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Over the past few years, the field of regulated cell death continues to expand and novel mechanisms that orchestrate multiple regulated cell death pathways are being unveiled. Meanwhile, researchers are focused on targeting these regulated pathways which are closely associated with various diseases for diagnosis, treatment, and prognosis. However, the complexity of the mechanisms and the difficulties of distinguishing among various regulated types of cell death make it harder to carry out the work and delay its progression. Here, we provide a systematic guideline for the fundamental detection and distinction of the major regulated cell death pathways following morphological, biochemical, and functional perspectives. Moreover, a comprehensive evaluation of different assay methods is critically reviewed, helping researchers to make a reliable selection from among the cell death assays. Also, we highlight the recent events that have demonstrated some novel regulated cell death processes, including newly reported biomarkers (e.g., non-coding RNA, exosomes, and proteins) and detection techniques.

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Lack of Bcl-2 expression in feline follicular lymphomas

Cited by 4 publications

References 41 publications

Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas

Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas

Molecular Mechanisms of Feline Cancers

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

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