“…With the total length of 72 kb, the POR gene is highly polymorphic . The genetic polymorphisms of POR could affect the efficacy of the drugs such as tirapazamine, mitomycin C, cyclophosphamide, midazolam, warfarin, tacrolimus, atorvastatin, clobazam and nifedipine directly or mediated by CYP enzymes . In addition, our study has found that POR rs2868177 could significantly increase CYP2B6 activity as measured by bupropion hydroxylation (data not published).…”