Lack of association of the HSD11B1 gene polymorphisms with obesity and other traits of metabolic syndrome in children and adolescents

A relationship between Single Nucleotide Polymorphism (SNP) in HSD11β1 and ADIPOQ genes and obesity related features in children and adolescents submitted on physical exercises

“…According to the authors, carriers of the two SNPs rs846910 A and rs12086634 T had an increased HSD11β1 expression and activity (GAMBINERI et al, 2011). Furthermore, Fichna et al (2017) did not verify an association between polymorphisms in this gene and features related to MetS (FICHNA et al, 2017). Since distinct results are observed in many studies (TUREK et al, 2014;DEVANG et al, 2017;GAMBINERI et al, 2011;FICHNA et al, 2017) and considering that T allele already was associated to higher expression of HSD11β1 it is possible to consider a possible linkage disequilibrium with another polymorphism in this gene could cause the benefic effect of this allele (MALAVASI et al, 2010).…”

“…Furthermore, Fichna et al (2017) did not verify an association between polymorphisms in this gene and features related to MetS (FICHNA et al, 2017). Since distinct results are observed in many studies (TUREK et al, 2014;DEVANG et al, 2017;GAMBINERI et al, 2011;FICHNA et al, 2017) and considering that T allele already was associated to higher expression of HSD11β1 it is possible to consider a possible linkage disequilibrium with another polymorphism in this gene could cause the benefic effect of this allele (MALAVASI et al, 2010). Lastly and according to our results, the TT genotype appears to contribute for better anthropometric measures.…”

“…It is possible to verify that lipid profile and obesity are influenced by many factors as nutritional behavior, practice of physical exercise and genetics (QI et al, 2005;GOMES FRAGA;BRAGA GOMES, 2014;OGUNDELE et al, 2017;LUIS et al, 2016;TUREK et al, 2014;DEVANG et al, 2017;GAMBINERI et al, 2011;FICHNA et al, 2017;LOPES et al, 2015).…”