Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease

IRGM gene polymorphisms and risk of gastric cancer

“…In a recessive model, carriers of the rs4958847 A allele seem to be protected against gastric cancer development. The frequency of IRGM rs4958847 alleles in our control group (80.77% allele G and 19.23% allele A) is similar to the prevalence in a Spanish cohort (80.4% allele G and 19.6% allele A) 24 …”

Autophagy in Helicobacter pylori Infection and Related Gastric Cancer

“…The exact impact of this coding variation still awaits clarification; however, it has been established that ATG16L1 rs2241880 is located in the N terminus of the WD‐repeat domain in Atg16L1 and therefore may affect protein interactions with other components of the autophagosome. While studies on celiac disease , primary sclerosing cholangitis, and primary biliary cirrhosis have failed to show an association with ATG16L1 rs2241880, this polymorphism has been widely associated with CD, especially in Caucasian populations . Further, in a recent study, peripheral blood mononuclear cells derived from patients homozygous for the ATG16L1 mutant allele showed increased levels of IL‐1β secretion upon muramyl dipeptide stimulation as compared with cells expressing the wild‐type genotype .…”

Correlation between IRGM genetic polymorphisms and Crohn’s disease risk: a meta-analysis of case-control studies

“…The titles and abstracts of all articles were reviewed and 53 were excluded; full texts and data integrity were then reviewed and another 51 papers were excluded. A total of 11 case-control studies were included in this meta-analysis (Roberts et al, 2008;Amre et al, 2009;Dema et al, 2009;Latiano et al, 2009;Meggyesi et al, 2010;Wolfkamp et al, 2010;Prager et al, 2012;Wang et al, 2012;Zheng and Pang, 2012;Durães et al, 2013;Moon et al, 2013). Publication years of the eligible studies ranged from 2008-2013.…”