Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study

Lorbeer, Roberto; Hetterich, Holger; Strobl, Ralf; Schafnitzel, Anina; Patscheider, H.; Schindler, Andreas; Müller-Peltzer, Katharina; Sommer, Wieland H.; Peters, Annette; Meisinger, Christa; Heier, Margit; Rathmann, Wolfgang; Bamberg, Fabian; Grill, Eva

doi:10.1371/journal.pone.0184858

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Apart from subjective memory loss, in our preliminary study, we found that a substantial proportion of patients with headaches, dizziness had cognitive decline using global cognitive tests. Headache, dizziness and memory loss are the most common unspecific complaints in middle-aged patients of neurology clinics, which have been considered as characteristic of cerebrovascular insufficiency due to CSVD such as WMLs 20 21. In accordance with our preliminary study, it was reported that headache disorders were associated with a 24% greater risk of all-cause dementia 22.…”

Section: Introductionsupporting

confidence: 80%

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Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)—rationale and protocol for a prospective multicentre observational study

et al. 2022

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IntroductionHeadaches, dizziness and memory loss of unspecific causes are the most common non-acute ischemia symptoms in the ageing population, which are often associated with cerebral small vessel disease (CSVD) imaging markers; however, there is insufficient evidence concerning their association with the development of cognitive decline. This study aims to investigate risk factors, clinical course, cerebral and retinal imaging changes, proteomics features of non-symptomatic ischaemia symptomatic patients with cognitive decline.Methods and analysisThe Non-Acute Symptomatic Cerebral Ischemia Registration study is a multicentre, registry-based, prospective observational study, is designed to investigate the cognitive decline in non-acute ischaemia symptomatic patients. We will recruit 500 non-acute ischaemia symptomatic patients from four tertiary hospitals in China. For this study, non-acute ischaemia symptoms will be defined as headaches, dizziness and memory loss. Patients with headaches, dizziness or memory loss over 50 years of age will be included. Clinical features, cognitive assessment, cerebral and retinal imaging data, and a blood sample will be collected after recruitment. Patients will be followed up by structured telephone interviews at 1, 2, 3, 4, 5 years after recruitment. This study will improve our knowledge of the development of cognitive decline in non-acute ischaemia symptomatic patients and factors affecting the cognitive outcomes, which will eventually elucidate underlying pathways and mechanisms of cognitive decline in these patients and facilitate the optimisation of individualised interventions for its prevention and treatment.Ethics and disseminationEthics approval is obtained from The Biomedical Research Ethics Committee of West China Hospital, Sichuan University (Reference No. 2016 (335)). We will present our findings at national and international conferences and peer-reviewed journals in stroke and neurology.Trial registration numberChiCTR-COC-17013056.

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Section: Introductionsupporting

confidence: 80%

“…Among these non-acute ischaemia symptoms, headache, dizziness and memory loss are the most common symptoms accompanied with or without other symptoms in the ageing population. Also, headaches, dizziness and memory loss are all reported to be associated with cerebral ischaemia and cognitive decline 19–22 24 48…”

Section: Discussionmentioning

confidence: 99%

Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)—rationale and protocol for a prospective multicentre observational study

et al. 2022

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“…Consequently, the study population of this MRI substudy, which included the whole cohort, is not representative due to the enrichment of prediabetic and diabetic subjects. However, additional analyses using weights accounting for differences between the MRI substudy and the whole study cohort did not reveal any substantial dissimilarity [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Significant Impact of Coffee Consumption on MR-Based Measures of Cardiac Function in a Population-Based Cohort Study without Manifest Cardiovascular Disease

et al. 2021

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Subclinical effects of coffee consumption (CC) with regard to metabolic, cardiac, and neurological complications were evaluated using a whole-body magnetic resonance imaging (MRI) protocol. A blended approach was used to estimate habitual CC in a population-based study cohort without a history of cardiovascular disease. Associations of CC with MRI markers of gray matter volume, white matter hyperintensities, cerebral microhemorrhages, total and visceral adipose tissue (VAT), hepatic proton density fat fraction, early/late diastolic filling rate, end-diastolic/-systolic and stroke volume, ejection fraction, peak ejection rate, and myocardial mass were evaluated by linear regression. In our analysis with 132 women and 168 men, CC was positively associated with MR-based cardiac function parameters including late diastolic filling rate, stroke volume (p < 0.01 each), and ejection fraction (p < 0.05) when adjusting for age, sex, smoking, hypertension, diabetes, Low-density lipoprotein (LDL), triglycerides, cholesterol, and alcohol consumption. CC was inversely associated with VAT independent of demographic variables and cardiovascular risk factors (p < 0.05), but this association did not remain significant after additional adjustment for alcohol consumption. CC was not significantly associated with potential neurodegeneration. We found a significant positive and independent association between CC and MRI-based systolic and diastolic cardiac function. CC was also inversely associated with VAT but not independent of alcohol consumption.

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“…As the KORA-MRI sub-study focused on individuals without overt cardiocerebrovascular disease 39 , the study sample is not entirely representative of the general population. Participants with prediabetes and diabetes are likely to be over-represented in this cohort which may have favored the selection of diabetes-related variables based on the increased power to detect a diabetes-related effect.…”

Section: Discussionmentioning

confidence: 99%

Machine-learning based exploration of determinants of gray matter volume in the KORA-MRI study

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Rospleszcz

Keeser

et al. 2020

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To identify the most important factors that impact brain volume, while accounting for potential collinearity, we used a data-driven machine-learning approach. Gray Matter Volume (GMV) was derived from magnetic resonance imaging (3T, FLAIR) and adjusted for intracranial volume (ICV). 93 potential determinants of GMV from the categories sociodemographics, anthropometric measurements, cardio-metabolic variables, lifestyle factors, medication, sleep, and nutrition were obtained from 293 participants from a population-based cohort from Southern Germany. Elastic net regression was used to identify the most important determinants of ICV-adjusted GMV. The four variables age (selected in each of the 1000 splits), glomerular filtration rate (794 splits), diabetes (323 splits) and diabetes duration (122 splits) were identified to be most relevant predictors of GMV adjusted for intracranial volume. The elastic net model showed better performance compared to a constant linear regression (mean squared error = 1.10 vs. 1.59, p < 0.001). These findings are relevant for preventive and therapeutic considerations and for neuroimaging studies, as they suggest to take information on metabolic status and renal function into account as potential confounders. A plethora of factors such as cardiovascular, metabolic and lifestyle parameters influence gray matter (GM) volume (GMV) of the human brain, with partially overlapping and intercorrelated and partially differential effects. Among all the potential determinants of GMV, age is probably the best-established factor. There is consensus that a certain decrease of GMV can be considered as a normal function of aging 1,2. As such, it is common practice

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Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study

Cited by 6 publications

References 24 publications

Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)—rationale and protocol for a prospective multicentre observational study

Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)—rationale and protocol for a prospective multicentre observational study

Significant Impact of Coffee Consumption on MR-Based Measures of Cardiac Function in a Population-Based Cohort Study without Manifest Cardiovascular Disease

Machine-learning based exploration of determinants of gray matter volume in the KORA-MRI study

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