Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population

Sharma, Shilpy; Mann, D L; Singh, Tejbir; Ghosh, Balaram

doi:10.1007/s10038-005-0302-4

Cited by 25 publications

(17 citation statements)

References 23 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Szczepankiewicz et al found that the TT genotype for HNMT 314 was more common in Caucasian children with asthma compared to those without the disease (28) . But these findings were not confirmed by other studies that evaluated the same SNP in relation to asthma in German, Japanese, Indian, or Spanish-Caucasian asthma subjects (21, 25-27) . Similarly, we did not identify an association between the variant and asthma among our cohort.…”

Section: Discussioncontrasting

confidence: 72%

Genetic variation within the histamine pathway among patients with asthma – a pilot study

et al. 2014

View full text Add to dashboard Cite

Objective Histamine is an important mediator in the pathophysiology of asthma. We have previously reported that HRH1 is differentially expressed among those with asthma compared to those without asthma. Single histamine related genes have also been associated with asthma. We aimed to evaluate known single nucleotide polymorphisms (SNPs) in genes along the histamine biotransformation and response pathway and determine their association with asthma and HRH1 mRNA expression. Methods We enrolled children and adults (n=93) with/without asthma who met inclusion/exclusion criteria. Genotyping was performed for 9 known SNPs in the HDC, HRH1, HRH4, HNMT, and ABP1 genes. HRH1 mRNA expression was determined on RNA from buccal tissue. General linear model, Fisher's exact test, and Chi-square test were used to determine differences in allele, genotype, and haplotype frequency between subjects with and without asthma and differential HRH1 mRNA expression relative to genotype. Statistical significance was determined by p<0.05. Results No difference was observed in genotype/allele frequency for the 9 SNPs between subjects with and without asthma. The HNMT-1639C/ −464C/ 314C/ 3’UTRA haplotype was more frequently observed in those without asthma than those with asthma (p=0.03). We also observed genetic differences relative to race and gender. HNMT 314 genotype CT was more frequent in males with asthma compared to those without asthma (p=0.04). Conclusions Histamine pathway haplotype was associated with a diagnosis of asthma in our cohort but allele and genotype were not. Subgroup evaluations may also be important. Further studies are needed to determine the potential biological/clinical significance of our findings.

show abstract

Section: Discussioncontrasting

confidence: 72%

Genetic variation within the histamine pathway among patients with asthma – a pilot study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Polymorphisms in the HDC and SLC22A3 genes influenced the risk of both rhinitis and asthma [19]. The association of asthma with HNMT SNP could not be observed in two Caucasian (Spanish and German) and an Indian population [20,21,22]. HNMT gene polymorphism did not influence the endophenotypes of asthma in the German group either [21].…”

Section: Discussionmentioning

confidence: 99%

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor <b><i>HRH4</i></b> Gene

Simon

Semsei²,

Ungvári³

et al. 2012

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Histamine as an inflammatory mediator plays an important role in chronic allergic and asthmatic conditions. However, the role of genetic polymorphisms of the histamine receptor HRH4 (histamine receptor H4) gene in asthma susceptibility and endophenotypes has not been studied yet. Our aim was to investigate the possible association between single nucleotide polymorphisms (SNPs) in the HRH4 gene and asthma or some endophenotypes of asthma. Methods: Twenty-one SNPs of the HRH4 gene were genotyped in 313 asthmatic patients and 360 controls using Sequenom® iPLEX® Gold Genotyping Technology. Results: Genotype distribution of three HRH4 SNPs, namely rs17187619 [p = 0.002; odds ratio, OR (95% confidence interval, CI) = 2.4 (4.1–1.4)], rs527790 [p = 0.0002; OR (95% CI) = 3.3 (6.1–1.8)] and rs487202 [p = 0.00007; OR (95% CI) = 3.5 (6.6–1.9)] differed significantly between patients with or without infection-induced asthma. Haplotypes, which included the rs4800573–rs527790 CC allele combination, were found to be associated with infection-induced asthma [p = 0.0009, OR (95% CI) = 0.5 (0.4–0.8)]. The rs487202–rs574913 CA haplotype was more frequent among patients with infection-induced asthma [p = 0.0006, OR (95% CI) = 1.9 (1.3–2.6)]. None of the SNPs contributed directly to the risk of asthma. Conclusions: Our results suggest that genetic variation in the HRH4 gene might influence the pathogenesis of infection-induced asthma.

show abstract

“…Three other SNPs have also been investigated within the pathway which also result in differences in enzyme function (ABP1 47 C/T, ABP1 995 C/T, and ABP1 4107C/G). Although the functional significance of many identified SNPs within the pathway is unknown, several studies have been conducted to explore potential associations between histamine related genes and asthma and allergic disease which have yielded mixed results (5,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, previous studies have often been conducted among undefined asthma phenotypes and typically only included SNPs within single genes.…”

Section: Introductionmentioning

confidence: 95%

“…Genetic variation has been observed among the genes coding for the proteins responsible for histamine production, response, and degradation (HDC, HRH1, HRH2, HRH3, HRH4, HNMT, ABP1) (5). For example, one singlenucleotide polymorphism (SNP), HNMT314 C/T has been widely investigated in relation to asthma and allergic disease (16)(17)(18)(19)(20)(21). This polymorphism results in an amino acid change (Ala138Val) and decreased enzyme activity (22).…”

Section: Introductionmentioning

confidence: 98%

Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma

Anvari

Vyhlidal

Dai

et al. 2015

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that differences exist among single-nucleotide polymorphisms (SNPs) in genes of the histamine pathway between children with allergic versus nonallergic asthma. Children (7-18 yr of age; n = 202) with asthma were classified as allergic or nonallergic based on allergy skin testing. Genotyping was performed to detect known SNPs (n = 10) among genes (HDC, HNMT, ABP1, HRH1, and HRH4) within the histamine pathway. Chi square tests and Cochran-Armitage Trend were used to identify associations between genetic variants and allergic or nonallergic asthma. Significance was determined by P < 0.05 and false-positive report probability. After correction for race differences in genotype were observed, HRH1-17 TT (6% allergic versus 0% nonallergic; P = 0.04), HNMT-464 TT (41% allergic versus 29% nonallergic; P = 0.04), and HNMT-1639 TT (30% allergic versus 20% nonallergic; P = 0.04) were overrepresented among children with allergic asthma. Genotype differences specifically among the African-American children were also observed: HRH1-17 TT (13% allergic versus 0% nonallergic; P = 0.04) and HNMT-1639 TT (23% allergic versus 3% nonallergic; P = 0.03) genotypes were overrepresented among African-American children with allergic asthma. Our study suggests that genetic variation within the histamine pathway may be associated with an allergic versus nonallergic asthma phenotype. Further studies are needed to determine the functional significance of identified SNPs and their impact on antihistamine response in patients with asthma and allergic disease.

show abstract

Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population

Cited by 25 publications

References 23 publications

Genetic variation within the histamine pathway among patients with asthma – a pilot study

Genetic variation within the histamine pathway among patients with asthma – a pilot study

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor <b><i>HRH4</i></b> Gene

Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma

Contact Info

Product

Resources

About