Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

Rebelo, Ana Cristina Silva; Verlengia, Rozângela; Kunz, Vandeni Clarice; Tamburús, Nayara Yamada; Cerda, Álvaro; Hirata, Rosário Dominguez Crespo; Hirata, Mário Hiroyuki; Silva, Ester da

doi:10.3390/ijms131013691

Cited by 5 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be emphasized that several factors may change the HR in women menstrual cycle. Because of this, all measurements were taken during the follicular phase of the menstrual cycle or in the phase of high hormonal concentration in women who used some type of contraceptive (Rebelo et al 2012), since this is the phase of greater hormonal stability and HRV.…”

Section: Discussionmentioning

confidence: 99%

“…Hemodynamic, autonomic, and glycemic parameters were all measured during either the follicular phase of the menstrual cycle or the phase of high hormonal concentration in women using contraceptive (Rebelo et al. ). The percentage of fat, along with weight, height, glycemic, blood pressure, quality of life (SF‐36) and perceived stress level (PSS‐10) were assessed.…”

Section: Methodsmentioning

confidence: 99%

“…Participants were instructed to avoid moderate or vigorous physical activity, and to refrain from consuming caffeine, chocolate, nicotine, alcohol, and any other stimulating substances for at least 24 h before the evaluation day. Hemodynamic, autonomic, and glycemic parameters were all measured during either the follicular phase of the menstrual cycle or the phase of high hormonal concentration in women using contraceptive (Rebelo et al 2012). The percentage of fat, along with weight, height, glycemic, blood pressure, quality of life (SF-36) and perceived stress level (PSS-10) were assessed.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The impact of sedentarism on heart rate variability (HRV) at rest and in response to mental stress in young women

et al. 2018

View full text Add to dashboard Cite

Sedentarism is one of the main risk factors for the onset of cardiometabolic diseases. Some biomarkers, such as heart rate variability (HRV), have been largely studied and found to be involved in the genesis of the dysfunctions associated with sedentary behavior. However, comparatively few studies have focused on the female sex. The objective of this study was to analyze the hemodynamic, autonomic and quality of life parameters at rest and in response to mental stress of sedentary and physically active young women. A total of 96 women, 18–30 years of age, were divided into sedentary (SW = 48) and active (AW = 48) groups. Anthropometric, hemodynamic and quality of life parameters were evaluated and the R‐R interval was recorded to quantify the cardiac autonomic modulation at rest and in response to the Stroop Color Test. The groups were similar in age, weight, height, body mass index, fat percentage, systolic and diastolic blood pressure values and glycemia. The physical health domain of quality of life was compromised in the SW group. The SW group presented higher heart rate, lower variance of RR interval and RMSSD and higher cardiac sympathovagal balance (LF/HF) both at rest and in response to the mental stress test. We concluded that sedentary lifestyle in women induces impairment in autonomic cardiac modulation at rest and in response to physiological stress, compromising the quality of life, even before altering any cardiovascular or metabolic clinical parameters, reinforcing the potential role of HRV as early marker of cardiovascular risk in this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The impact of sedentarism on heart rate variability (HRV) at rest and in response to mental stress in young women

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In the present study, we found no association of SNPs in the ESR1 gene with MetS; these results coincide with those reported by Goulart et al, where they found no relation of SNPs in ESR1 and ESR2 genes with MetS in Caucasian postmenopausal women ( n = 532) [ 21 ]. However, in the study conducted in young women ( n = 354) by Rebelo et al , they found no association between rs2234693 and rs9340799 SNPs with metabolic variables (total cholesterol, HDL-c, LDL-c, and triglycerides) [ 22 ]. Moreover Gallagher et al reported the association of rs9340799 polymorphism in the ESR1 gene with MetS, and the C allele of rs2234693 with reduced insulin sensitivity in African American families ( n = 548) [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico

Cahua-Pablo

Cruz

Méndez-Palacios

et al. 2015

IJMS

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.

show abstract

“…The amplicons were subjected to electrophoresis on a 10% acrylamide gel and stained with ethidium bromide. Genotyping quality control was performed as described in detail elsewhere [26]. All genotypes were determined by two independent technicians, the results were entered in the database in duplicate, and 10% of the samples were randomly reanalyzed.…”

Section: Methodsmentioning

confidence: 99%

Influence of Beta-2-Adrenergic Receptor Gln27Glu Polymorphism on the Autonomic Heart Rate Modulation in Young Sedentary and Physically Active Women

Silva¹

2015

AJBIO

View full text Add to dashboard Cite

Abstract:Background: Studies have shown an interaction between the autonomic heart rate (HR) modulation and genetic polymorphisms. Nevertheless, it is yet unclear how a particular genetic polymorphism may determine a pattern of autonomic HR control, especially regarding the role of physical exercise. The objective was to investigate the influence of of Beta-2-Adrenergic (β2-AR) Gln27Glu polymorphisms and exercise on HRV of young Brazilian women. Methods: The group was selected as Sedentary Group (SG; n = 88) and physically Active Group (AG; n = 99). The β2-AR polymorphisms were analyzed using PCR-RFLP. The amplicons were subjected to electrophoresis on a 10% acrylamide gel and stained with ethidium bromide. The HR was registered in real time for 15 minutes, in the supine-position. The heart rate variability (HRV) was analysed using Shannon's entropy (SE), conditional entropy (complexity index [CInd] and normalized CInd [NCI]), and symbolic analysis (0V%, 1V%, 2LV%, and 2ULV%). Statistical analysis: Analysis of variance (ANOVA) with Fisher's Least. Results: AG presented higher values for SE and 2ULV%, and lower values for 0V% when compared to SG (p<0.05). There was no significant difference of any index among genotypes both from the complexity and symbolic analysis. The interaction between genotype and exercise did not significantly affect HRV. Conclusion: These results do not support the concept that the β2-AR Gln27Glu polymorphisms affects the HRV indexes in physically active or sedentary women.

show abstract

Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

Cited by 5 publications

References 33 publications

The impact of sedentarism on heart rate variability (HRV) at rest and in response to mental stress in young women

The impact of sedentarism on heart rate variability (HRV) at rest and in response to mental stress in young women

Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico

Influence of Beta-2-Adrenergic Receptor Gln27Glu Polymorphism on the Autonomic Heart Rate Modulation in Young Sedentary and Physically Active Women

Contact Info

Product

Resources

About