Lack of association of ?-aminolevulinic acid dehydratase genotype with cytogenetic damage in lead workers

Abstract

A significant association existed between both SCE and HFC levels and lead exposure. However, different ALAD genotypes were not found to be associated with levels of blood lead and ZPP in the three groups.

Individual susceptibility and genotoxicity in workers exposed to hazardous materials like lead

“…Gene-environment interactions that link exposures, polymorphisms, and disease states are useful in interpreting susceptibility to lead toxicity [7,34,35]. Detection of polymorphisms in such genes can help identification of individuals who may be at increased risk for lead poisoning from environmental or occupational lead exposure.…”

“…Individuals differ in their ability to detoxify and eliminate xenobiotics [7]. Gene-environment interactions that link exposures, polymorphisms, and disease states are useful in interpreting susceptibility to lead toxicity.…”

“…Several in vitro and in vivo studies have investigated the genotoxic effects of lead. While some studies showed an increased chromosomal aberrations (CA) and/or sister chromatid exchange (SCE) frequency in lymphocytes from workers exposed to lead [6,7]; others reported negative results [8].…”

Association Between δ-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism and Blood Lead Levels: A Meta-regression Analysis

“…In contrast, Hu et al (2001) showed that mean blood Pb levels of ALAD1/1 homozygotes were markedly higher than that seen in ALAD 2 carriers. Although in studies of Smith et al (1995), Alexander et al (1998), Hsieh et al (2000, Suzen et al (2003), Wu et al (2004), andBravo et al (2004), means of blood Pb levels of ALAD1/1 homozygotes The study population came from a general population without description of age information, but the age was given a value of "2" because it was conceivable that the mean age of the study should be larger than 20. were quantitatively lower than those of ALAD 2 carriers, the association was not statistically significant.…”

“…A standardization procedure was performed to convert the blood Pb concentration given in micromoles per liter to micrograms per deciliter and the measurement of dispersion to standard deviation (SD). If the study provided stratum information, each stratum of data was entered separately so as to make the best use of the data (Wetmur, 1994;Wu et al, 2004). Thus there was a total of 18 subgroups included in the meta-analysis (Table 1).…”