Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican Mestizo population

Abstract

Major histocompatibility complex (MHC) alleles have been recognized as genetic factors for developing systemic lupus erythematosus (SLE). In the present study we analyzed whether a heat-shock protein gene (HSP70-2) is involved in determining susceptibility to develop SLE in a Mexican Mestizo population. A HSP70-2 Pst I polymorphism was detected by a restriction fragment length polymorphism analysis of polymerase chain reaction (PCR-RFLP) in 107 SLE patients and 158 healthy controls. No statistically significant differences were observed in the HSP70-2 allele distribution between patients and healthy controls. HLA-DR analysis showed an increased frequency of HLA-DR3 allele in the patients group (P Ͻ 0.05, OR = 2.26, EF = 6.0%). On the other hand, when we analyzed HSP70-2 polymorphism in relation to HLA-DR3 allele, we could only detect an increased frequency of AB genotype in the DR3 negative patients (pC Ͻ 0.05, RR = 2.6, EF = 11.3%). Linkage disequilibrium was observed for three haplotypes: HLA-DR3- HSP70

CD154–CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus

“…Interestingly, polymorphisms in heat‐shock protein 70 (6p21.3), another Blimp‐1 target gene 1 (ref. 11, and Shaffer A, et al: unpublished observations), have been observed in SLE patients of African American (25) but not Hispanic descent (26). These results suggest that some of the genetic susceptibility to SLE may relate to an enhanced capacity to generate ISCs, although confirmation of this possibility will have to await identification of specific genes that confer SLE risk.…”

Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus

“…Finally, eleven studies carried out on HLA-DRB1 and -DQB1 polymorphisms in relation to susceptibility to SLE fulfilled inclusion criteria: 1) 9 studies were included in meta-analysis of HLA-DRB1 polymorphism, 2) 6 studies were included in HLA-DQB1 polymorphism analysis and 3) 4 studies were included in haplotype analysis (Table 1). Two of these studies were conducted on Brazilians [7,20], 7 on Mexicans [15][16][17][18][21][22][23], one on Mexican Americans [24] and one on Colombians (current study) (Table 1).…”

Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans

“…23 Minor allele frequencies of many SNPs differ substantially between populations, allowing alleles, when expanded in frequency within one group, more chances to confer greater genetic susceptibility in that one particular population. 24 Examples of ethnic-specific differences in SLE genetic association studies include an association of the p53 gene in Koreans 25 that did not replicate in a Spanish Caucasian population, 26 an association of the heat-shock-protein-encoding gene, HSP70, in Spaniards and Africans but not in Mexicans 27 and the varying levels of significance of CTLA4 associated with SLE in Asians and Europeans. 28 There are even differences in levels of significance within association studies of IRF5 and SLE, such as with studies of Caucasian, 12,14,[17][18][19] Hispanic (Mexican) 15 and Asian subjects.…”