Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis

Zhu, Feng; Qiao, Jie; Qiu, Xusheng; Xu, Leilei; Liu, Zhen; Zhu, Zezhang; Qian, Bangping; Sun, Xu; Qiu, Yong

doi:10.1007/s00586-014-3452-2

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Based on the inclusion and exclusion criteria set initially, out of the initial 690 papers extracted, 126 duplicate papers were removed. After the first inclusion/exclusion process 62 papers were considered for full-text review, from which 43 papers with 19412 cases, 22005 controls and 25 different genes were included in the final analysis14–54 (Figure 1). All excluded studies are presented in Supplemental Table 1 (Supplemental Digital Content 1, http://links.lww.com/BRS/C34).…”

Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis

Almekkawi

Caruso

Ahmadieh

et al. 2023

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Study Design. Meta-analysis. Objective. To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis. Summary and Background Data. Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS. Materials and Methods. Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P <0.05. The final analysis paper’s quality was evaluated using the Newcastle Ottawa Scale. Kappa interrater agreement was calculated to evaluate the agreement between authors. Results. The final analysis comprised 43 publications, 19412 cases, 22005 controls, and 25 distinct genes. LBX1 rs11190870 T>C and MATN-1 SNPs were associated with an increased risk of AIS in one or all of the 5 genetic models. IGF-1, estrogen receptor alfa, and MTNR1B, SNPs were not associated with AIS in all 5 genetic models. Newcastle Ottawa Scale showed good quality for the selected articles. Cohen k = 0.741 and Kappa interrater agreement of 84% showed that the writers were in strong agreement. Conclusions. There seem to be associations between AIS and genetic SNP. Further larger studies should be conducted to validate the results.

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Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis

Almekkawi

Caruso

Ahmadieh

et al. 2023

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“…All the considered studies stated either the affected gene and/or specific single nucleotide polymorphisms (SNPs). Of the 23 studies 15 stated SNPs of the affected gene[ 2 , 8 , 12 , 15 – 26 ], seven of these also presented the risk allele and/or genotype[ 15 , 16 , 18 , 21 , 23 , 25 , 26 ]. Of those that didn’t report the related SNPs, three specified affected gene locus only[ 1 , 7 , 27 ], one stated the specific variant of the affected gene[ 28 ], two specified affected gene locus and deletion or insertion, and/or risk allele[ 4 , 29 ], one stated copy number variant (CNV) of affected gene and corresponding duplication or deletion[ 9 ], and one stated risk allele genotype of the affected gene[ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…In regards to statistical data extracted, 11 studies included only the p-value[ 1 , 2 , 7 , 9 , 18 – 20 , 24 – 26 , 28 ], 11 included both p-value and odds ratio[ 8 , 12 , 15 – 17 , 21 – 23 , 27 , 30 , 31 ], and two provided neither [ 4 , 29 ]. In the case of absent p-value and/or odds ratio the item was not assessed, and the studies were used to identify other possible genes of interest.…”

Section: Resultsmentioning

confidence: 99%

“…Of the selected studies, the following levels of evidence and study designs were included: 10 level III case–control studies[ 2 , 16 , 19 , 20 , 23 – 25 , 27 , 29 , 30 ], seven level III cohort studies[ 1 , 4 , 7 , 8 , 15 , 17 , 21 ], three level III case–control cohort studies[ 9 , 12 , 31 ], three level III case–control association studies[ 18 , 22 , 26 ], one level IV cross-sectional study[ 28 ]. The study characteristics are reported in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review

et al. 2022

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Background Idiopathic Scoliosis (IS) is the most common spinal deformity in adolescents, accounting for 80% of all spinal deformities. However, the etiology remains uncertain in most cases, being identified as Adolescent Idiopathic Scoliosis (AIS). IS treatments range from observation and sport to bracing or surgery. Several risk factors including sex and familiarity, have been linked with IS. Although there are still many uncertainties regarding the cause of this pathology, several studies report a greater incidence of the defect in families in which at least one other first degree relative is affected. This study systematically reviews the available literature to identify the most significant genes or variants related to the development and onset of IS. Methods The research question was formulated using a PIOS approach on the following databases: Medline, Embase, Cinahl, Scopus, Web of Science and Google Scholar. The search was performed from July to August 2021, and articles from the inception of the database to August 2021 were searched. Results 24 of the 919 initially identified studies were included in the present review. The 24 included studies observed a total of 16,316 cases and 81,567 controls. All the considered studies stated either the affected gene and/or specific SNPs. CHD7, SH2B1, ESR, CALM1, LBX1, MATN1, CHL1, FBN1 and FBN2 genes were associated with IS development. Conclusions Although association can be found in some candidate genes the field of research regarding genetic association with the onset of IS still requires more information.

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Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis

et al. 2016

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Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis

Abstract: The SOCS3 gene polymorphisms are not associated with the occurrence of AIS, but the gene polymorphism (rs4969168) is associated with abnormal growth pattern of AIS, indicating that SOCS3 gene might be a disease-modifying gene of AIS.

Cited by 6 publications

References 22 publications

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis

Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review

Association between IGF1 gene single nucleotide polymorphism (rs5742612) and adolescent idiopathic scoliosis: a meta-analysis

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