Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population

Liu, Wenmiao; Qiu, Shiyan; Gao, Chuanping; Wang, Guiju; Liu, Shiguo; Guan, Hongzai

doi:10.1016/j.neulet.2017.08.041

Cited by 1 publication

(1 citation statement)

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“…Family‐based analysis of TDT, HRR, and HHRR showed that CHATrs3793790 was associated with TS, whereas case–control analysis showed the opposite (Yang et al., 2018 ). The candidate genes of SLC5A7 (rs1013940, rs2433718, and rs4676169) were analyzed with the same methods, and the results of the two methods showed that SLC5A7 had no significant association with TS (W. Liu et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

ASH1L may contribute to the risk of Tourette syndrome: Combination of family‐based analysis and case–control study

Liu

Zhang

et al. 2022

Brain and Behavior

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Objective: Tourette syndrome (TS) is a childhood neurodevelopmental disorder caused by various genetic and environmental factors and presents with apparent genetic heterogeneity. As ASH1L potentially contributes to neurodevelopmental diseases, especially in TS, we aim to investigate the susceptibility of ASH1L on TS in the Chinese Han population.Methods: Three tag single nucleotide polymorphisms (SNPs) (rs5005770, rs12734374, and rs35615695) in ASH1L were screened in 271 TS nuclear family trios and 337 healthy subjects by the TaqMan assays real time. A case-control study combined with family-based analysis was applied to study the genetic susceptibility of common variants of ASH1L. Results:The results revealed a significant over-transmission of rs35615695 and rs5005770 (for rs35615695, transmission disequilibrium test, χ 2 = 57.375, p = .000, HHRR, χ 2 = 4.807, p = .028; for rs5005770, HRR, χ 2 = 4.116, p = .042, HHRR, χ 2 = 8.223, p = .004) in family-based study. Furthermore, rs5005770 and rs35615695 still remained significant after Bonferroni correction (p < .017). However, the two SNPs (rs5005770 and rs35615695) were found not to be associated with TS in case-control study. Conclusions:Our study suggests that ASH1L may contribute to TS susceptibility in the Han Chinese population and involved in TS development as a risk factor.

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Section: Discussionmentioning

confidence: 99%