Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk of Prostate Cancer in Finnish Men

Faupel-Badger, Jessica M.; Diaw, Léna; Albanês, Demetrius; Virtamo, Jarmo; Woodson, Karen; Tangrea, Joseph A.

doi:10.1158/1055-9965.epi-07-0672

Cited by 55 publications

(29 citation statements)

References 13 publications

(14 reference statements)

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“…Information on general health and alcohol consumption were self-reported upon study entry, and height and weight were measured. This cross-sectional analysis included 392 subjects from eight previous nested case-control studies of cancer risk that measured pre-randomization serum 25(OH)D. [20][21][22][23][24] Metabolite assessment Serum metabolites were measured by Metabolon Inc. using a non-targeted approach. The assay methods, previously described [25][26][27] utilized a high-resolution, accurate ultra-highperformance liquid-chromatography/mass-spectroscopy and gas-chromatography/mass-spectroscopy platform.…”

Section: Study Populationmentioning

confidence: 99%

“…14,22 One study (46 cases, 21 controls) used the OCTEIA direct enzyme-linked immunosorbent assay kit (IDS, Inc., Boldon, Tyne and Wear, UK). 24 The 25(OH)D represents the sum of vitamins D2 and D3, with most being D3 (vitamin D2 was undetectable in 80% of the subjects). In total, 392 eligible serum samples were measured from pre-randomization fasting serum that was collected and stored at -70 C; there were 255 cases and 137 controls.…”

Section: Serum 25-hydroxyitamin D Determinationmentioning

confidence: 99%

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Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

et al. 2016

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Background: Vitamin D has been discussed in the context of cardiovascular disease, cancer, bone health and other outcomes. Epidemiological studies have reported on the importance of vitamin D in cancer prevention and treatment. The discovery of vitamin D-associated metabolites through agnostic metabolomics analyses offers a new approach for elucidating disease aetiology and health-related pathway identification. Methods: Baseline serum 25-hydroxy-vitamin D [25(OH)D] and 940 serum metabolites were measured in 392 men from eight nested cancer case-control studies in the AlphaTocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers (aged 50-69 years). The metabolomic profiling was conducted using mass spectrometry. We used linear regression to estimate the standardized beta-coefficient as the effect metric for the associations between metabolites and 25(OH)D levels. Results: A majority of the metabolites associated with 25(OH)D were of lipid origin, including 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) [beta-estimate 0.38 per 1 standard deviation (SD) increment], stearoyl-arachidonoyl-glycerophosphoethanolamine (GPPE) (À0.38 per SD) and two essential fatty acids: eicosapentaenoate (EPA; 0.17 per SD) and docosahexaenoate (DHA; 0.13 per SD). Each of these lipid metabolites was associated with 25(OH)D at the principal components corrected P-value of 3.09 Â 10

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Section: Study Populationmentioning

confidence: 99%

Section: Serum 25-hydroxyitamin D Determinationmentioning

confidence: 99%

Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

et al. 2016

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“…However, results from epidemiological studies investigating the association between vitamin D serum levels and prostate cancer risk are largely inconsistent (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). It is possible that the association of serum vitamin D with cancer risk could be modified by common genetic variations in vitamin D-related genes, potentially explaining for some of the inconsistency.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

Ahn¹,

Albanês²,

Berndt³

et al. 2009

Carcinogenesis

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D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tag SNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH) 2 D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tag SNPS in or near the 3# untranslated region (UTR) of VDR, with the strongest association for rs11574143 [odds ratio (95% confidence interval) for risk allele carriers versus wild-type: 2.49 (1.51-4.11), P 5 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3. Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3# UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status.

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“…In a recent review article, the authors conclude that there is no sufficient support for a causal association between high calcium intake and low levels of Vitamin D [15]. This may possibly be a result of differences in maintaining normal levels of serum calcium, but studies of prediagnostic levels of Vitamin D and the risk of prostate cancer, the latter section of the pathway, are also inconclusive [14,[16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Serum calcium and the risk of prostate cancer

Halthur

Johansson

Almquist

et al. 2009

Cancer Causes Control

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Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk of Prostate Cancer in Finnish Men

Cited by 55 publications

References 13 publications

Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

Serum calcium and the risk of prostate cancer

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