Lack of Association between Serum Paraoxonase 1 Activities and Increased Oxidized Low-Density Lipoprotein Levels in Impaired Glucose Tolerance and Newly Diagnosed Diabetes Mellitus

Kopprasch, Steffi; Pietzsch, Jens; Kuhlisch, Eberhard; Graessler, Juergen

doi:10.1210/jc.2002-021561

Cited by 39 publications

(37 citation statements)

References 33 publications

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“…PON and PAF-AH activities have inconstantly been found to be decreased and related to HDL antioxidant capacity in type 2 diabetic patients [11,[27][28][29]. Interestingly, in type 2 diabetic patients, the antioxidant capacity of HDL can be decreased, whereas PON and PAF-AH activities are similar to those measured in controls [11], indicating that in type 2 diabetes mellitus other factors than the decrease of PON and PAF-AH activities are likely to impair HDL antioxidant activity.…”

Section: Discussionmentioning

confidence: 90%

Inability of HDL from type 2 diabetic patients to counteract the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation

et al. 2006

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Aims/hypothesis: In healthy normolipidaemic and normoglycaemic control subjects, HDL are able to reverse the inhibition of vasodilation that is induced by oxidised LDL. In type 2 diabetic patients, HDL are glycated and more triglyceride-rich than in control subjects. These alterations are likely to modify the capacity of HDL to reverse the inhibition of vasodilation induced by oxidised LDL. Subjects and methods: Using rabbit aorta rings, we compared the ability of HDL from 16 type 2 diabetic patients and 13 control subjects to suppress the inhibition of vasodilation that is induced by oxidised LDL. Results: Oxidised LDL inhibited endothelium-dependent vasodilation (maximal relaxation [Emax]=58.2± 14.6 vs 99.3±5.2% for incubation without any lipoprotein, p<0.0001). HDL from control subjects significantly reduced the inhibitory effect of oxidised LDL on vasodilatation (Emax=77.6±12.9 vs 59.5±7.7%, p<0.001), whereas HDL from type 2 diabetic patients had no effect (Emax=52.4±20.4 vs 57.2±18.7%, NS). HDL triglyceride content was significantly higher in type 2 diabetic patients than in control subjects (5.3±2.2 vs 3.1±1.4%, p<0.01) and was highly inversely correlated to Emax for oxidised LDL+HDL in type 2 diabetic patients (r=−0.71, p<0.005). Conclusions/interpretation: In type 2 diabetes mellitus, the ability of HDL to counteract the inhibition of endothelium-dependent vasorelaxation induced by oxidised LDL is impaired and is inversely correlated with HDL triglyceride content. These findings suggest that HDL are less atheroprotective in type 2 diabetic patients than in control subjects.

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Section: Discussionmentioning

confidence: 90%

Inability of HDL from type 2 diabetic patients to counteract the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation

et al. 2006

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“…Moreover, PON1 activity was also reported to be similar in diabetic patients, in subjects with impaired fasting glucose, and in normoglycemic controls [28,29], which suggested the loss of PON1 activity to occur later in the course of DM and hyperglycemia rather than in the stage of insulin resistance [8]. …”

Section: Discussionmentioning

confidence: 99%

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Karakaya

Özdemir²,

Mert³

et al. 2018

Obes Facts

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Aim: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. Methods: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am. Blood samples for glucose and insulin levels are taken 2 h after a standard meal. Blood tubes with EDTA are used for ANP levels. The microvascular complications of the patients are evaluated. Results: 32 of the patients had microvascular complications. Age, BMI, waist and hip circumferences, and ANP levels were significantly higher in the group with microvascular complications. There were no significant differences in waist-to-hip ratio, blood glucose, HbA1c, fasting insulin, postprandial insulin, fasting HOMA, postprandial HOMA as well as sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between ANP and obesity, retinopathy, neuropathy, nephropathy, diabetes time, HbA1c, or sex are evaluated separately, the only significant parameters related to ANP were obesity and retinopathy. Conclusion: In our study we have found that there was a significant relationship between ANP levels and microvascular complications of diabetes. Future studies are needed to show if ANP is the stimulus of microvascular complication development/progression or only an epiphenomenon.

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“…Oxidation of HDL in diabetic pa tients causes a change in the PON1 protein and an ensuing drop in PON1 activity (79). PON1 activity was shown to decrease in type 1 and type 2 diabetes patients in several studies, while some other studies reported that PON1 activity was not related to type 1 and type 2 diabetes (82)(83). Apart from that, it was noted in some studies that diabetes was correlated with PON1 polymorphism, although other studies failed to confirm this correlation (84-86).…”

Section: Clinical Significancementioning

confidence: 99%

The Past and Present of Paraoxonase Enzyme: Its Role in the Cardiovascular System and Some Diseases

Aydın¹,

Şahin²,

Aydın³

et al. 2012

Journal of Medical Biochemistry

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Summary: Although paraoxonase is synthesized in many tissues including the heart, colon, kidneys, lungs, small intestines and brain, its major locus of synthesis is the liver. PON1 is in close association with apolipoproteins and protects LDL against oxidation. It was reported that PON1 quantities dropped to 40 times lower than normal in cardiovascular diseases and diseases like diabetes, ulcerative colitis, Crohn's disease, chronic renal failure, SLE, Behcet's disease, cancer, hepatitis B, obesity, metabolic syndrome, Alzheimer's and dementia. It is speculated that the concerning decline in serum PON1 amount results from single nucleotide polymorphism in the coding (Q192R, L55M) and promoter (T-108C) sites of the PON1 gene. Additionally, circulating amounts of PON1 are affected by vitamins, antioxidants, fatty acids, dietary factors, drugs, age and lifestyle. This collection attempts to review and examine the past and present studies of paraoxonase and its relation with the cardiovascular system and some relevant diseases.Keywords: paraoxonase, polymorphism, cardiovascular system diseases Kratak sadr`aj: Iako se paraoksonaza sinteti{e u mnogim tkivima, uklju~uju}i srce, debelo crevo, bubrege, plu}a, tanko crevo i mozak, glavno mesto njene sinteze je jetra. PON1 je blisko povezana sa apolipoproteinima i {titi LDL od oksidacije. Koli~ine PON1 ~ak 40 puta ni`e od normalnog nivoa zabele`ene su u kardiovaskularnim bolestima i oboljenjima kao {to su dijabetes, ulcerozni kolitis, Kronova bolest, hroni~na bubre`na insuficijencija, sistemski eritemski lupus, Beh~etov sindrom, kancer, hepatitis B, gojaznost, metaboli~ki sindrom, Alchajmerova bolest i demencija. Spekuli{e se da pomenuti pad nivoa PON1 u serumu poti~e od polimorfizma pojedina~nih nukleotida na kodnim (Q192R, L55M) i promoterskim (T-108C) podru~jima gena PON1. Pored toga, na koli~inu PON1 u cirkulaciji uti~u vita mini, antioksidansi, masne kiseline, faktori ishra ne, le kovi, godine i na~in `ivota. Ovaj pregled predstavlja poku{aj da se izlo`e i razmotre pro{le i sada{nje studije o paraoksonazi i njenom odnosu sa kardiovaskularnim sistemom i nekim relevantnim bolestima.

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Lack of Association between Serum Paraoxonase 1 Activities and Increased Oxidized Low-Density Lipoprotein Levels in Impaired Glucose Tolerance and Newly Diagnosed Diabetes Mellitus

Cited by 39 publications

References 33 publications

Inability of HDL from type 2 diabetic patients to counteract the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation

Inability of HDL from type 2 diabetic patients to counteract the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

The Past and Present of Paraoxonase Enzyme: Its Role in the Cardiovascular System and Some Diseases

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